Advanced Search

Study Preview



Study Title and Description

Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on bone and calcium balance outcomes?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: the OFELY study.
Author G Albrand,F Munoz,E Sornay-Rendu,F DuBoeuf,PD Delmas,
Country
Year 2003
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Bone & Calcium Outcomes
Design Details
Question... Follow Up Answer Follow-up Answer
Refid 12584039
  • Comments Comments (
    0
    ) |
What outcome is being evaluated in this paper? Bone and Calcium
  • Comments Comments (
    0
    ) |
What is the objective of the study (as reported by the authors)? The objective of this study was to identify independent predictors of all osteoporosis-related fractures in healthy postmenopausal women.
  • Comments Comments (
    0
    ) |
Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Patient population: Cohort of 1039 women, 31– 89 years of age; all women are healthy ambulatory Caucasian volunteers, randomly selected from a health insurance company from a region around Lyon, France. 672 postmenopausal women (mean age 59.1 +/- 9.8 years) were followed for 5 years. Questionnaire: All women completed a written standardized baseline health questionnaire at the initial screening visit: social and professional conditions, current and past medical history, medication use, hormone replacement therapy (HRT), calcium and vitamin D supplementation, alcohol and caffeine consumption, tobacco use, calcium consumption, physical activity, reproductive characteristics, breast-feeding, age of menopause, numbers of years since menopause, and family history of fragility fracture (wrist fracture, humeral fracture, vertebral fracture, and hip fracture). Both coffee and tea consumption were recorded as number of cups by week. Physical examination: included height and weight, BMI, fat body mass and lean body mass, walking speed, balance, chair stand, physical activity questionnaire, as well as other variables. BMD and radiologic measurements BMD was measured by DXA on a Hologic QDR 2000 device; lunmbar spine, femoral neck, trochanter, total hip region. Women were followed once a year for a mean (+/-SD) of 5.3 +/- 1.1 years. Fracture incidence was assessed during the yearly visit. All peripheral fractures were confirmed by the radiologist and/or by the surgical report. Data analysis Fracture incidence is calculated by dividing the number of women with one or more fragility fracture by the number of women in the entire cohort; X2 and t tests were used to compare baseline characteristics between women with and without fragility fractures. A logistic regression model was used in the analysis of the relationship between potential risk factors and the risk of fragility fractures.
  • Comments Comments (
    0
    ) |
How many outcome-specific endpoints are evaluated? 1
  • Comments Comments (
    0
    ) |
What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Fracture
  • Comments Comments (
    0
    ) |
Clinical, physiological, other Clinical
  • Comments Comments (
    0
    ) |
What is the study design? Cohort
  • Comments Comments (
    0
    ) |
Randomized or Non-Randomized?
  • Comments Comments (
    0
    ) |
What were the diagnostics or methods used to measure the outcome? Objective
  • Comments Comments (
    0
    ) |
Optional: Name of Method or short description Fracture self-reported, but validated via radiologist or surgical records
  • Comments Comments (
    0
    ) |
Caffeine (general)
  • Comments Comments (
    0
    ) |
Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? coffee, tea
  • Comments Comments (
    0
    ) |
Measured or self reported? Self-report
  • Comments Comments (
    0
    ) |
Children, adolescents, adults, or pregnant included? Adults
  • Comments Comments (
    0
    ) |
What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Coffee and tea consumption (cups/week) in women with and without fracture
  • Comments Comments (
    0
    ) |
What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) None (in analyses involving coffee/tea/caffeine)
  • Comments Comments (
    0
    ) |
What were the sources of funding? Not reported by authors.
  • Comments Comments (
    0
    ) |
What conflicts of interest were reported? Not reported by authors.
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.