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Study Title and Description

Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on bone and calcium balance outcomes?
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Primary Publication Information
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TitleData
Title Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: the Osteoporotic Fractures in Men Study.
Author KE Barbour,JM Zmuda,ES Strotmeyer,MJ Horwitz,R Boudreau,RW Evans,KE Ensrud,MA Petit,CL Gordon,JA Cauley, ,
Country
Year 2010
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Bone & Calcium Outcomes
Design Details
Question... Follow Up Answer Follow-up Answer
Refid 20200975
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What outcome is being evaluated in this paper? Bone and Calcium
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What is the objective of the study (as reported by the authors)? Identify correlates of trabecular and cortical vBMD using peripheral QCT (pQCT) and examine whether they differ
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Study Population: 5995 men aged 65 years or older from six US clinical sites (Osteoporotic Fractures in Men Study); pQCT measurements obtained at Minneapolis, MN and Monongahela Valley, PA. in 1172 individuals aged 69 to 97 years. pQCT Measurements: - pQCT examinations were performed on the Sratec XCT scanner series -Trabecular and cortical vBMD (volumetric BMD) of radius and tibia - QA phantom scan used to monitor stability of pQCT scanner; cross-calibration check performed between the centers - Proximal radius and tibia shaft scans were analyzed using identical parameters for contour finding and separation of total and cortical bone to determine the vBMD of the cortical-rich bone compartment - Coefficients of variation (CVs) were determined for pQCT scans by replicating measurements on 15 subjects Other measurements: - Self-administered and interviewer-administered questionnaires were used by trained clinical staff to obtain demographic, medical, and lifestyle information from the participants. Lifestyle factors included self-report of smoking (current, past, and never), alcohol intake (drinks/week), caffeine intake (mg/day), and time spent walking (hours/day). - Information on anthropometric measures, neuromuscular function, and medication use also was obtained at the clinic. Statistical analysis - Analysis of variance (ANOVA) was used to compare the unadjusted skeletal site-specific vBMD across age groups with a test of trend and a Bonferroni adjustment for pairwise comparisons. - Linear regression analyses for age- and age- and weight-adjusted models were used to examine the association of each correlate with cortical and trabecular vBMD at the radius and tibia. The associations were expressed as a 1 unit increase for categorical variables and 1 standard deviation (SD) increase for continuous variables. - Variables with a p value of less than .10 from the age- and weightadjusted models were entered into the multivariable models. For the multivariable models, backward elimination was used at each skeletal site with age forced in the models.Multicollinearity was assessed using the variance inflation factor (VIF).
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How many outcome-specific endpoints are evaluated? 1
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Volumetric bone mineral density (vBMD) - measured via trabecular and cortical measurements of radius and tibia
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Clinical, physiological, other Clinical
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What is the study design? Cross-sectional
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Randomized or Non-Randomized?
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description pQCT examinations were performed on the Sratec XCT scanner series (2000 or 3000, Stratec, Inc., Pforzheim, Germany). Trabecular vBMD of the radius and tibia was measured by obtaining an ultradistal slice at 4% of the length of the ulna proximal to the radial endplate and at 4% of the tibia length proximal to the tibial endplate, respectively. Cortical vBMD of the radius and tibia was measured by obtaining a distal slice at 33% of the length of the ulna proximal to the radial endplate and at 33% of the tibia length proximal to the tibial endplate, respectively.
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other?
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Measured or self reported? Self-report
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Caffeine evaluated as continuous variable (mg/day)
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) Confounder: Age, height, weight, race/ethnicity, education, alcohol intake, calcium and vitamin D intake, history of a nontrauma fracture after age 50, diabetes and fasting glucose level, gastrectomy, testosterone injection use, hypertension (and other medical history aspects), gait speed, smoking.
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What were the sources of funding? The Osteoporotic Fractures in Men (MrOS) Study is supported by NIH funding. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA), the National Center for Research Resources (NCRR), and NIH Roadmap for Medical Research under the following Grant Numbers: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01 AG027810, and UL1 RR024140. American Diabetes Association (1-04-JF-46, Strotmeyer ES).
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What conflicts of interest were reported? All the authors state that they have no conflicts of interest.
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Results & Comparisons

No Results found.