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Study Title and Description

The influence of a taurine containing drink on cardiac parameters before and after exercise measured by echocardiography.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title The influence of a taurine containing drink on cardiac parameters before and after exercise measured by echocardiography.
Author M Baum,M Weiss,
Country
Year 2001
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? The aim of this present study was to determine whether taurine administration, as a constituent of Red Bull, would have an effect upon functional cardiac parameters, especially ventricular function.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Subjects and Methods Thirteen trained endurance athletes (7 triathlons, 4 cyclists, 2 runners who trained more than 11 hours per week of endurance exercise for 6 years) participated in the study. All subjects were volunteers, healthy and drug free. The study was conducted during a twelve-week period when the subjects training schedules were held at a constant level. In the days prior to the exercise test no training, alcohol or stimulants were allowed. Three hours before the exercise the subjects received a standardized breakfast without caffeine. Forty minutes before the test exercise one of the three drinks under investigation was consumed (500 ml): D1 ("Red Bull" without taurine, glucuronolacton, or caffeine, but with glucose and saccarose; "Placebo"), D2 ("Red Bull" without taurine or glucuronolacton, but with caffeine (160 mg) glucose, and saccarose; "Control ") or D3 ("Red Bull" original drink containing taurine, glucuronolacton, caffeine (160 mg), glucose, and saccarose; "Verum "), was consumed. Echocardiographic examinations were performed before the ingestion of the test drink, immediately prior to the exercise and in the regeneration period, when the heart rate had declined to about 70 beats per minute. The exercise intensity was determined about one week before the scheduled research, with the goal of reaching the point of exhaustion by the end of the exercise period. Echocardiographic Methods All subjects were examined by M-Mode, 2-dimensional and pulsed wave Doppler echocardiography on a Hitachi (model EUB 525) ultrasound machine. M-mode measures were obtained according to the American Society of Echocardiography guidelines, using "leading edge to leading edge" method (Quinones et al., 1978). Systolic and diastolic left ventricular volumes were calculated from the Teichholz formula (Teichholz et al., 1976), also the stroke volume. Fractional shortening (FS) was calculated as LVEDD – LVESD/ LVEDD (LVEDD left ventricular end-diastolic diameter, LVESD left ventricular end-systolic diameter). Doppler examination of the diastolic left ventricular inflow was performed from an apical 4-chamber view, the sample volume was placed between the mitral leaflet tips. The ultrasound beam was lined up parallel to left ventricular inflow to minimize the angle between beam and inflow. The angle was lower than 25 degrees in all examinations. Left ventricular inflow during three subsequent heart beats was measured. Peak early diastolic inflow (E-wave) and peak late diastolic inflow (A-wave) were calculated from the results (mean of three measurements). Statistics The significance of the data was validated by the Friedmann (nonparametric analysis of variance) and Wilcoxon test (post-hoc test), using a significance level of p </= 0.05 as significant. Results are given as mean and standard deviation.
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How many outcome-specific endpoints are evaluated? 4
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure
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List additional health endpoints (separately). 2 Heart rate
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List additional health endpoints (separately).3 Ventricular function (fractional shortening [FS], left ventricular end diastolic diameter [LVEDD], left ventricular end systolic diameter [LVESD], early peak diastolic inflow velocity [VE], late peak diastolic inflow velocity [VA])
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List additional health endpoints (separately).4 Stroke volume
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description Endpoints measured by instruments
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Energy drinks
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Each person received the same treatment and served as their only controls. Treatments included placebo (no caffeine or taurine), "control" (caffeine), and "verum" (caffeine and taurine)
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) None
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What conflicts of interest were reported? No information provided
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Refid 11310932
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What were the sources of funding? No information provided
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Results & Comparisons

No Results found.