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Study Title and Description

Maximum cognitive performance and physiological time trend measurements after caffeine intake.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title Maximum cognitive performance and physiological time trend measurements after caffeine intake.
Author C Kourtidou-Papadeli,C Papadelis,AL Louizos,O Guiba-Tziampiri,
Country
Year 2002
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? The effect of caffeine on the central nervous system and cardiorespiratory system was tested under resting conditions and while undertaking a multitask performance test.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Sixteen young healthy volunteers with an average age of metabolizes caffeine faster. Given the fact that the subjects 21 years, male and female participated in this study. The subjects were divided into three groups: Group A consisted of six subjects: non-smokers and non-coffee drinkers, Group B consisted of five subjects: smokers and coffee drinkers and Group C consisted of five subjects: non-smokers and coffee drinkers. We classified as coffee drinkers those subjects that were ingesting one to two cups of coffee per day. Heavy coffee drinkers were two subjects of each group (Groups B and C) who were ingesting more than two cups of coffee per day and were also consuming other beverages, which contain caffeine. The main study was performed in two different days where different coffee doses where used with session 1 corresponding to 90 mg of caffeine intake and session 2 to 250 mg. Caffeine was administered by 110 ml of ‘Nescafe’ beverage containing 90 mg of caffeine, the equivalent of one cup of coffee and 300 ml for the dose of 250 mg of caffeine, the equivalent of three cups of coffee. The subjects abstained from all food or drink containing caffeine for 1 week before the study begun. On the first day of the study, blood pressure and heart rate were measured at rest and monitored continuously throughout the study. The multi- task performance test (MATB tracking task) which lasted for 16 min each time was repeated at rest (Test-0) as well as 30 min (Tes-1), 90 min (Test-2) and 150 min (Test3) after 90 mg of caffeine intake. A repetition of the experiment was carried out 3 days after the first day and students that abstained from coffee had a higher dose of caffeine, 250 mg instead of 90 mg. To compare physiological data before and after caffeine intake in different time periods, paired t -test was used as well as analysis of variance and correlation to compare the physiological parameters with performance and caffeine dose.
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How many outcome-specific endpoints are evaluated? 2
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure
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List additional health endpoints (separately). 2 Heart rate
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description No method provided; however, because SBP data provided, it was assumed that some instrument was used (vs. perceived change)
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Coffee
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Each subject served as their own control
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) Subjects divided into 3 groups: non-smokers and non-coffee drinkers; smokers and coffee drinkers; non-smokers and coffee drinkers, and results compared across groups
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What conflicts of interest were reported? No information provided
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Refid 11919004
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What were the sources of funding? No information provided
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Results & Comparisons

No Results found.