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Study Title and Description

Effects of caffeine on microcirculation of the human ocular fundus.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title Effects of caffeine on microcirculation of the human ocular fundus.
Author T Okuno,T Sugiyama,M Tominaga,S Kojima,T Ikeda,
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Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? In the present study, we used the laser speckle method to evaluate the effects of caffeine ingestion on human ocular microcirculation.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) The subjects in this study were 10 healthy volunteers (10 eyes) without any ophthalmologic disorders (other than simple myopia), and comprised 5 men and 5 women ranging in age from 25 to 44 years. Caffeine ingestion, food and drink of any kind, and exercise were prohibited for 6 hours, 2 hours, and 30 minutes before testing, respectively. The study was conducted in a double-blind manner. All subjects underwent the same experimental procedure. During the study period, each subject was examined at 1-week intervals and given a capsule containing either 100 mg caffeine or 100 mg lactose (as the control) before the testing. To minimize any diurnal variation effects, testing was conducted at the same time each day. At each weekly examination, blood pressure [NOTE: and presumably heart rate] was measured before and after the oral administration of caffeine or placebo at 15-minute intervals afterward for up to 2 hours. Brachial arterial blood pressure and pulse rate were measured using an automated sphygmomanometer (JENTOW-7700[CS]; Nippon Colin, Komaki). Mean blood pressure (BPm) was calculated from systolic blood pressure (BPs) and diastolic blood pressure (BPd), according to the following equation: BPm = BPd + 1/3(BPs-PBd).
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How many outcome-specific endpoints are evaluated? 2
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure (SBP and DBP measured, but only calculated mean BP reported)
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List additional health endpoints (separately). 2 Heart rate
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description Brachial arterial blood pressure and pulse rate were measured using an automated sphygmomanometer (JENTOW-7700[CS]; Nippon Colin, Komaki).
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other?
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Each subject served as their own control (placebo)
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) None
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What conflicts of interest were reported? No information provided
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Refid 12062222
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What were the sources of funding? No information provided
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