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Study Title and Description

The moderating effect of anxiety sensitivity on caffeine-induced hypoalgesia in healthy women.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title The moderating effect of anxiety sensitivity on caffeine-induced hypoalgesia in healthy women.
Author E Keogh,N Chaloner,
Country
Year 2002
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? The primary aim of this study was to determine whether caffeine has a differential effect on the pain responses of those high, medium and low in anxiety sensitivity. Our secondary aim was to determine whether anxiety sensitivity groups differ in their physiological (blood pressure) and psychological (mood) responses to caffeine.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) A total of 36 female participants were recruited (n=12 per anxiety group [low, medium, high]), with ages ranging between 18 and 55 years (mean 24.83; SD 8.71). No significant group differences were found in age or body mass. Participants were run in a placebo-controlled repeated measures experiment. In the caffeine condition, participants consumed a cup of decaffeinated coffee, which contained 250 mg caffeine. In the placebo condition, decaffeinated coffee was administered. Participants were initially tested in either the placebo or the caffeine condition (order was counterbalanced between participants), and then again around 1 week later, in the alternative condition. On each day of testing arousal (objective and subjective) was measured once prior to the ingestion of caffeine/placebo drink and again 40 min later. At each testing phase, three readings of blood pressure and pulse were taken from the brachial artery on the inner side of the biceps and an average calculated. The arousal mood data was tested in a 3 (Anxiety sensitivity: low versus medium versus high) x 2 (caffeine condition: caffeine versus placebo) x 2 (time of testing: before versus after ingestion of caffeine/placebo) mixed groups design. Anxiety sensitivity served as the between-groups factor, whereas caffeine condition and time of testing served as within-groups factors.
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How many outcome-specific endpoints are evaluated? 2
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure (SBP and DBP)
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List additional health endpoints (separately). 2 Heart rate
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? RCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description Three readings of blood pressure and pulse were taken from the brachial artery on the inner side of the biceps and an average calculated [NOTE: Study references earlier paper by lead author for more information on methods. In this paper, it was noted that blood pressure and heart rate were taken using an automated sphygmomanometer (Mars oscillometric digital blood pressure monitor, model MS-700).
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Coffee
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Subjects served as their own controls (placebo)
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) Anxiety level based on Anxiety Sensitivity Index
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What conflicts of interest were reported? No information provided
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Refid 12457274
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What were the sources of funding? No information provided
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Results & Comparisons

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