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Study Title and Description

Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations.
Author C Papadelis,C Kourtidou-Papadeli,E Vlachogiannis,P Skepastianos,P Bamidis,N Maglaveras,K Pappas,
Country
Year 2003
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? The goal of this study was to clarify if the effects of caffeine in performance may or may not be independent of those of catecholamines it releases.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Sixteen healthy volunteers (10 men with a mean body weight of 80 +/- 5 kg and 6 women with a mean body weight of 65 +/- 5 kg) of mean age 22 years old (SD: 3, range: 18–26) participated in this study, trained on an electronic multitask program for at least 3 weeks until they established their baseline. They were given a number, so that the investigator did not know anything about the subjects’ habits. They also responded to a questionnaire regarding their smoking and caffeine drinking habits, as well as their health status. All subjects abstained from caffeine drinks for at least 1 week before the study. During the study they performed the same tasks under the influence of a single and a triple dose of caffeine. Caffeine was weighted and the percentage of caffeine diluted in the cup was calculated. To select a dose of caffeine we used a predetermined quantity of instant coffee and diluted to 100 ml of water, which the subjects had to consume in 10 min. After caffeine was diluted, samples were sent to the General Chemistry Department of the Greek government and we received the exact amount of caffeine in each one of them. Subsequently, the caffeine concentration (1.4% caffeine or 62 mg caffeine/100 ml coffee) was analyzed and we established that for an 80 kg individual 1 coffee cup of 150 ml would be 1.5 mg/kg/day and 3 coffee cups (total 400–500 ml) would be 4.5 mg/kg/day. The coffee was always prepared in the same way and the volume consumed was based on the weight of the subject to provide the required caffeine dose. The subjects were divided into three groups according to their smoking and coffee drinking habits. Group A consisted of non-smokers and non-coffee drinkers; group B of smokers and coffee drinkers; and group C of non-smokers and coffee drinkers. The amount of urinary catecholamines, excreted after administration of 1 cup of coffee, 3 cups of coffee, after mental workload (stress) with no caffeine interference, and at rest was determined, from the concentration in the sample, multiplied by the total urine volume. We used the method of high performance chromatography with electrochemical detection (Hjemdahl et al., 1989; Lundberg, Holmberg, & Frankenhaeuser, 1988) to determine urine catecholamines. [NOTE: No information is provided regarding method for blood pressure measurements.] [NOTE: No information on statistical methods provided.]
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How many outcome-specific endpoints are evaluated? 2
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure
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List additional health endpoints (separately). 2 Urinary catecholamines (adrenaline and noradrenaline)
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description We used the method of high performance chromatography with electrochemical detection to determine urine catecholamines. [NOTE: No information is provided regarding method for blood pressure measurements.]
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Coffee
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Subjects served as their own controls
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) Coffee consumption or smoking (or lack thereof)
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What conflicts of interest were reported? No information provided
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Refid 12633594
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What were the sources of funding? No information provided (however, the Greek government analyzed the caffeine samples)
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Results & Comparisons

No Results found.