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Study Title and Description

Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans.
Author GS Yukawa,M Mune,H Otani,Y Tone,XM Liang,H Iwahashi,W Sakamoto,
Country
Year 2004
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? The aim of the present study was to investigate the in vivo effects of coffee on the oxidative modification of LDL and lipid metabolism.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Coffee was consumed by eleven healthy male students (21 and 31 years of age) from Wakayama Medical University. They ate usual Japanese diets and drank only mineral water as a beverage throughout this study. On days 1-7 before the study (Baseline; B), the subjects drank only mineral water as a beverage. Starting on day 7 (After one week; A), subjects drank 150 ml coffee three times per day for one week. This was followed by a one-week (W) "washout" period during which only mineral water was consumed. Fasting peripheral venous blood samples (at least 12 h after coffee ingestion) were taken at the end of each one-week period. Coffee Preparation Coffee was made by dissolving 8 g of Arabica coffee (Ajinomoto General Foods, Inc., Japan) in one mug of boiling water immediately before drinking. Standard mugs (volume of beverage ingested, 150 ml) were used throughout the study. Biochemical Analysis Blood and urine chemistry were carried out by a standard laboratory method using a 7170 autoanalyzer (Hitachi Co., Japan). Statistical Analysis For statistical calculation, Student’s t-test was used. Data are given as mean and standard deviations (mean ± SD). A significant difference was accepted when p < 0.05.
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How many outcome-specific endpoints are evaluated? 1
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Serum cholesterol (TC, LDL, HDL)
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List additional health endpoints (separately). 2
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description Blood and urine chemistry were carried out by a standard laboratory method using a 7170 autoanalyzer (Hitachi Co., Japan).
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Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Coffee
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Subjects served as their own controls
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) None
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What conflicts of interest were reported? No information provided
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Refid 14972021
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What were the sources of funding? No information provided
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Results & Comparisons

No Results found.