Advanced Search

Study Preview



Study Title and Description

A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title A combination of caffeine and taurine has no effect on short term memory but induces changes in heart rate and mean arterial blood pressure.
Author A Bichler,A Swenson,MA Harris,
Country
Year 2006
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
  • Comments Comments (
    0
    ) |
What is the objective of the study (as reported by the authors)? We investigated the combined effects of Red Bull’s two active ingredients, caffeine and taurine, on short term memory.
  • Comments Comments (
    0
    ) |
Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Subjects Fourteen undergraduate student volunteers (8 female and 6 male), aged 18 to 23 (mean age 20.5 +/- 1.5 SD), participated in the study. The subjects reported no histories of heart conditions or allergies to caffeine or taurine. All subjects were moderate (2–4 caffeinated beverages=day) or infrequent (0–1 caffeinated beverage=day) caffeine consumers. They were instructed to abstain from caffeine and taurine consumption for 24 h prior to testing, and on the day of testing all subjects reported in writing that they had done so. Procedure overview Each subject came in for testing on two occasions that were separated by a minimum of 24 and a maximum of 240 h. During one trial they received the active treatment, 100mg caffeine and 1000mg taurine, both in pill form. These are nearly equivalent to the 80mg caffeine and 1000mg taurine amounts found in a standard 250ml can of Red Bull energy drink. During the other trial subjects received two placebo sugar pills. The treatments were administered in a double-blind fashion and the order of treatment was randomized. Subjects completed a short term memory exam 45 min after ingesting a treatment. Subject heart rate and blood pressure were measured on three occasions throughout the trials using an Omron automatic digital blood pressure monitor (model HEM-747IC). Mean arterial blood pressure (MABP) was calculated from systolic and diastolic values, where MABP = diastolic BP x (0.333 x (systolic-diastolic BP)). Baseline Measurements Each subject was tested individually in a small, quiet room. When subjects arrived in the testing room, they were instructed to sit down and read or study quietly for 30min after which resting heart rate and blood pressure were measured (HR1 and MABP1, respectively; see Fig. 1). At this point, the subjects received the test drugs (either the caffeine=taurine treatment or placebo) which were put into pharmaceutical containers that did not allow the proctors or the subjects to know which drug was contained inside. Data Analysis Data were analyzed using SPSS version 12.0 for Windows. The Wilcoxon test was used to evaluate changes in heart rate and mean arterial blood pressure during the course of the test for both placebo and treatment trials. Differences were considered significant if p-value <0.05.
  • Comments Comments (
    0
    ) |
How many outcome-specific endpoints are evaluated? 2
  • Comments Comments (
    0
    ) |
What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure (MAP)
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately). 2 Heart rate
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).3
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).4
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).5
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).6
  • Comments Comments (
    0
    ) |
Clinical, physiological, other Physiological
  • Comments Comments (
    0
    ) |
What is the study design? Controlled Trial
  • Comments Comments (
    0
    ) |
Randomized or Non-Randomized? RCT
  • Comments Comments (
    0
    ) |
What were the diagnostics or methods used to measure the outcome? Objective
  • Comments Comments (
    0
    ) |
Optional: Name of Method or short description Subject heart rate and blood pressure were measured using an Omron automatic digital blood pressure monitor (model HEM-747IC). Mean arterial blood pressure (MABP) was calculated from systolic and diastolic values, where MABP = diastolic BP x (0.333 x (systolic-diastolic BP)).
  • Comments Comments (
    0
    ) |
Caffeine (general) Caffeine (general)
  • Comments Comments (
    0
    ) |
Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other?
  • Comments Comments (
    0
    ) |
Measured or self reported? Measured
  • Comments Comments (
    0
    ) |
Children, adolescents, adults, or pregnant included? Adults
  • Comments Comments (
    0
    ) |
What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Subjects served as their own controls (baseline
  • Comments Comments (
    0
    ) |
What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) None
  • Comments Comments (
    0
    ) |
What conflicts of interest were reported? No information provided
  • Comments Comments (
    0
    ) |
Refid 16699827
  • Comments Comments (
    0
    ) |
What were the sources of funding? No information provided
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.