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Study Title and Description

Effect of caffeine on lower esophageal sphincter pressure in Thai healthy volunteers.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title Effect of caffeine on lower esophageal sphincter pressure in Thai healthy volunteers.
Author S Lohsiriwat,N Puengna,S Leelakusolvong,
Country
Year 2006
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? This study aimed to examine the effect of caffeine upon the lower esophageal sphincter (LES) and esophageal function in healthy Thai subjects who normally had no gastrointestinal symptoms.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) This cross-sectional experimental study was performed during January to May 2002. 2002). Twelve healthy volunteers of both genders (6 male and 6 female) were studied at the GI motility laboratory, Division of Gastroenterology, Department of Medicine, Siriraj Hospital, Bangkok, Thailand. They were 19–31 years old, regular coffee consumers, more than three cups a week, and had never experienced symptoms such as tachycardia, palpitation, nausea or skin rash after coffee-drinking. The subjects used no medication at all at least 1 week before the experiment. A heavy smoker (more than 20 cigarettes/day) or a person having any diseases such as heart disease, diabetes mellitus, hypertension, cancer and gastrointestinal disorders was excluded. The study was performed in a single-blind manner. Each subject fasted for at least 4 h and refrained from smoking or any alcoholic drink overnight. Subjects consumed 100 mL water (control drink) and LES pressure was continuously recorded for 30 min. Subjects then consumed another 100 mL drink containing 3.5 mg of caffeine/kg. The LES pressure measurement was conducted for another 30 min. Before and at 10-minute intervals after ingestion of caffeine or the control drink, the arterial pulse rate was recorded. Systolic and diastolic blood pressures were also manually measured by the same registered nurse using the same sphygmomanometer throughout the experiment. Data were calculated by computer, using the SPSS statistical program. All basic parameters such as LES pressure, amplitude, duration and velocity were presented as mean plus and minus one standard deviation. Kolmogorov-Smirnov test was used to test the data distribution. Student’s paired t-test was used to compare the data in the group with normal distribution or Wilcoxon’s signed-rank test with non-normal distribution. A P-value < 0.05 was considered to be statistically significant.
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How many outcome-specific endpoints are evaluated? 2
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure (SBP and DPB)
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List additional health endpoints (separately). 2 Heart rate
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description Arterial pulse rate and systolic and diastolic blood pressures were manually measured by the same registered nurse using the same sphygmomanometer throughout the experiment.
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other?
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Subjects served as their own controls (baseline and placebo)
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) None
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What conflicts of interest were reported? No information provided
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Refid 16722996
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What were the sources of funding? No information provided
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Results & Comparisons

No Results found.