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Study Title and Description

The effect of four coffee types on normotensive rats and normal/hypertensive human volunteers.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title The effect of four coffee types on normotensive rats and normal/hypertensive human volunteers.
Author AS Awaad,GA Soliman,MR Al-Outhman,IF Al-Shdoukhi,RS Al-Nafisah,J Al-Shamery,R Al-Samkhan,M Baqer,NA Al-Jaber,
Country
Year 2011
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? The purpose of this study was to determine the effect of the four coffee types on blood pressure (BP).
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) Subjects. Four hundred independent-living nonsmoking men (n = 200) and women (n = 200) in Riyadh (range 20–39 years and body weight 72–105 kg) were recruited to take part in a clinical trial of the effects of coffee drinking on blood pressure. All were non-habitual caffeine consumers who did not routinely drink coffee every day. They were either normotensive (SBP of 118– 124 mmHg and/or DBP of 77–86 mmHg) or mildly hypertensive (SBP of 140–159 mmHg) and/or DBP of 90–99 mmHg). Written informed consent was obtained from all participants after they received a full written explanation of the content and the aim of the study. Study protocol. The ratios of normotensives to mild hypertensive males and females in all groups were intended to be 1:1. The subjects were asked to abstain from caffeine-containing foods and beverages for at least 2 weeks before start of the study. During this period, the subjects were given the following instructions: continue usual dietary habits without drinking and eating too much: and no change in exercise habits. In addition, subjects were prohibited from ingesting blood pressure-influencing drugs. On the day before examination, they were instructed to finish dinner by 9:00 p.m. and not to eat or drink anything but water until the end of examination. On the day of examination, BP and HR were measured as baseline with a strain-gauge plethysmograph after the subject arrived at the clinic and sat quietly for at least 10 min. Each volunteer received a single cup of one of the test beverages (250 mL), between 09:00 and 10:00 a.m. All beverages were made with just boiled water and consumed within 10 min. Artificial sweetener (Equal® Tablets) was used to sweeten the test drinks. BP (SBP and DBP) and HR of each subject were measured at 0.5, 1.0, 1.5 and 2.0 h post-administration. All measurements were performed for subjects in the supine position in a temperature-controlled (22°C to 25°C), quiet, dark laboratory.
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How many outcome-specific endpoints are evaluated? 2
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Blood pressure
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List additional health endpoints (separately). 2 Heart rate
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description On the day of examination, BP and HR were measured as baseline with a strain-gauge plethysmograph after the subject arrived at the clinic and sat quietly for at least 10 min.
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Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Coffee
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Baseline heart rate or blood pressure was compare to measurements taken at 0.5, 1, 1.5 and 2 hours post-exposurse to coffee.
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) The results are expressed as mean +/- SE. Values of p < 0.05 and p < 0.05 were considered to indicate statistical significance. The effects of interventions on BP and HR were analyzed with the paired Student’s t -test.
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What conflicts of interest were reported? Authors had no conflicts of interest.
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Refid 21086544
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What were the sources of funding? Not discussed.
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Results & Comparisons

No Results found.