Advanced Search

Study Preview



Study Title and Description

Acute effects of coffee on QT interval in healthy subjects.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Acute effects of coffee on QT interval in healthy subjects.
Author S Buscemi,A Mattina,MR Tranchina,S Verga,
Country
Year 2011
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
  • Comments Comments (
    0
    ) |
What is the objective of the study (as reported by the authors)? Since the cardiovascular effects of coffee are still a debated matter, this study aimed at investigating with a randomized, double-blind crossover design, if the QT interval of adult healthy subjects (19 males and 21 females) changes in the hour following CC or DC ingestion.
  • Comments Comments (
    0
    ) |
Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) The study design has been previously described elsewhere [1]. The study was approved by the ethics committee of the University Hospital Policlinico P. Giaccone of Palermo, Italy, and registered as an International Standardized Randomized Controlled Trial (ISRCTN85096812). Briefly, 40 volunteers (19 males and 21 females) aged 21-49 years and with body mass index (BMI, (body weight (kg)/height (m)2 ) between 17.3-28.0 kg/m2 were included in the study. Exclusion criteria were any dyslipidemia, hypertension, diabetes, cardiovascular or systemic disease, any medication treatment, smoking of any tobacco products, pregnancy or lactation in the past 6 months, habitual daily consumption of greater than two cups of coffee or weekly ingestion of more than one commercial caffeinated beverage and abstaining from chocolate or other flavonoid-containing beverages up to the preceding day. The study followed a randomized, crossover, double blind design with each subject receiving two different study treatments, in random order, and repeated on separate days at 5- to 7-day intervals. The preparation of either CC and DC has already been described elsewhere [1]. Each packet of CC or DC contained a mixture of 65% Robusta (variety Canephora) and Arabica (A. Morettino s.p.a.; Palermo, Italy). The average caffeine content in 25 ml of CC and DC measured by chromatography-spectrophotometry (Chemical Laboratory, Camera di Commercio Industria Artigianato e Agricoltura, Trieste, Italy) was 130 mg and 5 mg, respectively. No addition of sugar or milk was permitted. Subjects had continuous electrocardiogram (ECG) and blood pressure (10 min intervals) recorded for the duration of each test. Three computed standard 12-lead ECG (Mortara Rangoni, Bologna, Italy) were performed at three minute intervals before and one hour after coffee ingestion; both the QT and QTc (Bazzett’ s formula) intervals of each ECG were automatically measured using a dedicated software.
  • Comments Comments (
    0
    ) |
How many outcome-specific endpoints are evaluated? 3
  • Comments Comments (
    0
    ) |
What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Heart rate
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately). 2 Blood pressure
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).3 QT internal and heart rate corrected QT internal (QTc)
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).4
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).5
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).6
  • Comments Comments (
    0
    ) |
Clinical, physiological, other Physiological
  • Comments Comments (
    0
    ) |
What is the study design? Controlled Trial
  • Comments Comments (
    0
    ) |
Randomized or Non-Randomized? RCT
  • Comments Comments (
    0
    ) |
What were the diagnostics or methods used to measure the outcome? Objective
  • Comments Comments (
    0
    ) |
Optional: Name of Method or short description Three computed standard 12-lead ECG (Mortara Rangoni, Bologna, Italy) were performed at three minute intervals before and one hour after coffee ingestion; both the QT and QTc (Bazzett’ s formula) intervals of each ECG were automatically measured using a dedicated software.
  • Comments Comments (
    0
    ) |
Caffeine (general)
  • Comments Comments (
    0
    ) |
Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other? Coffee
  • Comments Comments (
    0
    ) |
Measured or self reported? Measured
  • Comments Comments (
    0
    ) |
Children, adolescents, adults, or pregnant included?
  • Comments Comments (
    0
    ) |
What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Decaffeinated coffee and also basal measurements were taken in both groups.
  • Comments Comments (
    0
    ) |
What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) All data are presented as means ± standard error of the means. Basal pairwise comparisons between the two treatments (CC vs DC) were tested for statistical significance using the paired Student’ s t-test. An overall 3 Å~ 2 ANOVA (analysis of variance) for repeated measures was performed to evaluate the composite effect of the two different (CC and DC) ingested coffees over time (three periods: baseline, and 30 and 60 min) on the parameters of interest. ANOVA for repeated measures was also carried out separately to detect significant changes in variables over time within the two sessions; Bonferroni’ s t-test was performed for individual differences between two time points (paired) when appropriate. A two-tailed P < 0.05 was considered significant.
  • Comments Comments (
    0
    ) |
What conflicts of interest were reported? The authors declared they had0 no competing interests.
  • Comments Comments (
    0
    ) |
Refid 21288364
  • Comments Comments (
    0
    ) |
What were the sources of funding? No funding/grants mentioned.
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.