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Study Title and Description

Differential effects of intranasal insulin and caffeine on cerebral blood flow.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
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Primary Publication Information
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TitleData
Title Differential effects of intranasal insulin and caffeine on cerebral blood flow.
Author Y Grichisch,M Çavuşoğlu,H Preissl,K Uludağ,M Hallschmid,N Birbaumer,HU Häring,A Fritsche,R Veit,
Country
Year 2012
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
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What is the objective of the study (as reported by the authors)? To test whether insulin has a specific effect on CBF and BOLD response under euglycaemic conditions, we used an intranasal insulin application and simultaneously measured the corresponding BOLD and CBF responses by using arterial spin-labeling MRI. Furthermore, we compared the insulin effect with caffeine.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) MR images were acquired on a 3T Siemens MAGNETOM TIM-Trio (Erlangen, Germany) scanner using a 12- channel trans-receiver head coil. To improve the co-registration between sessions, laser alignment was used to landmark the head position.
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How many outcome-specific endpoints are evaluated? 1
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Cerebral blood flow
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List additional health endpoints (separately). 2
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List additional health endpoints (separately).3
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List additional health endpoints (separately).4
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List additional health endpoints (separately).5
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List additional health endpoints (separately).6
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Clinical, physiological, other Physiological
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What is the study design? Controlled Trial
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Randomized or Non-Randomized? NCT
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What were the diagnostics or methods used to measure the outcome? Objective
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Optional: Name of Method or short description MR images were acquired on a 3T Siemens MAGNETOM TIM-Trio (Erlangen, Germany) scanner using a 12- channel trans-receiver head coil. To improve the co-registration between sessions, laser alignment was used to landmark the head position.
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Caffeine (general) Caffeine (general)
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Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other?
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Measured or self reported? Measured
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Children, adolescents, adults, or pregnant included? Adults
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Baseline pre-exposure measures.
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) The subjects had no history of psychiatric or neurologic problems. A two-way repeated-measure ANOVA was used to evaluate the effects of two within-subjects’ factors including stimulation (resting or stimulation period) and treatment (predose compared to postdose) on the CBF and BOLD response separately for the insulin and the caffeine day in the predefined ROIs. Regression coefficients were computed using an ordinary least square fit between the CBF-values in the same voxels before (predose measurement) and after treatment (postdose measurement) separately for condition and day. In addition, the r2 values estimating the goodness of fit of the regression lines to the pre- and postdose conditions (separately for resting and stimulation periods) were computed.
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What conflicts of interest were reported? Not discussed.
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Refid 21391271
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What were the sources of funding? Contract grant sponsor: ‘‘Kompetenznetz Adipositas’’ (Competence Network for Adiposity); Contract grant numbers: FKZ: 01GI0837, 01GI0849; Contract grant sponsors: German Center for Diabetes Research (DZD e.V.), German Federal Ministry of Education and Research (BMBF); Contract grant sponsor: Deutsche Forschungsgemeinschaft; Contract grant number: BI 195/62.
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Results & Comparisons

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