Advanced Search

Study Preview



Study Title and Description

Caffeine ingestion and intense resistance training minimize postexercise hypotension in normotensive and prehypertensive men.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on cardiovascular outcomes?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Caffeine ingestion and intense resistance training minimize postexercise hypotension in normotensive and prehypertensive men.
Author TA Astorino,BJ Martin,L Schachtsiek,K Wong,
Country
Year 2013
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Cardiovascular Design
Design Details
Question... Follow Up Answer Follow-up Answer
What outcome is being evaluated in this paper? Cardiovascular
  • Comments Comments (
    0
    ) |
What is the objective of the study (as reported by the authors)? The primary aim of the study was to compare changes in blood pressure (BP) in normotensive and prehypertensive men completing resistance exercise following caffeine ingestion. To date, no study has examined discrepancies in cardiovascular function after caffeine ingestion in men with varying BP status completing resistance training, or examined onset of PEH after caffeine ingestion. It was hypothesized that HR and systolic BP would be significantly higher at rest, during exercise, and recovery with caffeine versus placebo, that this pressor effect would be greater in prehypertensives versus normotensives, and that PEH would occur after caffeine ingestion.
  • Comments Comments (
    0
    ) |
Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) During subsequent trials, anhydrous CAF or placebo (dimethyl cellulose) was provided to subjects in identical capsules and was ingested with water 1 h pretrial. These were prepared by a pharmacist with no involvement in the study. The dose was equal to 6 mg/kg, which maximizes blood levels of caffeine (Graham & Spriet, 1995) and enhances exercise performance (Astorino & Roberson, 2010). A double-blind, counterbalanced crossover design was used, as neither investigators nor subjects were aware of treatment order. After refraining from caffeine and intense exercise for 48 h, subjects returned 1 wk later at the same time of day. Initially, HR and BP were obtained twice after 5 min of seated rest. The first and fifth Korotkoff sounds were recorded via manual sphygmomanometry to determine systolic/diastolic BP. Pilot work revealed intraclass correlations for resting, exercise, and postexercise blood pressure equal to 0.98, 0.93, and 0.92, respectively. They sat alone in a quiet laboratory (21–23◦C, 40–50% RH) for 30 min, and measurements were obtained every 10 min. Subjects walked 8 min to the fitness center to initiate the exercise protocol. They completed a warm-up set equal to 8–10 repetitions of the bench press, then completed four sets of as many repetitions as possible, with 2 min recovery between sets. All sets were at 70 (bench press and shoulder press) or 80 (leg press and lat row) %1-RM. After set 2, HR was recorded immediately after exercise, followed by BP assessment with subjects remaining seated approximately 10 s after exercise (Astorino et al., 2008). A similar protocol was employed for the other exercises, with the entire bout lasting 1 h. Postexercise, subjects returned to the lab and sat alone in a quiet room for 75 min, with HR and BP measured every 25 min following similar procedures. Subjects returned 1 wk later and repeated the identical protocol after ingestion of the other treatment. After this trial, they completed a survey containing questions regarding health status, onset of side effects, and if they could identify the CAF trial.
  • Comments Comments (
    0
    ) |
How many outcome-specific endpoints are evaluated? 2
  • Comments Comments (
    0
    ) |
What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) Heart rate
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately). 2 Blood pressure (systolic and diastolic)
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).3
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).4
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).5
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).6
  • Comments Comments (
    0
    ) |
Clinical, physiological, other Physiological
  • Comments Comments (
    0
    ) |
What is the study design? Controlled Trial
  • Comments Comments (
    0
    ) |
Randomized or Non-Randomized? NCT
  • Comments Comments (
    0
    ) |
What were the diagnostics or methods used to measure the outcome? Objective
  • Comments Comments (
    0
    ) |
Optional: Name of Method or short description HR (Polar Electro, Woodbury, NY) and BP (adult Tru-Gage cuff, Omron HealthCare Inc., Vernon Hills, IL) were measured.
  • Comments Comments (
    0
    ) |
Caffeine (general) Caffeine (general)
  • Comments Comments (
    0
    ) |
Coffee, Chocolate, energy drink, gum, medicine/supplement, soda, tea, other?
  • Comments Comments (
    0
    ) |
Measured or self reported? Measured
  • Comments Comments (
    0
    ) |
Children, adolescents, adults, or pregnant included? Adults
  • Comments Comments (
    0
    ) |
What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) Placebo+exercise vs. 6 mg/kg caffeine+exercise (467.4 mg based on group's mean body weight)
  • Comments Comments (
    0
    ) |
What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) A 2 (treatment) x 11 (time, signifying four measurements preexercise, four during exercise, and three in recovery) x 2 (group) ANOVA with repeated measures was used to examine differences in HR and systolic and diastolic BP between CAF and placebo and across groups. A 2 (treatment) x 4 (sets) ANOVA with repeated measures was used to examine performance changes between CAF and placebo.
  • Comments Comments (
    0
    ) |
What conflicts of interest were reported? Not discussed.
  • Comments Comments (
    0
    ) |
Refid 23286422
  • Comments Comments (
    0
    ) |
What were the sources of funding? Not discussed.
  • Comments Comments (
    0
    ) |




Results & Comparisons

No Results found.