Study Title and Description
Caffeine poisoning and lactate rise: an overlooked toxic effect?
Key Questions Addressed
|1||For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on acute toxicity*?|
Primary Publication Information
|Title||Caffeine poisoning and lactate rise: an overlooked toxic effect?|
|Author||A Schmidt,C Karlson-Stiber,|
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Acute Toxicity - Study Design Details
No arms have been defined in this extraction form.
|Question... Follow Up||Answer||Follow-up Answer|
|What outcome is being evaluated in this paper?||Acute|
|What is the objective of the study (as reported by the authors)?||present a case report of sever caffeine poisoning with a concomitant rise in lactate treated with a non-selective Beta-blocker|
|Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods)||admitted to emergency room, gastric lavage, vital signs measured, ECG, labs normal except hypokalemia (2.4 mmol/l and lactate of 3.1 mmol/l. Looked for evidence of seizures, hypo perfusion, hypoxameia, sepsis and found none. Treated for anxiety and nausea, locate peaked at 7 mmol/l..treated with propranolol orally and patient recovered uneventfully.|
|How many outcome-specific endpoints are evaluated?||4|
|What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately)||overall condition: anxiety, tremors, hyperventilation|
|List additional health endpoints (separately).|
|List additional health endpoints (separately)|
|What is the study design?||Case report|
|Randomized or Non-Randomized?|
|What were the diagnostics or methods used to measure the outcome?||Both|
|Optional: Name of Method or short description||Standard tests were run (ECG and lab work) but observations were noted as well|
|Caffeine (general)||Caffeine (general)|
|What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.)||no this was a case report - suicide attempt|
|What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models. Copy from methods)||Authors noted that they looked for evidence of seizures, hypo perfusion, hypoxemia and sepsis and also the female admitted to no other ingestion - they pumped the stomach and found evidence of tablets.|
|Provide a general description of results (as reported by the authors).||upon admittance significant hypokalemia (2.4 mmol/L), repeat vomiting,nausea, hyperventilation, tachycardia measured by ECG (normal overall), lab values were normal except hypokalemia (2.4mmol/l) and lactate (3.1 mmol/l) which rose to 7.0mmol/l 9 hours post ingestion. Onadanestron and midazlolam iv given for nausea and anxiety and hypokalemia corrected, Propranolol 10mg was given orally lactate peaked and normalized. Patient recovered uneventfully.|
|Did the authors perform a dose-response analysis (or trend/related analysis)?||No|
|What were the authors's observations re: trend analysis?|
|What were the author's conclusions?||serious caffeine intoxication can give rise to lactatemia and lactic acidosis. a small dose non-selective beta blocker should be considered in treatment by physicians treating patients poisoned by caffeine.|
|What were the sources of funding?||none reported|
|What conflicts of interest were reported?||none reported|
|Does the exposure (dose) need to be standardized to the SR?||No|
|Provide calculations/conversions for the exposure based on the decision tree in the guide (for all endpoints/exposure levels of interest).|
|List all the endpoint(s) followed by the dose (mg) which will be used in comparison to Nawrot. Characterize value as LOAEL/NOAEL, etc. if possible.||caffeine intoxication (hypokalemia, nausea, repeat vomitting, termor/anxiety, hyperventilation, tachycardia) 12 g/day|
|Notes regarding selection/listing of endpoints and exposures/doses to be compared to Nawrot.|
|What is the importance of the study with respect to the adverseness of the outcome?||Important|
No baseline characteristics have been defined for this extraction form.
Results & Comparisons
No Results found.
|Arm or Total||Title||Description||Comments|
No quality dimensions were specified.
No quality rating data was found.