Advanced Search

Study Preview



Study Title and Description

Caffeine poisoning and lactate rise: an overlooked toxic effect?



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on acute toxicity*?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Caffeine poisoning and lactate rise: an overlooked toxic effect?
Author A Schmidt,C Karlson-Stiber,
Country
Year 2008
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Acute Toxicity - Study Design Details
Arms
No arms have been defined in this extraction form.

Design Details
Question... Follow Up Answer Follow-up Answer
Refid 18494847
  • Comments Comments (
    0
    ) |
What outcome is being evaluated in this paper? Acute
  • Comments Comments (
    0
    ) |
What is the objective of the study (as reported by the authors)? present a case report of sever caffeine poisoning with a concomitant rise in lactate treated with a non-selective Beta-blocker
  • Comments Comments (
    0
    ) |
Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) admitted to emergency room, gastric lavage, vital signs measured, ECG, labs normal except hypokalemia (2.4 mmol/l and lactate of 3.1 mmol/l. Looked for evidence of seizures, hypo perfusion, hypoxameia, sepsis and found none. Treated for anxiety and nausea, locate peaked at 7 mmol/l..treated with propranolol orally and patient recovered uneventfully.
  • Comments Comments (
    0
    ) |
How many outcome-specific endpoints are evaluated? 4
  • Comments Comments (
    0
    ) |
What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) overall condition: anxiety, tremors, hyperventilation
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately).
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately)
  • Comments Comments (
    0
    ) |
Notes
  • Comments Comments (
    0
    ) |
Clinical Clinical
  • Comments Comments (
    0
    ) |
Physiological Physiological
  • Comments Comments (
    0
    ) |
Other
  • Comments Comments (
    0
    ) |
What is the study design? Case report
  • Comments Comments (
    0
    ) |
Randomized or Non-Randomized?
  • Comments Comments (
    0
    ) |
What were the diagnostics or methods used to measure the outcome? Both
  • Comments Comments (
    0
    ) |
Optional: Name of Method or short description Standard tests were run (ECG and lab work) but observations were noted as well
  • Comments Comments (
    0
    ) |
Caffeine (general) Caffeine (general)
  • Comments Comments (
    0
    ) |
Coffee
  • Comments Comments (
    0
    ) |
Chocolate
  • Comments Comments (
    0
    ) |
Energy drinks
  • Comments Comments (
    0
    ) |
Gum
  • Comments Comments (
    0
    ) |
Medicine/Supplement Medicine/Supplement
  • Comments Comments (
    0
    ) |
Soda
  • Comments Comments (
    0
    ) |
Tea
  • Comments Comments (
    0
    ) |
Measured Measured
  • Comments Comments (
    0
    ) |
Self-report Self-report
  • Comments Comments (
    0
    ) |
Children
  • Comments Comments (
    0
    ) |
Adolescents Adolescents
  • Comments Comments (
    0
    ) |
Adults
  • Comments Comments (
    0
    ) |
Pregnant Women
  • Comments Comments (
    0
    ) |
What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) no this was a case report - suicide attempt
  • Comments Comments (
    0
    ) |
What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) Authors noted that they looked for evidence of seizures, hypo perfusion, hypoxemia and sepsis and also the female admitted to no other ingestion - they pumped the stomach and found evidence of tablets.
  • Comments Comments (
    0
    ) |
Provide a general description of results (as reported by the authors). upon admittance significant hypokalemia (2.4 mmol/L), repeat vomiting,nausea, hyperventilation, tachycardia measured by ECG (normal overall), lab values were normal except hypokalemia (2.4mmol/l) and lactate (3.1 mmol/l) which rose to 7.0mmol/l 9 hours post ingestion. Onadanestron and midazlolam iv given for nausea and anxiety and hypokalemia corrected, Propranolol 10mg was given orally lactate peaked and normalized. Patient recovered uneventfully.
  • Comments Comments (
    0
    ) |
Did the authors perform a dose-response analysis (or trend/related analysis)? No
  • Comments Comments (
    0
    ) |
What were the authors's observations re: trend analysis?
  • Comments Comments (
    0
    ) |
What were the author's conclusions? serious caffeine intoxication can give rise to lactatemia and lactic acidosis. a small dose non-selective beta blocker should be considered in treatment by physicians treating patients poisoned by caffeine.
  • Comments Comments (
    0
    ) |
What were the sources of funding? none reported
  • Comments Comments (
    0
    ) |
What conflicts of interest were reported? none reported
  • Comments Comments (
    0
    ) |
Does the exposure (dose) need to be standardized to the SR? No
  • Comments Comments (
    0
    ) |
Provide calculations/conversions for the exposure based on the decision tree in the guide (for all endpoints/exposure levels of interest).
  • Comments Comments (
    0
    ) |
List all the endpoint(s) followed by the dose (mg) which will be used in comparison to Nawrot.  Characterize value as LOAEL/NOAEL, etc. if possible.  caffeine intoxication (hypokalemia, nausea, repeat vomitting, termor/anxiety, hyperventilation, tachycardia) 12 g/day
  • Comments Comments (
    0
    ) |
Notes regarding selection/listing of endpoints and exposures/doses to be compared to Nawrot.
  • Comments Comments (
    0
    ) |
What is the importance of the study with respect to the adverseness of the outcome? Important
  • Comments Comments (
    0
    ) |


Baseline Characteristics
No baseline characteristics have been defined for this extraction form.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
No quality dimensions were specified.

Quality Rating
No quality rating data was found.