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Study Title and Description

A case of caffeine-induced coronary artery vasospasm of a 17-year-old male.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on acute toxicity*?
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Primary Publication Information
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TitleData
Title A case of caffeine-induced coronary artery vasospasm of a 17-year-old male.
Author RE Wilson,HS Kado,R Samson,AB Miller,
Country
Year 2012
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Acute Toxicity - Study Design Details
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Refid 22231478
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What outcome is being evaluated in this paper? Acute
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What is the objective of the study (as reported by the authors)? report on a 17 year old who presented with angina and abnormal ECG concerning for myocardial infarction; elevated cardiac enzymes after excessive consumption of caffeinated beverages.
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) authors utilized observation, ECG and urinalysis
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How many outcome-specific endpoints are evaluated? 5
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) angina (sharp left side chest pain)/abnormal ECG; diagnosis of acute coronary vasospasm diagnosed as result of caffeine intoxication
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List additional health endpoints (separately). family history
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List additional health endpoints (separately)
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Notes
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Clinical Clinical
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Physiological Physiological
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Other
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What is the study design? Case report
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Randomized or Non-Randomized?
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What were the diagnostics or methods used to measure the outcome? Both
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Optional: Name of Method or short description
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Caffeine (general)
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Coffee
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Chocolate
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Energy drinks Energy drinks
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Gum
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Medicine/Supplement
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Soda
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Tea
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Measured
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Self-report Self-report
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Children
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Adolescents Adolescents
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Adults
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Pregnant Women
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) none- case report
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) family history noted absence of early cardiac problems, no drug use (confirmed through urinalysis); potential early misdiagnosis of pericarditis following viral infection
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Provide a general description of results (as reported by the authors). patient presented with angina, diffuse ECG changes, elevated cardiac enzymes, coronary vasospasms, X-ray confirmed no cardiopulmonary disease, transthoracic echocardiogram no evidence of pericardial effusion, hypokalemia was manifest as well as elevated troponin all of which resolved upon treatment. Nuclear stress test did not show any indication of ischemia which is consistent with brief vasospasm. Medical history indicated questionable pericarditis which authors think might have been misdiagnosed following a viral infection
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Did the authors perform a dose-response analysis (or trend/related analysis)? No
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What were the authors's observations re: trend analysis?
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What were the author's conclusions? diagnosis of acute coronary vasospasm as a result of caffeine intoxication
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What were the sources of funding? non reported
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What conflicts of interest were reported? none reported
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Does the exposure (dose) need to be standardized to the SR? Multiple metrics
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Provide calculations/conversions for the exposure based on the decision tree in the guide (for all endpoints/exposure levels of interest). Redbulls (3-4cans)x80mg/can = 240-320mg caffeine Monster energy (2-3 cans) x 160 mg/can = 320-480 mg caffeine Total = 560 - 800 mg
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List all the endpoint(s) followed by the dose (mg) which will be used in comparison to Nawrot.  Characterize value as LOAEL/NOAEL, etc. if possible.  coronary vasospasm (560-800mg)
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Notes regarding selection/listing of endpoints and exposures/doses to be compared to Nawrot.
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What is the importance of the study with respect to the adverseness of the outcome? Important
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Baseline Characteristics
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