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Study Title and Description

A case of acute suicidality following excessive caffeine intake.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on acute toxicity*?
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Primary Publication Information
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TitleData
Title A case of acute suicidality following excessive caffeine intake.
Author A Szpak,D Allen,
Country
Year 2012
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Acute Toxicity - Study Design Details
Arms
No arms have been defined in this extraction form.

Design Details
Question... Follow Up Answer Follow-up Answer
Refid 22472312
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What outcome is being evaluated in this paper? Acute
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What is the objective of the study (as reported by the authors)? case report of an otherwise healthy 28 year old male who tried to kill himself (suffered mania)
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Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) neurological exam, psychiatry exams, minimentalstate exam, computed tomography all assessed to evaluate acute behavioral change
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How many outcome-specific endpoints are evaluated? 4
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What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) neurological exam = normal
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List additional health endpoints (separately).
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List additional health endpoints (separately)
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Notes patient consumed 14 cans of energy drink (0.012% caffeine), didn't sleep for 72 hours then attempted suicide
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Clinical Clinical
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Physiological Physiological
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Other
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What is the study design? Case report
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Randomized or Non-Randomized?
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What were the diagnostics or methods used to measure the outcome? Both
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Optional: Name of Method or short description
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Caffeine (general)
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Coffee
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Chocolate
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Energy drinks Energy drinks
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Gum
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Medicine/Supplement
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Soda
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Tea
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Measured
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Self-report Self-report
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Children
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Adolescents
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Adults Adults
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Pregnant Women
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What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) none case report
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What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) authors discussed previous history in family and discuss glucuronolactone and taurine but in the context of EFSA setting a NOAEL of 1000 mg/kg
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Provide a general description of results (as reported by the authors). observations: when found semiconscious, no recall of what triggered suicide attempt (no indication of prior thoughts). Neurological exam and computed tomography scan were normal, assessment by psychiatrist confirmed no evidence of depression, mania, anxiety of suicidal ideation, MMSE was 30/30 , reported complete memory loss.
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Did the authors perform a dose-response analysis (or trend/related analysis)? No
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What were the authors's observations re: trend analysis?
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What were the author's conclusions? potential fatality from an unpremeditated suicide attempt that is linked to excessive caffeine intake
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What were the sources of funding? stated as no specific grants of concern
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What conflicts of interest were reported? stated as none
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Does the exposure (dose) need to be standardized to the SR? No
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Provide calculations/conversions for the exposure based on the decision tree in the guide (for all endpoints/exposure levels of interest).
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List all the endpoint(s) followed by the dose (mg) which will be used in comparison to Nawrot.  Characterize value as LOAEL/NOAEL, etc. if possible.  failed suicide attempt = 560 mg/day, for two days
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Notes regarding selection/listing of endpoints and exposures/doses to be compared to Nawrot. not much detail was given on case itself- long discussion about DSM IV
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What is the importance of the study with respect to the adverseness of the outcome? Low
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Baseline Characteristics
No baseline characteristics have been defined for this extraction form.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
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Quality Rating
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