Study Title and Description
Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure.
Key Questions Addressed
|1||For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on acute toxicity*?|
Primary Publication Information
|Title||Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure.|
|Author||C Campana,PL Griffin,EL Simon,|
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: Acute Toxicity - Study Design Details
No arms have been defined in this extraction form.
|Question... Follow Up||Answer||Follow-up Answer|
|What outcome is being evaluated in this paper?||Acute|
|What is the objective of the study (as reported by the authors)?||We present the first reported case of a man with delayed presentation to the emergency department after ingesting 24g of caffeine in a suicide attempt who suffered complications of severe rhabdomyolysis and acute renal failure requiring subsequent hemodialysis.|
|Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods)||NA - case report|
|How many outcome-specific endpoints are evaluated?||6|
|What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately)||gastrointestinal dysfunction|
|List additional health endpoints (separately).||Loss of conciousness|
|List additional health endpoints (separately)||Dysrhythmia|
|Notes||gastrointestinal dysfunction was described as uncontrollable vomiting and diarrhea.|
|What is the study design?||Case report|
|Randomized or Non-Randomized?|
|What were the diagnostics or methods used to measure the outcome?||Objective|
|Optional: Name of Method or short description|
|What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.)||NA - case report|
|What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models. Copy from methods)||NA|
|Provide a general description of results (as reported by the authors).||The patient’s presentation and course were consistent with caffeine overdose, including nausea, vomiting, and restlessness. Lack of hypotension and dysrhythmia is likely due to the delay in presentation. The presence of rhabdomyolysis is interesting, and only 2 published cases exist of rhabdomyolysis after caffeine ingestion. In both cases, creatine kinase did not exceed 1200 U/L upon ED presentation. Our patient’s creatine kinase was 59,000 and is estimated to have been greater than 250,000 in days prior to ED presentation using Gabow’s series . This case is noteworthy in that he consumed a lethal dose of caffeine and survived even after sustaining severe rhabdomyolysis, acute renal failure, and hepatic injury.|
|Did the authors perform a dose-response analysis (or trend/related analysis)?||No|
|What were the authors's observations re: trend analysis?|
|What were the author's conclusions?||We present the first reported case of a man with delayed presentation to the emergency department after ingesting 24 g of caffeine in a suicide attempt who suffered complications of severe rhabdomyolysis and acute renal failure requiring subsequent hemodialysis. This case is noteworthy in that he consumed a lethal dose of caffeine and survived even after sustaining severe rhabdomyolysis, acute renal failure, and hepatic injury. This patient attempted suicide via caffeine overdose and suffered severe complications that included rhabdomyolysis and acute renal failure requiring hemodialysis. Despite consuming a "lethal" dosage, the patient did not suffer any documented dysrhythmias, the major cause of caffeine toxicity mortality.|
|What were the sources of funding?||NA|
|What conflicts of interest were reported?||NA|
|Does the exposure (dose) need to be standardized to the SR?||No|
|Provide calculations/conversions for the exposure based on the decision tree in the guide (for all endpoints/exposure levels of interest).|
|List all the endpoint(s) followed by the dose (mg) which will be used in comparison to Nawrot. Characterize value as LOAEL/NOAEL, etc. if possible.||Dysrhythmia NOAEL = 24 g Gastrointestinal dysfunction LOAEL = 24 g severe rhabdomyolysis LOAEL = 24 g acute renal failure LOAEL = 24 g hepatic injury LOAEL = 24g loss of consciousness LOAEL = 24g|
|Notes regarding selection/listing of endpoints and exposures/doses to be compared to Nawrot.|
|What is the importance of the study with respect to the adverseness of the outcome?||Critcal|
No baseline characteristics have been defined for this extraction form.
Results & Comparisons
No Results found.
|Arm or Total||Title||Description||Comments|
No quality dimensions were specified.
No quality rating data was found.