Advanced Search

Study Preview



Study Title and Description

Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure.



Key Questions Addressed
1 For [population], is caffeine intake above [exposure dose], compared to intakes [exposure dose] or less, associated with adverse effects on acute toxicity*?
  • Comments Comments (
    0
    ) |

Primary Publication Information
  • Comments Comments (
    0
    ) |
TitleData
Title Caffeine overdose resulting in severe rhabdomyolysis and acute renal failure.
Author C Campana,PL Griffin,EL Simon,
Country
Year 2014
Numbers

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Acute Toxicity - Study Design Details
Arms
No arms have been defined in this extraction form.

Design Details
Question... Follow Up Answer Follow-up Answer
Refid 24079989
  • Comments Comments (
    0
    ) |
What outcome is being evaluated in this paper? Acute
  • Comments Comments (
    0
    ) |
What is the objective of the study (as reported by the authors)? We present the first reported case of a man with delayed presentation to the emergency department after ingesting 24g of caffeine in a suicide attempt who suffered complications of severe rhabdomyolysis and acute renal failure requiring subsequent hemodialysis.
  • Comments Comments (
    0
    ) |
Provide a general description of the methods as reported by the authors. Information should be extracted based on relevance to the SR (i.e., caffeine related methods) NA - case report
  • Comments Comments (
    0
    ) |
How many outcome-specific endpoints are evaluated? 6
  • Comments Comments (
    0
    ) |
What is the (or one of the) endpoint(s) evaluated? (Each endpoint listed separately) gastrointestinal dysfunction
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately). Loss of conciousness
  • Comments Comments (
    0
    ) |
List additional health endpoints (separately) Dysrhythmia
  • Comments Comments (
    0
    ) |
Notes gastrointestinal dysfunction was described as uncontrollable vomiting and diarrhea.
  • Comments Comments (
    0
    ) |
Clinical
  • Comments Comments (
    0
    ) |
Physiological Physiological
  • Comments Comments (
    0
    ) |
Other
  • Comments Comments (
    0
    ) |
What is the study design? Case report
  • Comments Comments (
    0
    ) |
Randomized or Non-Randomized?
  • Comments Comments (
    0
    ) |
What were the diagnostics or methods used to measure the outcome? Objective
  • Comments Comments (
    0
    ) |
Optional: Name of Method or short description
  • Comments Comments (
    0
    ) |
Caffeine (general)
  • Comments Comments (
    0
    ) |
Coffee
  • Comments Comments (
    0
    ) |
Chocolate
  • Comments Comments (
    0
    ) |
Energy drinks
  • Comments Comments (
    0
    ) |
Gum
  • Comments Comments (
    0
    ) |
Medicine/Supplement Medicine/Supplement
  • Comments Comments (
    0
    ) |
Soda
  • Comments Comments (
    0
    ) |
Tea
  • Comments Comments (
    0
    ) |
Measured
  • Comments Comments (
    0
    ) |
Self-report Self-report
  • Comments Comments (
    0
    ) |
Children
  • Comments Comments (
    0
    ) |
Adolescents
  • Comments Comments (
    0
    ) |
Adults Adults
  • Comments Comments (
    0
    ) |
Pregnant Women
  • Comments Comments (
    0
    ) |
What was the reference, comparison, or control group(s)? (e.g. high vs low consumption, number of cups, etc.) NA - case report
  • Comments Comments (
    0
    ) |
What were the listed confounders or modifying factors as stated by the authors? (e.g. multi-variable components of models.  Copy from methods) NA
  • Comments Comments (
    0
    ) |
Provide a general description of results (as reported by the authors). The patient’s presentation and course were consistent with caffeine overdose, including nausea, vomiting, and restlessness. Lack of hypotension and dysrhythmia is likely due to the delay in presentation. The presence of rhabdomyolysis is interesting, and only 2 published cases exist of rhabdomyolysis after caffeine ingestion. In both cases, creatine kinase did not exceed 1200 U/L upon ED presentation. Our patient’s creatine kinase was 59,000 and is estimated to have been greater than 250,000 in days prior to ED presentation using Gabow’s series [9]. This case is noteworthy in that he consumed a lethal dose of caffeine and survived even after sustaining severe rhabdomyolysis, acute renal failure, and hepatic injury.
  • Comments Comments (
    0
    ) |
Did the authors perform a dose-response analysis (or trend/related analysis)? No
  • Comments Comments (
    0
    ) |
What were the authors's observations re: trend analysis?
  • Comments Comments (
    0
    ) |
What were the author's conclusions? We present the first reported case of a man with delayed presentation to the emergency department after ingesting 24 g of caffeine in a suicide attempt who suffered complications of severe rhabdomyolysis and acute renal failure requiring subsequent hemodialysis. This case is noteworthy in that he consumed a lethal dose of caffeine and survived even after sustaining severe rhabdomyolysis, acute renal failure, and hepatic injury. This patient attempted suicide via caffeine overdose and suffered severe complications that included rhabdomyolysis and acute renal failure requiring hemodialysis. Despite consuming a "lethal" dosage, the patient did not suffer any documented dysrhythmias, the major cause of caffeine toxicity mortality.
  • Comments Comments (
    0
    ) |
What were the sources of funding? NA
  • Comments Comments (
    0
    ) |
What conflicts of interest were reported? NA
  • Comments Comments (
    0
    ) |
Does the exposure (dose) need to be standardized to the SR? No
  • Comments Comments (
    0
    ) |
Provide calculations/conversions for the exposure based on the decision tree in the guide (for all endpoints/exposure levels of interest).
  • Comments Comments (
    0
    ) |
List all the endpoint(s) followed by the dose (mg) which will be used in comparison to Nawrot.  Characterize value as LOAEL/NOAEL, etc. if possible.  Dysrhythmia NOAEL = 24 g Gastrointestinal dysfunction LOAEL = 24 g severe rhabdomyolysis LOAEL = 24 g acute renal failure LOAEL = 24 g hepatic injury LOAEL = 24g loss of consciousness LOAEL = 24g
  • Comments Comments (
    0
    ) |
Notes regarding selection/listing of endpoints and exposures/doses to be compared to Nawrot.
  • Comments Comments (
    0
    ) |
What is the importance of the study with respect to the adverseness of the outcome? Critcal
  • Comments Comments (
    0
    ) |


Baseline Characteristics
No baseline characteristics have been defined for this extraction form.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
No quality dimensions were specified.

Quality Rating
No quality rating data was found.