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Project: Treatment of Depression in Children and Adolescents: A Systematic Review

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Project Summary

Title and Description


Key Questions


Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Study Data for this published project can be accessed from the SRDR Published Projects page, under the Show Downloadable Content section of this project Sara Kennedy 1, 2, 3, 4, 5, 6, 7, 8, 9, 10


Associated Studies (each link opens a new tab)

Title Author Year
A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence M. C. Tompson, C. A. Sugar, D. A. Langer and J. R. Asarnow 2017
Cognitive-behavioural therapy and short-term psychoanalytic psychotherapy versus brief psychosocial intervention in adolescents with unipolar major depression (IMPACT): a multicentre, pragmatic, observer-blind, randomised controlled trial I. M. Goodyer, S. Reynolds, B. Barrett, S. Byford, B. Dubicka, J. Hill, F. Holland, R. Kelvin, N. Midgley, C. Roberts, R. Senior, M. Target, B. Widmer, P. Wilkinson and P. Fonagy 2017
Study 329 continuation phase: safety and efficacy of paroxetine and imipramine in extended treatment of adolescent major depression J. Le Noury, J. M. Nardo, D. Healy, J. Jureidini, M. Raven, C. Tufanaru and E. Abi-Jaoude 2016
Cognitive behavioral therapy in primary care for youth declining antidepressants: a randomized trial G. Clarke, L. L. DeBar, J. A. Pearson, J. F. Dickerson, F. L. Lynch, C. M. Gullion and M. C. Leo 2016
Evaluation of a spirituality informed e-mental health tool as an intervention for major depressive disorder in adolescents and young adults - a randomized controlled pilot trial B. Rickhi, A. Kania-Richmond, S. Moritz, J. Cohen, P. Paccagnan, C. Dennis, M. Liu, S. Malhotra, P. Steele and J. Toews 2015
Family-based interpersonal psychotherapy for depressed preadolescents: examining efficacy and potential treatment mechanisms L. J. Dietz, R. J. Weinberg, D. A. Brent and L. Mufson 2015
A double-blind, placebo-controlled study of selegiline transdermal system in depressed adolescents M. P. DelBello, T. J. Hochadel, K. B. Portland, A. J. Azzaro, A. Katic, A. Khan and G. Emslie 2014
Sequential treatment with fluoxetine and relapse--prevention CBT to improve outcomes in pediatric depression B. D. Kennard, G. J. Emslie, T. L. Mayes, P. A. Nakonezny, J. M. Jones, A. A. Foxwell and J. King 2014
Concurrent treatment for adolescent and parent depressed mood and suicidality: feasibility, acceptability, and preliminary findings A. Spirito, J. C. Wolff, L. M. Seaboyer, J. Hunt, C. Esposito-Smythers, N. Nugent, C. Zlotnick and I. Miller 2015
A double-blind efficacy and safety study of duloxetine fixed doses in children and adolescents with major depressive disorder G. J. Emslie, A. Prakash, Q. Zhang, B. A. Pangallo, M. E. Bangs and J. S. March 2014
A double-blind efficacy and safety study of duloxetine flexible dosing in children and adolescents with major depressive disorder S. D. Atkinson, A. Prakash, Q. Zhang, B. A. Pangallo, M. E. Bangs, G. J. Emslie and J. S. March 2014
Social problem solving among depressed adolescents is enhanced by structured psychotherapies L. J. Dietz, M. P. Marshal, C. M. Burton, J. A. Bridge, B. Birmaher, D. Kolko, J. N. Duffy and D. A. Brent 2014
Cognitive behavioral therapy for depressed adolescents exposed to interpersonal trauma: an initial effectiveness trial S. R. Shirk, A. P. Deprince, P. S. Crisostomo and J. Labus 2014
Escitalopram in the treatment of adolescent depression: a randomized, double-blind, placebo-controlled extension trial R. L. Findling, A. Robb and A. Bose 2013
Moderators of fluoxetine treatment response for children and adolescents with comorbid depression and substance use disorders M. E. Hirschtritt, M. E. Pagano, K. M. Christian, N. K. McNamara, R. J. Stansbrey, J. Lingler, J. E. Faber, C. A. Demeter, D. Bedoya and R. L. Findling 2012
A novel early intervention for preschool depression: findings from a pilot randomized controlled trial J. Luby, S. Lenze and R. Tillman 2012
Predictors of spontaneous and systematically assessed suicidal adverse events in the treatment of SSRI-resistant depression in adolescents (TORDIA) study D. A. Brent, G. J. Emslie, G. N. Clarke, J. Asarnow, A. Spirito, L. Ritz, B. Vitiello, S. Iyengar, B. Birmaher, N. D. Ryan, J. Zelazny, M. Onorato, B. Kennard, T. L. Mayes, L. L. Debar, J. T. McCracken, M. Strober, R. Suddath, H. Leonard, G. Porta and M. B. Keller 2009
Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response J. R. Asarnow, G. Emslie, G. Clarke, K. D. Wagner, A. Spirito, B. Vitiello, S. Iyengar, W. Shamseddeen, L. Ritz, J. McCracken, M. Strober, R. Suddath, H. Leonard, G. Porta, M. Keller and D. Brent 2009
Cognitive-behavioral therapy to prevent relapse in pediatric responders to pharmacotherapy for major depressive disorder B. D. Kennard, G. J. Emslie, T. L. Mayes, J. Nightingale-Teresi, P. A. Nakonezny, J. L. Hughes, J. M. Jones, R. Tao, S. M. Stewart and R. B. Jarrett 2008
Family-based interpersonal psychotherapy for depressed preadolescents: an open-treatment trial L. J. Dietz, L. Mufson, H. Irvine and D. A. Brent 2008
Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial D. Brent, G. Emslie, G. Clarke, K. D. Wagner, J. R. Asarnow, M. Keller, B. Vitiello, L. Ritz, S. Iyengar, K. Abebe, B. Birmaher, N. Ryan, B. Kennard, C. Hughes, L. DeBar, J. McCracken, M. Strober, R. Suddath, A. Spirito, H. Leonard, N. Melhem, G. Porta, M. Onorato and J. Zelazny 2008
Childhood depression: a place for psychotherapy. An outcome study comparing individual psychodynamic psychotherapy and family therapy J. Trowell, I. Joffe, J. Campbell, C. Clemente, F. Almqvist, M. Soininen, U. Koskenranta-Aalto, S. Weintraub, G. Kolaitis, V. Tomaras, D. Anastasopoulos, K. Grayson, J. Barnes and J. Tsiantis 2007
Treatment for Adolescents with Depression Study (TADS): safety results G. Emslie, C. Kratochvil, B. Vitiello, S. Silva, T. Mayes, S. McNulty, E. Weller, B. Waslick, C. Casat, J. Walkup, S. Pathak, P. Rohde, K. Posner and J. March 2006
Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS) J. Curry, P. Rohde, A. Simons, S. Silva, B. Vitiello, C. Kratochvil, M. Reinecke, N. Feeny, K. Wells, S. Pathak, E. Weller, D. Rosenberg, B. Kennard, M. Robins, G. Ginsburg and J. March 2006
Functioning and quality of life in the Treatment for Adolescents with Depression Study (TADS) B. Vitiello, P. Rohde, S. Silva, K. Wells, C. Casat, B. Waslick, A. Simons, M. Reinecke, E. Weller, C. Kratochvil, J. Walkup, S. Pathak, M. Robins and J. March 2006
Acute time to response in the Treatment for Adolescents with Depression Study (TADS) C. Kratochvil, G. Emslie, S. Silva, S. McNulty, J. Walkup, J. Curry, M. Reinecke, B. Vitiello, P. Rohde, N. Feeny, C. Casat, S. Pathak, E. Weller, D. May, T. Mayes, M. Robins and J. March 2006
Remission and residual symptoms after short-term treatment in the Treatment of Adolescents with Depression Study (TADS) B. Kennard, S. Silva, B. Vitiello, J. Curry, C. Kratochvil, A. Simons, J. Hughes, N. Feeny, E. Weller, M. Sweeney, M. Reinecke, S. Pathak, G. Ginsburg, G. Emslie and J. March 2006
A comparison of cognitive-behavioral therapy, sertraline, and their combination for adolescent depression G. A. Melvin, B. J. Tonge, N. J. King, D. Heyne, M. S. Gordon and E. Klimkeit 2006
Omega-3 treatment of childhood depression: a controlled, double-blind pilot study H. Nemets, B. Nemets, A. Apter, Z. Bracha and R. H. Belmaker 2006
Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, double-blind, placebo-controlled trial G. J. Emslie, K. D. Wagner, S. Kutcher, S. Krulewicz, R. Fong, D. J. Carpenter, A. Lipschitz, A. Machin and C. Wilkinson 2006
Fluoxetine 40-60 mg versus fluoxetine 20 mg in the treatment of children and adolescents with a less-than-complete response to nine-week treatment with fluoxetine 10-20 mg: a pilot study J. H. Heiligenstein, S. L. Hoog, K. D. Wagner, R. L. Findling, N. Galil, S. Kaplan, J. Busner, M. E. Nilsson, E. B. Brown and J. G. Jacobson 2006
An international, multicenter, placebo-controlled trial of paroxetine in adolescents with major depressive disorder R. Berard, R. Fong, D. J. Carpenter, C. Thomason and C. Wilkinson 2006
A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depression K. D. Wagner, J. Jonas, R. L. Findling, D. Ventura and K. Saikali 2006
A randomized effectiveness trial of brief cognitive-behavioral therapy for depressed adolescents receiving antidepressant medication G. Clarke, L. Debar, F. Lynch, J. Powell, J. Gale, E. O'Connor, E. Ludman, T. Bush, E. H. Lin, M. Von Korff and S. Hertert 2005
Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled study G. J. Emslie, J. H. Heiligenstein, S. L. Hoog, K. D. Wagner, R. L. Findling, J. T. McCracken, M. E. Nilsson and J. G. Jacobson 2004
Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents With Depression Study (TADS) randomized controlled trial J. March, S. Silva, S. Petrycki, J. Curry, K. Wells, J. Fairbank, B. Burns, M. Domino, S. McNulty, B. Vitiello and J. Severe 2004
A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents K. D. Wagner, A. S. Robb, R. L. Findling, J. Jin, M. M. Gutierrez and W. E. Heydorn 2004
An efficacy/effectiveness study of cognitive-behavioral treatment for adolescents with comorbid major depression and conduct disorder P. Rohde, G. N. Clarke, D. E. Mace, J. S. Jorgensen and J. R. Seeley 2004
Suicidality and its relationship to treatment outcome in depressed adolescents R. P. Barbe, J. Bridge, B. Birmaher, D. Kolko and D. A. Brent 2004
Lifetime history of sexual abuse, clinical presentation, and outcome in a clinical trial for adolescent depression R. P. Barbe, J. A. Bridge, B. Birmaher, D. J. Kolko and D. A. Brent 2004
Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial G. J. Emslie, J. H. Heiligenstein, K. D. Wagner, S. L. Hoog, D. E. Ernest, E. Brown, M. Nilsson and J. G. Jacobson 2002
Attachment-based family therapy for depressed adolescents: a treatment development study G. S. Diamond, B. F. Reis, G. M. Diamond, L. Siqueland and L. Isaacs 2002
Group cognitive-behavioral treatment for depressed adolescent offspring of depressed parents in a health maintenance organization G. N. Clarke, M. Hornbrook, F. Lynch, M. Polen, J. Gale, E. O'Connor, J. R. Seeley and L. Debar 2002
Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial M. B. Keller, N. D. Ryan, M. Strober, R. G. Klein, S. P. Kutcher, B. Birmaher, O. R. Hagino, H. Koplewicz, G. A. Carlson, G. N. Clarke, G. J. Emslie, D. Feinberg, B. Geller, V. Kusumakar, G. Papatheodorou, W. H. Sack, M. Sweeney, K. D. Wagner, E. B. Weller, N. C. Winters, R. Oakes and J. P. McCafferty 2001
Imipramine compliance in adolescents G. A. Bernstein, L. K. Anderson, J. M. Hektner and G. M. Realmuto 2000
The efficacy of cognitive-behavioral and interpersonal treatments for depression in Puerto Rican adolescents J. Rossello and G. Bernal 1999
Efficacy of interpersonal psychotherapy for depressed adolescents L. Mufson, M. M. Weissman, D. Moreau and R. Garfinkel 1999
Cognitive-behavioral treatment of adolescent depression: efficacy of acute group treatment and booster sessions G. N. Clarke, P. Rohde, P. M. Lewinsohn, H. Hops and J. R. Seeley 1999
Predictors of treatment efficacy in a clinical trial of three psychosocial treatments for adolescent depression D. A. Brent, D. J. Kolko, B. Birmaher, M. Baugher, J. Bridge, C. Roth and D. Holder 1998
Adolescent depression: controlled desipramine treatment and atypical features R. G. Klein, S. Mannuzza, H. S. Koplewicz, N. K. Tancer, M. Shah, V. Liang and M. Davies 1998
A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression G. J. Emslie, A. J. Rush, W. A. Weinberg, R. A. Kowatch, C. W. Hughes, T. Carmody and J. Rintelmann 1997
A clinical psychotherapy trial for adolescent depression comparing cognitive, family, and supportive therapy D. A. Brent, D. Holder, D. Kolko, B. Birmaher, M. Baugher, C. Roth, S. Iyengar and B. A. Johnson 1997
Venlafaxine in the treatment of children and adolescents with major depression M. W. Mandoki, M. R. Tapia, M. A. Tapia, G. S. Sumner and J. L. Parker 1997
A randomized, controlled trial of amitriptyline in the acute treatment of adolescent major depression C. H. Kye, G. S. Waterman, N. D. Ryan, B. Birmaher, D. E. Williamson, S. Iyengar and S. Dachille 1996
Response of depressed adolescents to cognitive-behavioral treatment: do differences in initial severity clarify the comparison of treatments? P. Rohde, P. M. Lewinsohn and J. R. Seeley 1994
Pharmacokinetically designed double-blind placebo-controlled study of nortriptyline in 6- to 12-year-olds with major depressive disorder B. Geller, T. B. Cooper, D. L. Graham, H. H. Fetner, F. A. Marsteller and J. M. Wells 1992
Cognitive behavioural therapy and short-term psychoanalytical psychotherapy versus a brief psychosocial intervention in adolescents with unipolar major depressive disorder (IMPACT): a multicentre, pragmatic, observer-blind, randomised controlled superiority trial I. M. Goodyer, S. Reynolds, B. Barrett, S. Byford, B. Dubicka, J. Hill, F. Holland, R. Kelvin, N. Midgley, C. Roberts, R. Senior, M. Target, B. Widmer, P. Wilkinson and P. Fonagy 2017
Treatment response in depressed adolescents with and without co-morbid attention-deficit/hyperactivity disorder in the Treatment for Adolescents with Depression Study C. J. Kratochvil, D. E. May, S. G. Silva, V. Madaan, S. E. Puumala, J. F. Curry, J. Walkup, H. Kepley, B. Vitiello and J. S. March 2009
The effects of cognitive-behavioural therapy on mood-related ruminative response style in depressed adolescents P. O. Wilkinson and I. M. Goodyer 2008
A phase 3, double-blind, randomized, placebo-controlled study of vilazodone in adolescents with major depressive disorder S. Durgam, C. Chen, R. Migliore, C. Prakash, J. Edwards and R. L. Findling 2018
Predictors and moderators of relapse in children and adolescents with major depressive disorder B. D. Kennard, T. L. Mayes, Z. Chahal, P. A. Nakonezny, A. Moorehead and G. J. Emslie 2018
Desvenlafaxine versus placebo in a fluoxetine-referenced study of children and adolescents with major depressive disorder K. L. Weihs, W. Murphy, R. Abbas, D. Chiles, R. D. England, S. Ramaker and D. B. Wajsbrot 2018
The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial R. L. Findling, M. E. Pagano, N. K. McNamara, R. J. Stansbrey, J. E. Faber, J. Lingler, C. A. Demeter, D. Bedoya and M. D. Reed 2009
Depressed Adolescents Treated with Exercise (DATE): a pilot randomized controlled trial to test feasibility and establish preliminary effect sizes C. W. Hughes, S. Barnes, C. Barnes, L. F. Defina, P. Nakonezny and G. J. Emslie 2013
Combined cognitive behavioral therapy and bupropion for the treatment of problematic on-line game play in adolescents with major depressive disorder S. M. Kim, D. H. Han, Y. S. Lee and P. F. Renshaw 2012
Clinical and psychosocial predictors of suicide attempts and nonsuicidal self-injury in the Adolescent Depression Antidepressants and Psychotherapy Trial (ADAPT) P. Wilkinson, R. Kelvin, C. Roberts, B. Dubicka and I. Goodyer 2011
Cognitive-behavioral therapy plus healthy lifestyle enhancement for depressed, overweight/obese adolescents: results of a pilot trial E. Jelalian, B. Jandasek, J. C. Wolff, L. M. Seaboyer, R. N. Jones and A. Spirito 2016
Cognitive behavioral therapy for childhood depression: a comparison of face-to-face and interactive televideo settings E. L. Nelson 2004
A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of citalopram in children and adolescents with depression Forest Laboratories 2001
A double-blind, multicentre placebo controlled study of paroxetine in adolescents with unipolar major depression GlaxoSmithKline 1998
Desvenlafaxine versus placebo in the treatment of children and adolescents with major depressive disorder S. Atkinson, S. Lubaczewski, S. Ramaker, R. D. England, D. B. Wajsbrot, R. Abbas and R. L. Findling 2018
Depressed youth: treatment outcome and changes in family functioning in individual and family therapy F. F. Garoff, K. Heinonen, A.-K. Pesonen and F. Almqvist 2012
Innovations in practice: a pilot study of interpersonal psychotherapy for depressed adolescents and their parents M. Gunlicks_Stoessel and L. Mufson 2016
Feasibility of Attachment Based Family Therapy for depressed clinic-referred Norwegian adolescents P. Israel and G. S. Diamond 2013
Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence J. L. Le Noury, J. M. Nardo, D. Healy, J. Jureidini, M. Raven, C. Tufanaru and E. Abi-Jaoude 2015
Double-blind, placebo-controlled study of nortriptyline in depressed children using a fixed plasma level design B. Geller, T. B. Cooper, H. G. McCombs, D. Graham and J. Wells 1989
A double-blind, placebo-controlled trial of sertraline in depressed adolescent alcoholics: a pilot study D. Deas, C. L. Randall, J. S. Roberts and R. F. Anton 2000
Treating a broader range of depressed adolescents with combined therapy S. Foster and M. Mohler-Kuo 2018
Estimating patient-specific treatment advantages in the 'Treatment for Adolescents with Depression Study' S. Foster, M. Mohler-Kuo, L. Tay, T. Hothorn and H. Seibold 2019
Pilot randomized controlled trial of Omega-3 and individual-family psychoeducational psychotherapy for children and adolescents with depression M. A. Fristad, A. T. Vesco, A. S. Young, K. Z. Healy, E. S. Nader, W. Gardner, A. M. Seidenfeld, H. L. Wolfson and L. E. Arnold 2019
Prognostic implications for adolescents with depression who drop out of psychological treatment during a randomized controlled trial S. O'Keeffe, P. Martin, I. M. Goodyer, R. Kelvin, B. Dubicka and N. Midgley 2019
Predicting dropout in adolescents receiving therapy for depression S. O'Keeffe, P. Martin, I. M. Goodyer, P. Wilkinson, I. Consortium and N. Midgley 2018
A randomized controlled trial of the impact of a family-based adolescent depression intervention on both youth and parent mental health outcomes L. A. Poole, T. Knight, J. W. Toumbourou, D. I. Lubman, M. D. Bertino and A. J. Lewis 2018
Depression in childhood: one year outcomes of family versus individual treatment J. R. Asarnow 57
Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS) C. C. Lewis, A. D. Simons, L. J. Nguyen, J. L. Murakami, M. W. Reid, S. G. Silva and J. S. March 2010
Escitalopram in the treatment of adolescent depression: a randomized placebo-controlled multisite trial G. J. Emslie, D. Ventura, A. Korotzer and S. Tourkodimitris 2009
Fluoxetine versus placebo in preventing relapse of major depression in children and adolescents G. J. Emslie, B. D. Kennard, T. L. Mayes, J. Nightingale-Teresi, T. Carmody, C. W. Hughes, A. J. Rush, R. Tao and J. W. Rintelmann 2008
Imipramine plus cognitive-behavioral therapy in the treatment of school refusal G. A. Bernstein, C. M. Borchardt, A. R. Perwien, R. D. Crosby, M. G. Kushner, P. D. Thuras and C. G. Last 2000
Predicting time to recovery among depressed adolescents treated in two psychosocial group interventions P. Rohde, J. R. Seeley, N. K. Kaufman, G. N. Clarke and E. Stice 2006
Attachment-based family therapy for depressed adolescents: programmatic treatment development G. Diamond, L. Siqueland and G. M. Diamond 2003
A multi_family group intervention for adolescent depression: the BEST MOOD program L. A. Poole, A. J. Lewis, J. W. Toumbourou, T. Knight, M. D. Bertino and R. Pryor 2017
Predictors of treatment response in anxious-depressed adolescents with school refusal A. E. Layne, G. A. Bernstein, E. A. Egan and M. G. Kushner 2003




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