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Study Title and Description

Plasma amino acids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements.



Key Questions Addressed
1 What is the effect of sugars on health outcomes in intervention studies?
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Primary Publication Information
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TitleData
Title Plasma amino acids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements.
Author Caballero B., Finer N., Wurtman RJ.
Country Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02142.
Year 1988
Numbers Pubmed ID: 3290625

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Sugar Evidence Map Intervention Studies
Arms
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Randomized Controlled Trial (parallel)
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Trial Name nr
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Funding Source nr
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Intervention (Exposure) Information Sucrose
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Sucrose
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Sucrose
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sucrose as carbohydrate source, lemon flavored snack
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sucrose as carbohydrate source, lemon flavored snack
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sucrose as carbohydrate source, lemon flavored snack
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30g
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50g
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75g
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4 one-day experiments, measurements taken hourly for 4 hours after administration
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Unclear
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Study Randomization Yes
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Yes
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Baseline Health Status all healthy and free of medication, 8 lean, 9 obese
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Sample Size 17 (8 lean, 9 obese)
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Anthropometry at Baseline lean; obese, kg/m2
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21.3; 38.7
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Male % nr
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Country United States
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Additional Comments or Questions 30g sucrose administered with 4 different doses of tryptophan, and then additional doses of sucrose were given (50g and 75g)
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Age ... Value Mean ... lean =30; obese =39
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Standard Deviation ... lean=4; obese=8
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Was a power calculation performed? No
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Was the study blinded? Unclear
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What is the study population? Adults
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Publication Year 1988
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