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Study Title and Description

Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial.



Key Questions Addressed
1 What is the effect of sugars on health outcomes in intervention studies?
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Primary Publication Information
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TitleData
Title Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial.
Author Silbernagel G., Machann J., Unmuth S., Schick F., Stefan N., Häring HU., Fritsche A.
Country Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Department of Internal Medicine, Eberhard-Karls-University Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, Germany.
Year 2011
Numbers Pubmed ID: 21396140
20024079-2 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Sugar Evidence Map Intervention Studies
Arms
Number Title Description Comments
1 Fructose
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2 Glucose
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Randomized Controlled Trial (parallel)
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Trial Name TUebingen Fructose Or Glucose (TUFROG) study
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Funding Source Grant from the German Research Foundation (KFO 114/2) and the Zentrum Ernahrungsmedizin Tubingen-Hohenheim. Funding did not include industrial sponsorship.
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Intervention (Exposure) Information Fructose
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dissolved in water
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150g/day
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4 weeks
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Supplement
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Study Randomization Yes
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Yes
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Comparator Information glucose
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150g/day
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Baseline Health Status healthy
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Sample Size 20
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Anthropometry at Baseline mean
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25.9
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Male % 60
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Country Germany
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Age ... Value Mean ... 30.5
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Standard Error ... 2
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Was a power calculation performed? Yes
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Was the study blinded? Yes
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Yes
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No
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No
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What is the study population? Adults
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Publication Year 2011
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Results & Comparisons


Results Data
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: weight      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -3.1
Mean 80.3 80.7 0.0
Standard Error 2.9 2.4 0.056
-1.5
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: Blood Pressure      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -11
Mean 120 114 7
Standard Error 4 4 0.628
0.1
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: Glucose (blood sugar)      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -0.34
Mean 4.82 4.9 0.30
Standard Error 0.1 0.07 0.884
-0.02
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: Insulin      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -28
Mean 45 51 15
Standard Error 12 7 0.529
-7
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: Total Cholesterol      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -6
Mean 1760 1750 25
Standard Error 70 80 0.23
9
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: Triglycerides      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 1
Mean 800 980 65
Standard Error 110 100 .045
33
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: HDL      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -5
Mean 540 530 2
Standard Error 30 30 .473
-1
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: LDL      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -6
Mean 1050 1080 21
Standard Error 50 90 0.24
8
95% Confidence Interval Lower Limit (95% LCI) 95% Confidence Interval Upper Limit (95% HCI) P-Value diff in LSM
Outcome: Blood Pressure      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure Fructose vs. Glucose


4 weeks

N Analyzed 10 10 -8
Mean 79 75 7
Standard Error 3 3 0.835
-1