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Study Title and Description

Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.



Key Questions Addressed
1 What is the effect of sugars on health outcomes in intervention studies?
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Primary Publication Information
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TitleData
Title Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
Author Stanhope KL., Schwarz JM., Keim NL., Griffen SC., Bremer AA., Graham JL., Hatcher B., Cox CL., Dyachenko A., Zhang W., McGahan JP., Seibert A., Krauss RM., Chiu S., Schaefer EJ., Ai M., Otokozawa S., Nakajima K., Nakano T., Beysen C., Hellerstein MK., Berglund L., Havel PJ.
Country Department of Molecular Biosciences, UCD, Davis, California 95616, USA.
Year 2009
Numbers Pubmed ID: 19381015
20032023 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Sugar Evidence Map Intervention Studies
Arms
Number Title Description Comments
1 Fructose
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2 Glucose
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Randomized Controlled Trial (parallel)
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Trial Name nr
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Funding Source Grants from NIH, National Center for Research Resources, the NIH Roadmap for Medical Research, American Diabetes Association, USDA-ARS
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Intervention (Exposure) Information Fructose
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beverage
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25% energy requirement
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10 weeks
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Replacement
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Study Randomization No
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Comparator Information glucose
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25% energy requirement
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Isocaloric
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Baseline Health Status overweight and obese
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Sample Size 32
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Anthropometry at Baseline kg/m2 (mean calculated across groups)
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29.4
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Male % 50
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Country USA
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Age ... Value Mean ... 53.8
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Was a power calculation performed? No
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Was the study blinded? Unclear
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What is the study population? Adults
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Publication Year 2009
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Results & Comparisons


Results Data
Outcome: Free fatty acids      Population: All Participants
Time Point Measure Fructose Glucose


10 weeks

N Analyzed
Mean
Standard Deviation
N Analyzed Standard Error P-Value % change
Outcome: Glucose (blood sugar)      Population: All Participants Between-Arm Comparisons
Time Point Measure Fructose Glucose Comparison Measure


10 weeks

N Analyzed 17 15
Mean
Standard Deviation