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Study Title and Description

Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study.



Key Questions Addressed
1 What is the effect of sugars on health outcomes in intervention studies?
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Primary Publication Information
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TitleData
Title Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study.
Author Vos MB., Weber MB., Welsh J., Khatoon F., Jones DP., Whitington PF., McClain CJ.
Country Department of Pediatrics, Emory University School of Medicine, 164 Ridley Circle, Decatur, GA 30030, USA. mvos@emory.edu
Year 2009
Numbers Pubmed ID: 19581556
214 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Sugar Evidence Map Intervention Studies
Arms
Number Title Description Comments
1 Fructose
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2 fat
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Randomized Controlled Trial (parallel)
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Trial Name nr
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Funding Source American College of Gastroenterology, Ruth L. Kirschstein National Research Service Award and National Institute of Child Health and Human Development
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Intervention (Exposure) Information Fructose
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in diet
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low fructose
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6 months
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Replacement
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Study Randomization No
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Comparator Information fat
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low fat
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Unclear
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Baseline Health Status nonalcoholic fatty liver disease
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Sample Size 10
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Anthropometry at Baseline 2.0;2.3
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Male % nr
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Country USA
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Age ... Value Mean ... 12.9
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Was a power calculation performed? No
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Was the study blinded? Unclear
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What is the study population? Children
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Publication Year 2009
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Results & Comparisons


Results Data
Outcome: Blood Pressure      Population: All Participants
Time Point Measure Fructose fat


6 months

Mean 112.3 127.5
Standard Error 5.8 4.3
Outcome: HDL      Population: All Participants
Time Point Measure Fructose fat


6 months

Mean 37.5 46
Standard Error 3 1.7
Outcome: LDL      Population: All Participants
Time Point Measure Fructose fat


6 months

Mean 115 92.8
Standard Error 13 5
Outcome: Total Cholesterol      Population: All Participants
Time Point Measure Fructose fat


6 months

Mean 176.3 160.5
Standard Error 14.7 11.3
Outcome: Triglycerides      Population: All Participants
Time Point Measure Fructose fat


6 months

Mean 119.8 108
Standard Error 20.4 25.5
Outcome: Blood Pressure      Population: All Participants
Time Point Measure Fructose fat


6 months

Mean 67 64.8
Standard Error 3.7 6.4