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Study Title and Description

Children with NAFLD are more sensitive to the adverse metabolic effects of fructose beverages than children without NAFLD.



Key Questions Addressed
1 What is the effect of sugars on health outcomes in intervention studies?
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Primary Publication Information
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TitleData
Title Children with NAFLD are more sensitive to the adverse metabolic effects of fructose beverages than children without NAFLD.
Author Jin R., Le NA., Liu S., Farkas Epperson M., Ziegler TR., Welsh JA., Jones DP., McClain CJ., Vos MB.
Country Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Year 2012
Numbers Pubmed ID: 22544914
20043463 (internal)

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Sugar Evidence Map Intervention Studies
Arms
Number Title Description Comments
1 Fructose
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2 Glucose
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Randomized Controlled Trial (crossover)
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Trial Name nr
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Funding Source Obesity Society Award; NIH grants
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Intervention (Exposure) Information Fructose
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granulated fructose dissolved in water
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nr
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one visit. in ward for 2 days
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Supplement
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Study Randomization No
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Yes
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Was there a washout period between interventions? ... Length of Washout Yes ... 5-14 days
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Comparator Information glucose as dextrose in water
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nd
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Isocaloric
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Baseline Health Status half healthy half with NAFLD
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Sample Size 19
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Anthropometry at Baseline Non-NAFLD, NAFLD (SE)
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1.0 (0.3), 2.2 (0.1)
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Male % 89
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Country United States
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Age ... Value Mean ... Non-NAFLD=13.8; NAFLD=13.6
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Standard Error ... Non-NAFLD=0.7; NAFLD=0.9
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Was a power calculation performed? Yes
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Was the study blinded? Yes
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Yes
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No
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Yes
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What is the study population? Children
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Publication Year 2012
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Results & Comparisons

No Results found.