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Study Title and Description

Effects of ingested fructose and infused glucagon on endogenous glucose production in obese NIDDM patients, obese non-diabetic subjects, and healthy subjects.



Key Questions Addressed
1 What is the effect of sugars on health outcomes in intervention studies?
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Primary Publication Information
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TitleData
Title Effects of ingested fructose and infused glucagon on endogenous glucose production in obese NIDDM patients, obese non-diabetic subjects, and healthy subjects.
Author Paquot N., Schneiter P., Jéquier E., Gaillard R., Lefèbvre PJ., Scheen A., Tappy L.
Country Départment of Médecine, CHU Sart Tilman, Liège, Belgium.
Year 1996
Numbers Pubmed ID: 8739918

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Sugar Evidence Map Intervention Studies
Arms
Number Title Description Comments
1 Fructose Protocol 1: 300 mg/kg FFM, dissolved in 50 ml lemon-flavoured water
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2 Glucagon + Fructose Protocol 2: 300 mg/kg FFM, dissolved in 50 ml lemon-flavoured water + glucagon was infused at a rate of 3 ng. kg- I 9r ain- 1 between 0 and 180 min
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3 Choose a suggested Arm... Protocol 3: glucagon infused at a rate of 3 ng. kg- I 9r ain- 1 between 0 and 180 min
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Design Details
Question... Follow Up Answer Follow-up Answer
Study Design Single-arm Trial
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Trial Name nr
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Funding Source grants fromthe Swiss National Science Foundation, the BelgianFonds de la Recherche Scientifique M6dicale, the Foundationof Professor Dr. Max Clo6tta and the Foundation Raymond Berger.
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Intervention (Exposure) Information Fructose
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Fructose plus glucagon
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glucagon
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dissolved in 50 ml lemon-flavoured water
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fructose dissolved in 50 ml lemon-flavoured water plus glucose constant diffusion for 180 min
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constant infusion for 180 min
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300 mg/kg
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300 mg/kg fructose + 3 ng. kg- I
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3 ng - kg 1. min-1 between 0 and 180 min
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180 min
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180 min
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180 min
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Replacement
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Replacement
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Replacement
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Study Randomization No
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No
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Was there a washout period between interventions? Not Reported
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Baseline Health Status obese non-insulin-dependent diabetics, obese non-diabetics, lean healthy
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Sample Size 23
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Anthropometry at Baseline lean healthy; obese non-insulin-dependent diabetics; obese non-diabetics
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kg: lean healthy; obese non-insulin-dependent diabetics; obese non-diabetics
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71.7, 88.2, 92.8
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Male % 35
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Country Switzerland
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Age ... Value Mean ... lean healthy: 23.1, obese non-insulin-dependent diabetics:55.5, obese non-diabetics: 41.1
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Was a power calculation performed? No
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Was the study blinded? No
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No
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No
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No
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What is the study population? Adults
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Publication Year 1996
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Results & Comparisons

No Results found.