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Project: Intermittent Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists for Asthma

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Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Extraction Form Diana Sobieraj 1, 2, 3, 4, 5, 6


Associated Studies (each link opens a new tab)

Title Author Year
Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. Bacharier LB., Phillips BR., Zeiger RS., Szefler SJ., Martinez FD., Lemanske RF., Sorkness CA., Bloomberg GR., Morgan WJ., Paul IM., Guilbert T., Krawiec M., Covar R., Larsen G., Mellon M., Moss MH., Chinchilli VM., Taussig LM., Strunk RC. 2008
Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. Ducharme FM., Lemire C., Noya FJ., Davis GM., Alos N., Leblond H., Savdie C., Collet JP., Khomenko L., Rivard G., Platt RW. 2009
Intermittent treatment with high dose nebulized beclomethasone for recurrent wheezing in infants due to upper respiratory tract infection. Ghirga G., Ghirga P., Fagioli S., Colaiacomo M. 2002
Regular vs prn nebulized treatment in wheeze preschool children. Papi A., Nicolini G., Baraldi E., Boner AL., Cutrera R., Rossi GA., Fabbri LM. 2009
Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Svedmyr J., Nyberg E., Thunqvist P., Asbrink-Nilsson E., Hedlin G. 1999
Daily or intermittent budesonide in preschool children with recurrent wheezing. Zeiger RS., Mauger D., Bacharier LB., Guilbert TW., Martinez FD., Lemanske RF., Strunk RC., Covar R., Szefler SJ., Boehmer S., Jackson DJ., Sorkness CA., Gern JE., Kelly HW., Friedman NJ., Mellon MH., Schatz M., Morgan WJ., Chinchilli VM., Raissy HH., Bade E., Malka-Rais J., Beigelman A., Taussig LM. 2011
Daily versus as-needed corticosteroids for mild persistent asthma. Boushey HA., Sorkness CA., King TS., Sullivan SD., Fahy JV., Lazarus SC., Chinchilli VM., Craig TJ., Dimango EA., Deykin A., Fagan JK., Fish JE., Ford JG., Kraft M., Lemanske RF., Leone FT., Martin RJ., Mauger EA., Pesola GR., Peters SP., Rollings NJ., Szefler SJ., Wechsler ME., Israel E. 2005
Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. Calhoun WJ., Ameredes BT., King TS., Icitovic N., Bleecker ER., Castro M., Cherniack RM., Chinchilli VM., Craig T., Denlinger L., DiMango EA., Engle LL., Fahy JV., Grant JA., Israel E., Jarjour N., Kazani SD., Kraft M., Kunselman SJ., Lazarus SC., Lemanske RF., Lugogo N., Martin RJ., Meyers DA., Moore WC., Pascual R., Peters SP., Ramsdell J., Sorkness CA., Sutherland ER., Szefler SJ., Wasserman SI., Walter MJ., Wechsler ME., Boushey HA. 2012
Poor adherence to self-medication instructions in children with asthma and their parents. Colland VT., van Essen-Zandvliet LE., Lans C., Denteneer A., Westers P., Brackel HJ. 2004
Doubling the dose of budesonide versus maintenance treatment in asthma exacerbations. FitzGerald JM., Becker A., Sears MR., Mink S., Chung K., Lee J. 2004
Low-dose budesonide with the addition of an increased dose during exacerbations is effective in long-term asthma control. On behalf of the Italian Study Group. Foresi A., Morelli MC., Catena E. 2000
Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma. Gerald JK., Gerald LB., Vasquez MM., Morgan WJ., Boehmer SJ., Lemanske RF., Mauger DT., Strunk RC., Szefler SJ., Zeiger RS., Bacharier LB., Bade E., Covar RA., Guilbert TW., Heidarian-Raissy H., Kelly HW., Malka-Rais J., Sorkness CA., Taussig LM., Chinchilli VM., Martinez FD. -- Not Found --
Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Harrison TW., Oborne J., Newton S., Tattersfield AE. 2004
Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Martinez FD., Chinchilli VM., Morgan WJ., Boehmer SJ., Lemanske RF., Mauger DT., Strunk RC., Szefler SJ., Zeiger RS., Bacharier LB., Bade E., Covar RA., Friedman NJ., Guilbert TW., Heidarian-Raissy H., Kelly HW., Malka-Rais J., Mellon MH., Sorkness CA., Taussig L. 2011
Quadrupling the dose of inhaled corticosteroid to prevent asthma exacerbations: a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Oborne J., Mortimer K., Hubbard RB., Tattersfield AE., Harrison TW. 2009
Rescue use of beclomethasone and albuterol in a single inhaler for mild asthma. Papi A., Canonica GW., Maestrelli P., Paggiaro P., Olivieri D., Pozzi E., Crimi N., Vignola AM., Morelli P., Nicolini G., Fabbri LM. 2007
Daily versus as-needed inhaled corticosteroid for mild persistent asthma (The Helsinki early intervention childhood asthma study). Turpeinen M., Nikander K., Pelkonen AS., Syvänen P., Sorva R., Raitio H., Malmberg P., Juntunen-Backman K., Haahtela T. 2008
Randomised comparison of guided self management and traditional treatment of asthma over one year. Lahdensuo A., Haahtela T., Herrala J., Kava T., Kiviranta K., Kuusisto P., Perämäki E., Poussa T., Saarelainen S., Svahn T. 1996
Effect of β2-adrenergic receptor gene (ADRB2) 3' untranslated region polymorphisms on inhaled corticosteroid/long-acting β2-adrenergic agonist response. Ambrose HJ., Lawrance RM., Cresswell CJ., Goldman M., Meyers DA., Bleecker ER. 2012
Budesonide/formoterol maintenance and reliever therapy via Turbuhaler versus fixed-dose budesonide/formoterol plus terbutaline in patients with asthma: phase III study results. Atienza T., Aquino T., Fernández M., Boonsawat W., Kawai M., Kudo T., Ekelund J., Ivanov S., Carlsson LG. 2013
Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. Bateman ED., Harrison TW., Quirce S., Reddel HK., Buhl R., Humbert M., Jenkins CR., Peterson S., Ostlund O., O'Byrne PM., Sears MR., Eriksson GS. 2011
Overall asthma control: the relationship between current control and future risk. Bateman ED., Reddel HK., Eriksson G., Peterson S., Ostlund O., Sears MR., Jenkins C., Humbert M., Buhl R., Harrison TW., Quirce S., O'Byrne PM. 2010
Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma. Bisgaard H., Le Roux P., Bjåmer D., Dymek A., Vermeulen JH., Hultquist C. 2006
Budesonide/formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasone. Bousquet J., Boulet LP., Peters MJ., Magnussen H., Quiralte J., Martinez-Aguilar NE., Carlsheimer A. 2007
The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard therapy. Buhl R., Kuna P., Peters MJ., Andersson TL., Naya IP., Peterson S., Rabe KF. 2012
Comparison of the effects of budesonide/formoterol maintenance and reliever therapy with fluticasone/salmeterol fixed-dose treatment on airway inflammation and small airway impairment in patients who need to step-up from inhaled corticosteroid monotherapy. Hozawa S., Terada M., Hozawa M. 2014
Budesonide/formoterol maintenance and reliever therapy versus free-combination therapy for asthma: a real-life study. Kardos P. 2013
Treatment comparison of budesonide/formoterol with salmeterol/fluticasone propionate in adults aged > or =16 years with asthma: post hoc analysis of a randomized, double-blind study. Kuna P. 2010
Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations. Kuna P., Peters MJ., Manjra AI., Jorup C., Naya IP., Martínez-Jimenez NE., Buhl R. 2007
A comparison of budesonide/formoterol maintenance and reliever therapy vs. conventional best practice in asthma management. Louis R., Joos G., Michils A., Vandenhoven G. 2009
Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. O'Byrne PM., Bisgaard H., Godard PP., Pistolesi M., Palmqvist M., Zhu Y., Ekström T., Bateman ED. 2005
Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial. Papi A., Corradi M., Pigeon-Francisco C., Baronio R., Siergiejko Z., Petruzzelli S., Fabbri LM., Rabe KF. 2013
The use of β2-agonist therapy before hospital attendance for severe asthma exacerbations: a post-hoc analysis. Patel M., Pilcher J., Hancox RJ., Sheahan D., Pritchard A., Braithwaite I., Shaw D., Black P., Weatherall M., Beasley R. 2015
Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial. Patel M., Pilcher J., Pritchard A., Perrin K., Travers J., Shaw D., Holt S., Harwood M., Black P., Weatherall M., Beasley R. 2013
Predictors of severe exacerbations, poor asthma control, and β-agonist overuse for patients with asthma. Patel M., Pilcher J., Reddel HK., Qi V., Mackey B., Tranquilino T., Shaw D., Black P., Weatherall M., Beasley R. -- Not Found --
Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol. Pavord ID., Jeffery PK., Qiu Y., Zhu J., Parker D., Carlsheimer A., Naya I., Barnes NC. 2009
Combination budesonide/formoterol inhaler as maintenance and reliever therapy in Māori with asthma. Pilcher J., Patel M., Smith A., Davies C., Pritchard A., Travers J., Black P., Weatherall M., Beasley R., Harwood M. 2014
A comparison of budesonide/formoterol maintenance and reliever therapy versus conventional best practice in asthma management in Spain. Quirce S., Barcina C., Plaza V., Calvo E., Muñoz M., Ampudia R., Capel M. 2011
Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Rabe KF., Atienza T., Magyar P., Larsson P., Jorup C., Lalloo UG. 2006
Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Rabe KF., Pizzichini E., Ställberg B., Romero S., Balanzat AM., Atienza T., Lier PA., Jorup C. 2006
Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol. Pavord ID., Jeffery PK., Qiu Y., Zhu J., Parker D., Carlsheimer A., Naya I., Barnes NC. 2009
Combination budesonide/formoterol inhaler as maintenance and reliever therapy in Māori with asthma. Pilcher J., Patel M., Smith A., Davies C., Pritchard A., Travers J., Black P., Weatherall M., Beasley R., Harwood M. 2014
A comparison of budesonide/formoterol maintenance and reliever therapy versus conventional best practice in asthma management in Spain. Quirce S., Barcina C., Plaza V., Calvo E., Muñoz M., Ampudia R., Capel M. 2011
Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Rabe KF., Atienza T., Magyar P., Larsson P., Jorup C., Lalloo UG. 2006
Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Rabe KF., Pizzichini E., Ställberg B., Romero S., Balanzat AM., Atienza T., Lier PA., Jorup C. 2006
Budesonide/formoterol maintenance and reliever therapy in primary care asthma management: effects on bronchial hyperresponsiveness and asthma control. Riemersma RA., Postma D., van der Molen T. 2012
Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Scicchitano R., Aalbers R., Ukena D., Manjra A., Fouquert L., Centanni S., Boulet LP., Naya IP., Hultquist C. 2004
Budesonide/formoterol maintenance and reliever therapy: impact on airway inflammation in asthma. Sears MR., Boulet LP., Laviolette M., Fitzgerald JM., Bai TR., Kaplan A., Smiljanic-Georgijev N., Lee JS. 2008
Budesonide/formoterol maintenance and reliever therapy versus conventional best standard treatment in asthma in an attempted 'real life' setting. Søes-Petersen U., Kava T., Dahle R., Lei Y., Dam N. 2011
Poor adherence with inhaled corticosteroids for asthma: can using a single inhaler containing budesonide and formoterol help? Sovani MP., Whale CI., Oborne J., Cooper S., Mortimer K., Ekström T., Tattersfield AE., Harrison TW. 2008
A real-life cost-effectiveness evaluation of budesonide/formoterol maintenance and reliever therapy in asthma. Ställberg B., Ekström T., Neij F., Olsson P., Skoogh BE., Wennergren G., Löfdahl CG. 2008
Budesonide/formoterol maintenance and reliever therapy in moderate-to-severe asthma: effects on eosinophilic airway inflammation. Takeyama K., Kondo M., Tagaya E., Kirishi S., Ishii M., Ochiai K., Isono K., Tamaoki J. -- Not Found --
Budesonide/formoterol maintenance and reliever therapy: an effective asthma treatment option? Vogelmeier C., D'Urzo A., Pauwels R., Merino JM., Jaspal M., Boutet S., Naya I., Price D. 2005
Budesonide/formoterol maintenance and reliever therapy in Asian patients (aged ≥16 years) with asthma: a sub-analysis of the COSMOS study. Vogelmeier C., Naya I., Ekelund J. 2012
Budesonide/formoterol maintenance and reliever therapy in Chinese patients with asthma. Lin JT., Chen P., Zhou X., Sun TY., Xie CM., Xiu QY., Yao WZ., Yang L., Yin KS., Zhang YM. 2012
Budesonide/formoterol combination therapy as both maintenance and reliever medication in moderate-to-severe asthma: a real-life effectiveness study of Malaysian patients. Loh LC., Lim BK., Raman S., Vijayasingham P., Mohd Yusuf S. 2008
Maintenance plus reliever budesonide/formoterol compared with a higher maintenance dose of budesonide/formoterol plus formoterol as reliever in asthma: an efficacy and cost-effectiveness study. Lundborg M., Wille S., Bjermer L., Tilling B., Lundgren M., Telg G., Ekström T., Selroos O. 2006
Effect of smoking status on the efficacy of the SMART regimen in high risk asthma. Pilcher J., Patel M., Reddel HK., Pritchard A., Black P., Shaw D., Holt S., Weatherall M., Beasley R. 2016
Comparison of early effects of budesonide/formoterol maintenance and reliever therapy with fluticasone furoate/vilanterol for asthma patients requiring step-up from inhaled corticosteroid monotherapy. Hozawa S., Terada M., Haruta Y., Hozawa M. 2016
Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status. Kerstjens HA., Moroni-Zentgraf P., Tashkin DP., Dahl R., Paggiaro P., Vandewalker M., Schmidt H., Engel M., Bateman ED. 2016
Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study. Rajanandh MG., Nageswari AD., Ilango K. 2014
Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial. Rajanandh MG., Nageswari AD., Ilango K. 2015
Anticholinergic vs Long-Acting β-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial. Wechsler ME., Yawn BP., Fuhlbrigge AL., Pace WD., Pencina MJ., Doros G., Kazani S., Raby BA., Lanzillotti J., Madison S., Israel E. 2015
Assessment of various second-line medications in addition to inhaled corticosteroid in asthma patients: a randomized controlled trial. Rajanandh MG., Nageswari AD., Ilango K. 2014
Tiotropium in asthma poorly controlled with standard combination therapy. Kerstjens HA., Engel M., Dahl R., Paggiaro P., Beck E., Vandewalker M., Sigmund R., Seibold W., Moroni-Zentgraf P., Bateman ED. 2012
Assessment of second-line treatments for patients with uncontrolled moderate asthma. Wang K., Tian P., Fan Y., Wang Y., Liu C. 2015
A randomised controlled trial of tiotropium in adolescents with severe symptomatic asthma. Hamelmann E., Bernstein JA., Vandewalker M., Moroni-Zentgraf P., Verri D., Unseld A., Engel M., Boner AL. 2017
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. Peters SP., Kunselman SJ., Icitovic N., Moore WC., Pascual R., Ameredes BT., Boushey HA., Calhoun WJ., Castro M., Cherniack RM., Craig T., Denlinger L., Engle LL., DiMango EA., Fahy JV., Israel E., Jarjour N., Kazani SD., Kraft M., Lazarus SC., Lemanske RF., Lugogo N., Martin RJ., Meyers DA., Ramsdell J., Sorkness CA., Sutherland ER., Szefler SJ., Wasserman SI., Walter MJ., Wechsler ME., Chinchilli VM., Bleecker ER. 2010
Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma. Bateman ED., Kornmann O., Schmidt P., Pivovarova A., Engel M., Fabbri LM. 2011
Hippocampal synaptic transmission: regulation of the NMDA receptor-mediated component. Herron CE., Forsythe ID. 1989
The effect of fluticasone furoate/umeclidinium in adult patients with asthma: a randomized, dose-ranging study. Lee LA., Yang S., Kerwin E., Trivedi R., Edwards LD., Pascoe S. 2015
Long-Term Once-Daily Tiotropium Respimat® Is Well Tolerated and Maintains Efficacy over 52 Weeks in Patients with Symptomatic Asthma in Japan: A Randomised, Placebo-Controlled Study. Ohta K., Ichinose M., Tohda Y., Engel M., Moroni-Zentgraf P., Kunimitsu S., Sakamoto W., Adachi M. 2015
The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial. Paggiaro P., Halpin DM., Buhl R., Engel M., Zubek VB., Blahova Z., Moroni-Zentgraf P., Pizzichini E. -- Not Found --
Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial. Hamelmann E., Bateman ED., Vogelberg C., Szefler SJ., Vandewalker M., Moroni-Zentgraf P., Avis M., Unseld A., Engel M., Boner AL. 2016




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