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Project: Comparative Effectiveness of Analgesics to Reduce Acute Pain in the Prehospital Setting

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Key Questions


Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Extraction Form Diana Sobieraj 1, 2, 3, 4


Associated Studies (each link opens a new tab)

Title Author Year
Nebulized fentanyl vs intravenous morphine for ED patients with acute abdominal pain: a randomized double-blinded, placebo-controlled clinical trial. Deaton T., Auten JD., Darracq MA. 2015
Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial. Farahmand S., Shiralizadeh S., Talebian MT., Bagheri-Hariri S., Arbab M., Basirghafouri H., Saeedi M., Sedaghat M., Mirzababai H. 2014
Nebulized fentanyl versus intravenous morphine in children with suspected limb fractures in the emergency department: a randomized controlled trial. Furyk JS., Grabowski WJ., Black LH. 2009
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. Galinski M., Dolveck F., Combes X., Limoges V., Smaïl N., Pommier V., Templier F., Catineau J., Lapostolle F., Adnet F. 2007
Nebulized fentanyl vs intravenous morphine for ED patients with acute abdominal pain: a randomized double-blinded, placebo-controlled clinical trial. Deaton T., Auten JD., Darracq MA. 2015
Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial. Farahmand S., Shiralizadeh S., Talebian MT., Bagheri-Hariri S., Arbab M., Basirghafouri H., Saeedi M., Sedaghat M., Mirzababai H. 2014
Nebulized fentanyl versus intravenous morphine in children with suspected limb fractures in the emergency department: a randomized controlled trial. Furyk JS., Grabowski WJ., Black LH. 2009
Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. Galinski M., Dolveck F., Combes X., Limoges V., Smaïl N., Pommier V., Templier F., Catineau J., Lapostolle F., Adnet F. 2007
A comparison of ketamine and morphine analgesia in prehospital trauma care: a cluster randomized clinical trial in rural Quang Tri province, Vietnam. Tran KP., Nguyen Q., Truong XN., Le V., Le VP., Mai N., Husum H., Losvik OK. -- Not Found --
Analgesic Efficacy of Intranasal Ketamine Versus Intranasal Fentanyl for Moderate to Severe Pain in Children: A Prospective, Randomized, Double-Blind Study. Quinn K., Kriss S., Drapkin J., Likourezos A., Pushkar I., Brady J., Yasavolian M., Chitnis SS., Motov S., Fromm C. 2018
Project for the introduction of prehospital analgesia with fentanyl and morphine administered by specially trained paramedics in a rural service area in Germany. Scharonow M., Alberding T., Oltmanns W., Weilbach C. 2017
Impact of age, sex and route of administration on adverse events after opioid treatment in the emergency department: a retrospective study. Daoust R., Paquet J., Lavigne G., Piette É., Chauny JM. -- Not Found --
Expedited Delivery of Pain Medication for Long-Bone Fractures Using an Intranasal Fentanyl Clinical Pathway. Schacherer NM., Erikson Ramirez D., Frazier SB., Perkins AM. 2015
Morphine versus fentanyl for pain due to traumatic injury in the emergency department. Wenderoth BR., Kaneda ET., Amini A., Amini R., Patanwala AE. -- Not Found --
Effectiveness of prehospital morphine, fentanyl, and methoxyflurane in pediatric patients. Bendall JC., Simpson PM., Middleton PM. -- Not Found --
Analysis of the paramedic administration of fentanyl. Garrick JF., Kidane S., Pointer JE., Sugiyama W., Van Luen C., Clark R. -- Not Found --
Effectiveness and safety of fentanyl compared with morphine for out-of-hospital analgesia. Fleischman RJ., Frazer DG., Daya M., Jui J., Newgard CD. -- Not Found --
Not Entered Yet - -
Intravenous paracetamol vs ibuprofen in renal colic: a randomised, double-blind, controlled clinical trial. Cenker E., Serinken M., Uyanık E. 2018
Administering analgesia sublingually is a suitable option for children with acute abdominal pain in the emergency department. Cozzi G., Zanchi C., Chiaretti A., Tipo V., Cernich M., D'Anna C., Fantacci C., Conversano E., Zanon D., Ronfani L., Barbi E. 2019
Comparison of Fentanyl and Morphine in the Prehospital Treatment of Ischemic Type Chest Pain. Weldon ER., Ariano RE., Grierson RA. 2016
The effectiveness and adverse events of morphine versus fentanyl on a physician-staffed helicopter. Smith MD., Wang Y., Cudnik M., Smith DA., Pakiela J., Emerman CL. 2012
A randomized controlled trial of intranasal fentanyl vs intravenous morphine for analgesia in the prehospital setting. Rickard C., O'Meara P., McGrail M., Garner D., McLean A., Le Lievre P. 2007
A randomized, double-blind study comparing morphine with fentanyl in prehospital analgesia. Galinski M., Dolveck F., Borron SW., Tual L., Van Laer V., Lardeur JY., Lapostolle F., Adnet F. 2005
Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial. Farahmand S., Shiralizadeh S., Talebian MT., Bagheri-Hariri S., Arbab M., Basirghafouri H., Saeedi M., Sedaghat M., Mirzababai H. 2014
A randomized clinical trial of oral transmucosal fentanyl citrate versus intravenous morphine sulfate for initial control of pain in children with extremity injuries. Mahar PJ., Rana JA., Kennedy CS., Christopher NC. 2007
A randomized controlled trial comparing intranasal fentanyl to intravenous morphine for managing acute pain in children in the emergency department. Borland M., Jacobs I., King B., O'Brien D. 2007
Comparison of clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic: a randomized, double-blind, controlled trial. Masoumi K., Forouzan A., Asgari Darian A., Feli M., Barzegari H., Khavanin A. 2014
Effect of Intravenous Morphine and Ketorolac on Pain Control in Long Bones Fractures. Masoumi B., Farzaneh B., Ahmadi O., Heidari F. 2017
Intravenous morphine plus ketorolac is superior to either drug alone for treatment of acute renal colic. Safdar B., Degutis LC., Landry K., Vedere SR., Moscovitz HC., D'Onofrio G. 2006
Oral Analgesics Utilization for Children With Musculoskeletal Injury (OUCH Trial): An RCT. Le May S., Ali S., Plint AC., Mâsse B., Neto G., Auclair MC., Drendel AL., Ballard A., Khadra C., Villeneuve E., Parent S., McGrath PJ., Leclair G., Gouin S. 2017
Comparison of paracetamol (apotel®) and morphine in reducing post pure head trauma headache. Shams Vahdati S., Morteza Baghi HR., Ghobadi J., Rajaei Ghafouri R., Habibollahi P. 2014
Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial. Pathan SA., Mitra B., Straney LD., Afzal MS., Anjum S., Shukla D., Morley K., Al Hilli SA., Al Rumaihi K., Thomas SH., Cameron PA. 2016
Low-dose intravenous ketamine versus intravenous ketorolac in pain control in patients with acute renal colic in an emergency setting: a double-blind randomized clinical trial. Sotoodehnia M., Farmahini-Farahani M., Safaie A., Rasooli F., Baratloo A. 2019
Comparison of Intravenous Morphine Versus Paracetamol in Sciatica: A Randomized Placebo Controlled Trial. Serinken M., Eken C., Gungor F., Emet M., Al B. 2016
Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial. Eken C., Serinken M., Elicabuk H., Uyanik E., Erdal M. 2014
Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial. Serinken M., Eken C., Turkcuer I., Elicabuk H., Uyanik E., Schultz CH. 2012
Randomised comparison of intravenous paracetamol and intravenous morphine for acute traumatic limb pain in the emergency department. Craig M., Jeavons R., Probert J., Benger J. 2012
Comparison of IV dexketoprofen trometamol, fentanyl, and paracetamol in the treatment of renal colic in the ED: A randomized controlled trial. Al B., Sunar MM., Zengin S., Sabak M., Bogan M., Can B., Kul S., Murat Oktay M., Eren SH. 2018
Comparison of intranasal ketamine versus IV morphine in reducing pain in patients with renal colic. Farnia MR., Jalali A., Vahidi E., Momeni M., Seyedhosseini J., Saeedi M. 2017
Intravenous subdissociative-dose ketamine versus morphine for acute geriatric pain in the Emergency Department: A randomized controlled trial. Motov S., Mann S., Drapkin J., Butt M., Likourezos A., Yetter E., Brady J., Rothberger N., Gohel A., Flom P., Mai M., Fromm C., Marshall J. 2019
Acute Pain Management in Emergency Department, Low Dose Ketamine Versus Morphine, A Randomized Clinical Trial. Mahshidfar B., Mofidi M., Fattahi M., Farsi D., Hafezi Moghadam P., Abbasi S., Rezai M. 2017
Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial. Motov S., Rockoff B., Cohen V., Pushkar I., Likourezos A., McKay C., Soleyman-Zomalan E., Homel P., Terentiev V., Fromm C. 2015
Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial. Miller JP., Schauer SG., Ganem VJ., Bebarta VS. 2015
Comparison of Intravenous Ketamine with Morphine in Pain Relief of Long Bones Fractures: a Double Blind Randomized Clinical Trial. Majidinejad S., Esmailian M., Emadi M. 2014
Efficacy and Safety of Morphine and Low Dose Ketamine for Pain Control of Patients with Long Bone Fractures: A Randomized, Double-Blind, Clinical Trial. Jahanian F., Hosseininejad SM., Amini Ahidashti H., Bozorgi F., Goli Khatir I., Montazar SH., Azarfar V. 2018
Intravenous Low-Dose Ketamine Provides Greater Pain Control Compared to Fentanyl in a Civilian Prehospital Trauma System: A Propensity Matched Analysis. Bronsky ES., Koola C., Orlando A., Redmond D., D'Huyvetter C., Sieracki H., Tanner A., Fowler R., Mains C., Bar-Or D. 2018
Multicenter, Prospective Study of Prehospital Administration of Analgesia in the U.S. Combat Theater of Afghanistan. Schauer SG., Mora AG., Maddry JK., Bebarta VS. -- Not Found --
Prehospital pain medication use by U.S. Forces in Afghanistan. Shackelford SA., Fowler M., Schultz K., Summers A., Galvagno SM., Gross KR., Mabry RL., Bailey JA., Kotwal RS., Butler FK. 2015
Morphine and ketamine is superior to morphine alone for out-of-hospital trauma analgesia: a randomized controlled trial. Jennings PA., Cameron P., Bernard S., Walker T., Jolley D., Fitzgerald M., Masci K. 2012
The effect of combined treatment with morphine sulphate and low-dose ketamine in a prehospital setting. Johansson P., Kongstad P., Johansson A. 2009
A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma. Clark E., Plint AC., Correll R., Gaboury I., Passi B. 2007
Factors Influencing Quality of Pain Management in a Physician Staffed Helicopter Emergency Medical Service. Oberholzer N., Kaserer A., Albrecht R., Seifert B., Tissi M., Spahn DR., Maurer K., Stein P. 2017
Comparing the analgesic efficacy of morphine plus ketamine versus morphine plus placebo in patients with acute renal colic: A double-blinded randomized controlled trial. Hosseininejad SM., Jahanian F., Erfanian Irankar S., Moosazadeh M., Hosseini SA., Shahbakhti N., Bozorgi F. 2019
The Use of Ketamine for Acute Treatment of Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Sin B., Tatunchak T., Paryavi M., Olivo M., Mian U., Ruiz J., Shah B., de Souza S. 2017
Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial. Beaudoin FL., Lin C., Guan W., Merchant RC. 2014
Can low-dose of ketamine reduce the need for morphine in renal colic? A double-blind randomized clinical trial. Abbasi S., Bidi N., Mahshidfar B., Hafezimoghadam P., Rezai M., Mofidi M., Farsi D. 2018
Effect of Intranasal Ketamine vs Fentanyl on Pain Reduction for Extremity Injuries in Children: The PRIME Randomized Clinical Trial. Frey TM., Florin TA., Caruso M., Zhang N., Zhang Y., Mittiga MR. 2019
Randomized Controlled Feasibility Trial of Intranasal Ketamine Compared to Intranasal Fentanyl for Analgesia in Children with Suspected Extremity Fractures. Reynolds SL., Bryant KK., Studnek JR., Hogg M., Dunn C., Templin MA., Moore CG., Young JR., Walker KR., Runyon MS. 2017
The PICHFORK (Pain in Children Fentanyl or Ketamine) trial: a randomized controlled trial comparing intranasal ketamine and fentanyl for the relief of moderate to severe pain in children with limb injuries. Graudins A., Meek R., Egerton-Warburton D., Oakley E., Seith R. 2015
Intranasal ketamine for acute traumatic pain in the Emergency Department: a prospective, randomized clinical trial of efficacy and safety. Shimonovich S., Gigi R., Shapira A., Sarig-Meth T., Nadav D., Rozenek M., West D., Halpern P. 2016
Intranasal ketamine administration for narcotic dose decrement in patients suffering from acute limb trauma in emergency department: a double-blind randomized placebo-controlled trial 1. Mohammadshahi A, Abdolrazaghnejad A, Nikzamir H, Safaie A 2018
Comparing the effect of intravenous acetaminophen (Apotel®) and intravenous morphine in controlling the pain of forearm and leg fractures in adults Mollaei M, Esmailian M, Heydari F. 2016
A prospective randomized pilot comparison of intranasal fentanyl and intramuscular morphine for analgesia in children presenting to the emergency department with clinical fractures Younge PA, Nicol MF, Kendall JM, et al 1999
Sub-dissociative ketamine for the management of acute pediatric pain. https://clinicaltrials.gov/ct2/show/NCT01951963?term=NCT01951963&rank=1
Efficacy of intravenous paracetamol versus intravenous morphine in acute limb trauma Jalili M, Mozaffarpour Noori A, Sedaghat M, Safaie A 2016
Efficacy of nebulized fentanyl and low dose ketamine for pain control of patients with long bone fractures: a randomized, double-blind, clinical trial Verki MM, Mozafari J, Tirandaz F, Motamed H, Khazaeli 2019




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