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Project: Management of Acute Diverticulitis

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Project Summary

Title and Description


Key Questions


Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Extraction Form for KQs 2 and 4 Ian Saldanha 2, 4
KQ 3: Colonoscopy Ethan Balk 3


Associated Studies (each link opens a new tab)

Title Author Year
Randomized clinical trial of antibiotics in acute uncomplicated diverticulitis. Chabok A., Påhlman L., Hjern F., Haapaniemi S., Smedh K. 2012
Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis. Daniels L., Ünlü Ç., de Korte N., van Dieren S., Stockmann HB., Vrouenraets BC., Consten EC., van der Hoeven JA., Eijsbouts QA., Faneyte IF., Bemelman WA., Dijkgraaf MG., Boermeester MA. 2017
Prospective randomized trial comparing short-term antibiotic therapy versus standard therapy for acute uncomplicated sigmoid diverticulitis. Schug-Pass C., Geers P., Hügel O., Lippert H., Köckerling F. 2010
Antibiotics alone instead of percutaneous drainage as initial treatment of large diverticular abscess. XXX - EXCLUDED - Elagili F., Stocchi L., Ozuner G., Kiran RP. 2015
Randomized controlled trial of oral vs intravenous therapy for the clinically diagnosed acute uncomplicated diverticulitis. Ridgway PF., Latif A., Shabbir J., Ofriokuma F., Hurley MJ., Evoy D., O'Mahony JB., Mealy K. 2009
Treatment of acute uncomplicated diverticulitis without antibiotics: risk factors for treatment failure. Bolkenstein HE., Draaisma WA., van de Wall B., Consten E., Broeders I. 2018
Outpatient versus hospitalization management for uncomplicated diverticulitis: a prospective, multicenter randomized clinical trial (DIVER Trial). Biondo S., Golda T., Kreisler E., Espin E., Vallribera F., Oteiza F., Codina-Cazador A., Pujadas M., Flor B. 2014
Conservative Treatment in Diverticulitis Patients with Pericolic Extraluminal Air and the Role of Antibiotic Treatment. XXX_Bolkenstein HE., van Dijk ST., Consten ECJ., Heggelman BGF., Hoeks CMA., Broeders IAMJ., Boermeester MA., Draaisma WA. 2019
Outpatient treatment of uncomplicated acute diverticulitis: Impact on healthcare costs. Lorente L., Cots F., Alonso S., Pascual M., Salvans S., Courtier R., Gil MJ., Grande L., Pera M. 2013
Population-based study of outcomes following an initial acute diverticular abscess. Aquina CT., Becerra AZ., Xu Z., Justiniano CF., Noyes K., Monson JRT., Fleming FJ. 2019
Applicability, safety and efficiency of outpatient treatment in uncomplicated diverticulitis. Moya P., Arroyo A., Pérez-Legaz J., Serrano P., Candela F., Soriano-Irigaray L., Calpena R. 2012
Mild colonic diverticulitis can be treated without antibiotics. A case-control study. de Korte N., Kuyvenhoven JP., van der Peet DL., Felt-Bersma RJ., Cuesta MA., Stockmann HB. 2012
Elective surgery for diverticulitis is associated with high risk of intestinal diversion and hospital readmission in older adults. Lidor AO., Schneider E., Segal J., Yu Q., Feinberg R., Wu AW. 2010
Surgery versus conservative management for recurrent and ongoing left-sided diverticulitis (DIRECT trial): an open-label, multicentre, randomised controlled trial. van de Wall BJM., Stam MAW., Draaisma WA., Stellato R., Bemelman WA., Boermeester MA., Broeders IAMJ., Belgers EJ., Toorenvliet BR., Prins HA., Consten ECJ. 2017
National Trends in Short-term Outcomes Following Non-emergent Surgery for Diverticular Disease. Papageorge CM., Kennedy GD., Carchman EH. 2016
Outcomes of laparoscopic versus open colectomy in elective surgery for diverticulitis. Masoomi H., Buchberg B., Nguyen B., Tung V., Stamos MJ., Mills S. 2011
A comparison of outcomes of emergent, urgent, and elective surgical treatment of diverticulitis. Moghadamyeghaneh Z., Carmichael JC., Smith BR., Mills S., Pigazzi A., Nguyen NT., Stamos MJ. 2015
Are there differences in outcome after elective sigmoidectomy for diverticular disease and for cancer? A national inpatient study. Ilyas MI., Zangbar B., Nfonsam VN., Maegawa FA., Joseph BA., Patel JA., Wexner SD. 2017
Laparoscopy improves short-term outcomes after surgery for diverticular disease. Russ AJ., Obma KL., Rajamanickam V., Wan Y., Heise CP., Foley EF., Harms B., Kennedy GD. 2010
Mesalamine did not prevent recurrent diverticulitis in phase 3 controlled trials.-A Raskin JB., Kamm MA., Jamal MM., Márquez J., Melzer E., Schoen RE., Szalóki T., Barrett K., Streck P. 2014
Antibiotic treatment for uncomplicated and mild complicated diverticulitis: outpatient treatment for everyone. Joliat GR., Emery J., Demartines N., Hübner M., Yersin B., Hahnloser D. 2017
Surgery After an Initial Episode of Uncomplicated Diverticulitis: Does Time to Resection Matter? Varma S., Mehta A., Canner JK., Azar F., Efron DT., Efron J., Safar B., Sakran JV. 2019
The impact of delaying elective resection of diverticulitis on laparoscopic conversion rate. Simianu V, Sinanan M, Bastawrous A, Billingham R, Fichera A, Florence M, Herzig D, Johnson E, Steele S, Thirlby R, Flum D 2015
Do the risks of emergent colectomy justify nonoperative management strategies for recurrent diverticulitis? Novitsky YW., Sechrist C., Payton BL., Kercher KW., Heniford BT. 2009
Outpatient treatment for acute uncomplicated diverticulitis. Ünlü Ç., Gunadi PM., Gerhards MF., Boermeester MA., Vrouenraets BC. 2013
Diverticulitis Diagnosed in the Emergency Room: Is It Safe to Discharge Home? Sirany AE., Gaertner WB., Madoff RD., Kwaan MR. 2017
A randomized double-blind placebo-controlled trial of a multi-strain probiotic in treatment of symptomatic uncomplicated diverticular disease.-B Kvasnovsky CL., Bjarnason I., Donaldson AN., Sherwood RA., Papagrigoriadis S. 2017
Mesalamine did not prevent recurrent diverticulitis in phase 3 controlled trials. -B(PREVENT2) Raskin JB., Kamm MA., Jamal MM., Márquez J., Melzer E., Schoen RE., Szalóki T., Barrett K., Streck P. 2014
Effects of Burdock tea on recurrence of colonic diverticulitis and diverticular bleeding: An open-labelled randomized clinical trial. Mizuki A., Tatemichi M., Nakazawa A., Tsukada N., Nagata H., Kinoshita Y. 2019
Risk factors for mortality and morbidity after elective sigmoid resection for diverticulitis: prospective multicenter multivariate analysis of 582 patients. Pessaux P., Muscari F., Ouellet JF., Msika S., Hay JM., Millat B., Fingerhut A., Flamant Y. 2004
Laparoscopic sigmoid colectomy for complicated diverticulitis is safe: review of 576 consecutive colectomies. Bhakta A., Tafen M., Glotzer O., Canete J., Chismark AD., Valerian BT., Stain SC., Lee EC. 2016
Multicentre study of non-surgical management of diverticulitis with abscess formation. Lambrichts DPV., Bolkenstein HE., van der Does DCHE., Dieleman D., Crolla RMPH., Dekker JWT., van Duijvendijk P., Gerhards MF., Nienhuijs SW., Menon AG., de Graaf EJR., Consten ECJ., Draaisma WA., Broeders IAMJ., Bemelman WA., Lange JF. 2019
Laparoscopic "fast-track" sigmoidectomy for diverticulitis disease in Germany. Results of a prospective quality assurance program. Tsilimparis N., Haase O., Wendling P., Kipfmüller K., Schmid M., Engemann R., Schwenk W. 2010
Uncomplicated diverticulitis, more complicated than we thought. XXXBoostrom SY., Wolff BG., Cima RR., Merchea A., Dozois EJ., Larson DW. 2012
Prospective randomized clinical trial assessing the efficacy of a short course of intravenously administered amoxicillin plus clavulanic acid followed by oral antibiotic in patients with uncomplicated acute diverticulitis. Ribas Y., Bombardó J., Aguilar F., Jovell E., Alcantara-Moral M., Campillo F., Lleonart X., Serra-Aracil X. 2010
One-day versus four-day antibiotic treatment for acute right colonic uncomplicated diverticulitis: A randomized clinical trial. Park JH., Park HC., Lee BH. 2019
Prospective randomized clinical trial of uncomplicated right-sided colonic diverticulitis: antibiotics versus no antibiotics. Kim JY., Park SG., Kang HJ., Lim YA., Pak KH., Yoo T., Cho WT., Shin DW., Kim JW. 2019
Conservative treatment of acute colonic diverticulitis: are antibiotics always mandatory? Hjern F., Josephson T., Altman D., Holmström B., Mellgren A., Pollack J., Johansson C. 2007
Randomized, prospective comparison of cefoxitin and gentamicin-clindamycin in the treatment of acute colonic diverticulitis. Kellum JM., Sugerman HJ., Coppa GF., Way LR., Fine R., Herz B., Speck EL., Jackson D., Duma RJ. -- Not Found --
Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence. -A Kruis W., Kardalinos V., Eisenbach T., Lukas M., Vich T., Bunganic I., Pokrotnieks J., Derova J., Kondrackiene J., Safadi R., Tuculanu D., Tulassay Z., Banai J., Curtin A., Dorofeyev AE., Zakko SF., Ferreira N., Björck S., Diez Alonso MM., Mäkelä J., Talley NJ., Dilger K., Greinwald R., Mohrbacher R., Spiller R. 2017
Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence. -B Kruis W., Kardalinos V., Eisenbach T., Lukas M., Vich T., Bunganic I., Pokrotnieks J., Derova J., Kondrackiene J., Safadi R., Tuculanu D., Tulassay Z., Banai J., Curtin A., Dorofeyev AE., Zakko SF., Ferreira N., Björck S., Diez Alonso MM., Mäkelä J., Talley NJ., Dilger K., Greinwald R., Mohrbacher R., Spiller R. 2017
Specific Factors Predict the Risk for Urgent and Emergent Colectomy in Patients Undergoing Surgery for Diverticulitis. Valizadeh N., Suradkar K., Kiran RP. 2018
Intermittent treatment with mesalazine in the prevention of diverticulitis recurrence: a randomised multicentre pilot double-blind placebo-controlled study of 24-month duration. Parente F., Bargiggia S., Prada A., Bortoli A., Giacosa A., Germanà B., Ferrari A., Casella G., De Pretis G., Miori G. 2013
One year intermittent rifaximin plus fibre supplementation vs. fibre supplementation alone to prevent diverticulitis recurrence: a proof-of-concept study. Lanas A., Ponce J., Bignamini A., Mearin F. 2013
Prospective Creation and Validation of the PREVENTT (Prediction and Enaction of Prevention Treatments Trigger) Scale for Surgical Site Infections (SSIs) in Patients With Diverticulitis. Bordeianou L., Cauley CE., Patel R., Bleday R., Mahmood S., Kennedy K., Ahmed KF., Yokoe D., Hooper D., Rubin M. 2019
Randomized clinical trial of elective resection versus observation in diverticulitis with extraluminal air or abscess initially managed conservatively You K. 2018
Tumour Characteristics of Patients with Colorectal Cancer after Acute Uncomplicated Diverticulitis. Ramphal W., Schreinemakers JMJ., Seerden TCJ., Gobardhan PD. 2018
Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. Tursi A., Brandimarte G., Daffinà R. 2002
Balsalazide and/or high-potency probiotic mixture (VSL#3) in maintaining remission after attack of acute, uncomplicated diverticulitis of the colon. Tursi A., Brandimarte G., Giorgetti GM., Elisei W., Aiello F. 2007
Routine screening for colon cancer after conservative treatment of diverticulitis. Schout PJ., Spillenaar Bilgen EJ., Groenen MJ. 2012
Yield of colonoscopy after recent CT-proven uncomplicated acute diverticulitis: a comparative cohort study. Daniels L., Ünlü Ç., de Wijkerslooth TR., Stockmann HB., Kuipers EJ., Boermeester MA., Dekker E. 2015
Is there anything we can modify among factors associated with morbidity following elective laparoscopic sigmoidectomy for diverticulitis? Silva-Velazco J., Stocchi L., Costedio M., Gorgun E., Kessler H., Remzi FH. 2016
Underlying Colorectal Cancer Was Rarely Detected After an Episode of Acute Diverticulitis: a Retrospective Analysis of 225 Patients. Khoury T., Mahamid M., Lubany A., Safadi M., Farah A., Sbeit W., Mari A. 2019
Is early colonoscopy beneficial in patients with CT-diagnosed diverticulitis? Elmi A., Hedgire SS., Pargaonkar V., Cao K., McDermott S., Harisinghani M. 2013
Colonoscopy following nonoperative management of uncomplicated diverticulitis may not be warranted. Brar MS., Roxin G., Yaffe PB., Stanger J., MacLean AR., Buie WD. 2013
Role of endoscopy after an acute episode of diverticulitis: analysis of a cohort of Portuguese patients from a tertiary referral center. Meireles LC., Fernandes SR., Ribeiro LC., Velosa J. 2015
Colonoscopy after the first episode of acute diverticulitis: challenging management paradigms. Horesh N., Saeed Y., Horesh H., Berger Y., Speter C., Pery R., Rosin D., Gutman M., Zmora O. 2016
Routine Colonoscopy after Acute Uncomplicated Diverticulitis - Challenging a Putative Indication. Andrade P., Ribeiro A., Ramalho R., Lopes S., Macedo G. 2017
Diagnostic impact of routine colonoscopy following acute diverticulitis: A multicenter study in 808 patients and controls. Lecleire S., Nahon S., Alatawi A., Antonietti M., Chaput U., Di-Fiore A., Alhameedi R., Marteau P., Ducrotté P., Dray X. 2014
Risk of colon cancer after computed tomography-diagnosed acute diverticulitis: is routine colonoscopy necessary? Sallinen V., Mentula P., Leppäniemi A. 2014
Is early colonoscopy after CT-diagnosed diverticulitis still necessary? Suhardja TS., Norhadi S., Seah EZ., Rodgers-Wilson S. 2017
Determinants of treatment and outcomes of diverticular abscesses. Mali J., Mentula P., Leppäniemi A., Sallinen V. 2019
Is colonoscopy still mandatory after a CT diagnosis of left-sided diverticulitis: can colorectal cancer be confidently excluded? Lau KC., Spilsbury K., Farooque Y., Kariyawasam SB., Owen RG., Wallace MH., Makin GB. 2011
Do we need colonoscopy following acute diverticulitis detected on computed tomography to exclude colorectal malignancy? Choi YH., Koh SJ., Kim JW., Kim BG., Lee KL., Im JP., Kim JS., Jung HC. 2014
The feasibility and risk of early colonoscopy in acute diverticulitis: a prospective controlled study. Lahat A., Yanai H., Menachem Y., Avidan B., Bar-Meir S. 2007
Retrospective comparison of long-term ten-day/month rifaximin or mesalazine in prevention of relapse in acute diverticulitis. Festa V., Spila Alegiani S., Chiesara F., Moretti A., Bianchi M., Dezi A., Traversa G., Koch M. 2017
Long-term safety of once-daily multimatrix mesalazine: A pooled clinical trials analysis Silva Sanchez SD, H Wan, P Streck, D Willshire, JB Raskin 2014
Routine lower gastrointestinal endoscopy for radiographically confirmed acute diverticulitis. In whom and when is it indicated? Seoane Urgorri A., Zaffalon D., Pera Román M., Batlle García M., Riu Pons F., Dedeu Cusco JM., Pantaleón Sánchez M., Bessa Caserras X., Barranco Priego L., Álvarez-González MA. 2018
Short-term Intravenous Antibiotic Treatment in Uncomplicated Diverticulitis Does Not Increase the Risk of Recurrence Compared to Long-term Treatment. Scarpa CR., Buchs NC., Poncet A., Konrad-Mugnier B., Gervaz P., Morel P., Ris F. 2015
Prevalence of colorectal cancer in acute uncomplicated diverticulitis and the role of the interval colonoscopy. Soh NYT., Chia DKA., Teo NZ., Ong CJM., Wijaya R. 2018
Outpatient treatment of acute diverticulitis: rates and predictors of failure. Etzioni DA., Chiu VY., Cannom RR., Burchette RJ., Haigh PI., Abbas MA. 2010
An 18-Year Nationwide Cohort Study on The Association Between Diverticulitis and Colon Cancer. Mortensen LQ., Burcharth J., Andresen K., Pommergaard HC., Rosenberg J. 2017
A randomized controlled study of mesalamine after acute diverticulitis: results of the DIVA trial. Stollman N., Magowan S., Shanahan F., Quigley EM. 2013
Follow up colonoscopy may be omissible in uncomplicated left-sided acute diverticulitis diagnosed with CT- a retrospective cohort study. O'Donohoe N., Chandak P., Likos-Corbett M., Yee J., Hurndall K., Rao C., Engledow AH. 2019
Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial. Jaung R., Nisbet S., Gosselink MP., Di Re A., Keane C., Lin A., Milne T., Su'a B., Rajaratnam S., Ctercteko G., Hsee L., Rowbotham D., Hill A., Bissett I. 2020
Findings on Colonoscopy after Diverticulitis: A Multicenter Review. Studniarek A., Kochar K., Warner C., Eftaiha S., Naffouj S., Borsuk DJ., Mellgren A., Park JJ., Cintron J., Harrison J. 2019
The Necessity of a Colonoscopy after an Acute Diverticulitis Event in Adults Less Than 50 Years Old. Alcantar DC., Rodriguez C., Fernandez R., Kumar S., Junia C. 2019




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