Study Preview
Study Title and Description
Tumour Characteristics of Patients with Colorectal Cancer after Acute Uncomplicated Diverticulitis.
Key Questions Addressed
3 | KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors? |
Primary Publication Information
Title | Tumour Characteristics of Patients with Colorectal Cancer after Acute Uncomplicated Diverticulitis. |
Author | Ramphal W., Schreinemakers JMJ., Seerden TCJ., Gobardhan PD. |
Country | Department of Surgery Amphia Hospital Breda, Breda, the Netherlands. |
Year | 2018 |
Numbers |
Pubmed ID: 29945147 |
Secondary Publication Information
UI | Title | Author | Country | Year | |
---|---|---|---|---|---|
What is the Risk of Colorectal Cancer After an Episode of Acute Diverticulitis in Conservatively Treated Patients? | Ramphal W., Schreinemakers JM., Seerden TC., Crolla RM., Rijken AM., Gobardhan PD. | Departments of *Surgery†Gastroenterology, Amphia Hospital, Breda, The Netherlands. | 2016 |
Extraction Form: KQ 3: Colonoscopy
Arms
Number | Title | Description | Comments |
---|---|---|---|
1 | Colonoscopy |
Question... Follow Up | Answer | Follow-up Answer | |
---|---|---|---|
Study design | Single group, with subgroup analyses | ||
Single group, with subgroup analyses | |||
Single group, with subgroup analyses | |||
Single group, with subgroup analyses | |||
Single group, with subgroup analyses | |||
Single group, with subgroup analyses | |||
Single group, with subgroup analyses | |||
if not an RCT, what was the directionality? | Retrospective | ||
Funder | Not reported (or unclear) | ||
Start and end years of the study | 2008 | ||
2013 | |||
Inclusion criteria | Hinchey 0 and 1 | ||
Exclusion criteria | Hinchey II-IV, previous colorectal cancer, previous episodes of diverticulitis | ||
Specific population? | Hx uncomplicated diverticulitis only | ||
Other (define) ... | Hinchey 0 and I only | ||
Note/Comment about Design (or overall study) | |||
Country | Netherlands | ||
Comparison of colonoscopy vs. no colonoscopy? | Yes | ||
Comparison of diverticulitis vs health control? | No | ||
Subgroup analyses? | Alarm symptoms | ||
Alarm symptoms | |||
Alarm symptoms | |||
Alarm symptoms |
Baseline Characteristics
Question | Colonoscopy | Total | Comments | ||
---|---|---|---|---|---|
Answer | Follow-up | Answer | Follow-up | ||
Participant race/ethnicity characteristics | Male | NR | |||
Participant age, continuous | 59 | ||||
Age >=50, % | No data entered. | ||||
Participants with Un/Complicated Diverticulitis | No data entered. | ||||
Note/Comment about baseline characteristics | No data entered. | ||||
Alarm symptoms | rectal bleeding, persistent abdominal pain, unintentional weight loss | ||||
32 |
Results & Comparisons
Results Data
Outcome: Colorectal cancer Population: All Participants | ||
---|---|---|
Time Point | Measure | Colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 645 |
Counts | 10 | |
Percentage | 1.6 | |
note | among 10 identified colorectal cancer cases, 2 had a family history of CRC and 1 had a positive family history for Crohn’s disease |
Outcome: Colorectal cancer Population: Patients with alarm symptoms | ||
---|---|---|
Time Point | Measure | Colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 205 [1] |
Counts | 9 | |
Percentage | 4.4 | |
P between subgroups | 0.0002 (alarm vs no alarm) | |
Footnotes | ||
1. The difference between the occurrence of CRC among the people who underwent colonoscopy in the two groups (alarm vs no alarm) is significant (p value 0.0002). |
Outcome: Colorectal cancer Population: Patients with no alarm symptoms | ||
---|---|---|
Time Point | Measure | Colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 440 |
Counts | 1 | |
Percentage | 0.2 |
Outcome: Colorectal cancer death Population: All Participants | ||
---|---|---|
Time Point | Measure | Colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 645 |
Counts | 5 | |
Percentage | 0.78 |
Quality Dimensions
Dimension | Value | Notes | Comments |
---|---|---|---|
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? | Yes | ||
Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? | Yes | ||
If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? | No |
Quality Rating
No quality rating data was found.