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Study Title and Description

Role of endoscopy after an acute episode of diverticulitis: analysis of a cohort of Portuguese patients from a tertiary referral center.



Key Questions Addressed
3 KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors?
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Primary Publication Information
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TitleData
Title Role of endoscopy after an acute episode of diverticulitis: analysis of a cohort of Portuguese patients from a tertiary referral center.
Author Meireles LC., Fernandes SR., Ribeiro LC., Velosa J.
Country Department of Gastroenterology and Hepatology, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
Year 2015
Numbers Pubmed ID: 26378691

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: KQ 3: Colonoscopy
Arms
Number Title Description Comments
1 Colonoscopy
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Design Details
Question... Follow Up Answer Follow-up Answer
Study design Single group, with subgroup analyses
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Single group, with subgroup analyses
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Single group, with subgroup analyses
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if not an RCT, what was the directionality? Retrospective
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Funder Not reported (or unclear)
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Start and end years of the study 2004
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2013
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Inclusion criteria patients subjected to endoscopy following the primary episode of diverticulitis
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Exclusion criteria patients with a history of colorectal cancer, diverticular bleeding, or who underwent emergency surgery
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Specific population? No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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Note/Comment about Design (or overall study) no subgroup analysis results (could be extracted) were reported in terms of sex
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Country Portugal
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Comparison of colonoscopy vs. no colonoscopy? No
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Comparison of diverticulitis vs health control? No
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Subgroup analyses? Age <> 50
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Male vs. female
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Complicated vs uncomplicated D
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Age <> 50
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Male vs. female
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Complicated vs uncomplicated D
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Age <> 50
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Male vs. female
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Complicated vs uncomplicated D
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Age <> 50
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Male vs. female
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Complicated vs uncomplicated D
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Baseline Characteristics
Question Colonoscopy Total Comments
AnswerFollow-up AnswerFollow-up
Participant race/ethnicity characteristics Male 49.6 Male 49.6
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Participant age, continuous 64.4 64.4
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13.5 13.5
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23 23
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103 103
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Age >=50, % NR NR
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Participants with Un/Complicated Diverticulitis Complicated diverticulitis 28.8 Complicated diverticulitis 28.8
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Uncomplicated diverticulitis 81.2 Uncomplicated diverticulitis 81.2
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Note/Comment about baseline characteristics No data entered.
Alarm symptoms No data entered.



Results & Comparisons


Results Data
Outcome: Colorectal cancer      Population: All Participants
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 427 [1]
Counts 20
Percentage 4.7
NNT 27 [4]
note NNT calculation: using an estimated prevalence of colorectal neoplasia in the Portuguese population of 0.76%
Footnotes
1. Each additional 10 years increased the probability of diagnosing CRC by 3% (P< 0.01)
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4. Using an estimated prevalence of colorectal neoplasia in the Portuguese population of 0.76%
Outcome: Colorectal cancer      Population: complicated diverticulitis
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 80
Counts 8
Percentage 10
NNT 11
Outcome: Colorectal cancer      Population: uncomplicated diverticulitis
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 347
Counts 12
Percentage 3.5
NNT 39
Outcome: Colorectal cancer      Population: <50 years old
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 69 [5]
Counts 3
Percentage 4.3
note the "N Analyzed" was calculated based on the webplot digitizer
Footnotes
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5. calculated based on the webplot digitizer
Outcome: Colorectal cancer      Population: >50 years old
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 342 [3]
Counts 17
Percentage 5.0
note the "N Analyzed" was calculated based on the webplot digitizer
Footnotes
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3. calculated based on the webplot digitizer
Outcome: Adenoma, high grade dysplasia      Population: All Participants
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 427
Counts 28
Percentage 6.6
Outcome: Adenoma, high grade dysplasia      Population: complicated diverticulitis
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 80
Counts 9
Percentage 11.3
Outcome: Adenoma, high grade dysplasia      Population: uncomplicated diverticulitis
Time Point Measure Colonoscopy


Enter a numeric value or title (required) years

N Analyzed 347
Counts 19
Percentage 5.5


Quality Dimensions
Dimension Value Notes Comments
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? Yes
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Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? Yes
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If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? No
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Quality Rating
No quality rating data was found.