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Study Title and Description

Diagnostic impact of routine colonoscopy following acute diverticulitis: A multicenter study in 808 patients and controls.



Key Questions Addressed
3 KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors?
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Primary Publication Information
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TitleData
Title Diagnostic impact of routine colonoscopy following acute diverticulitis: A multicenter study in 808 patients and controls.
Author Lecleire S., Nahon S., Alatawi A., Antonietti M., Chaput U., Di-Fiore A., Alhameedi R., Marteau P., Ducrotté P., Dray X.
Country Gastroenterology Department, Rouen University Hospital, University of Rouen, Rouen, France ; Paris Diderot University, Sorbonne Paris Cité, Paris, France ; Department of Gastroenterology, Hôpital Lariboisière, Paris, France.
Year 2014
Numbers Pubmed ID: 25083288

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: KQ 3: Colonoscopy
Arms
Number Title Description Comments
1 Acute diverticulitis
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2 Control group sex and age matched to the diverticulitis group
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Design Details
Question... Follow Up Answer Follow-up Answer
Study design NRCS (diverticulitis vs. healthy)
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NRCS (diverticulitis vs. healthy)
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if not an RCT, what was the directionality? Retrospective
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Funder Non-industry (fully)
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Start and end years of the study 2005
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2011
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Inclusion criteria Group 1: acute diverticulitis, underwent colonoscopy within 6 months following the acute episode Group 2: sex and age matched with a familial history of colorectal adenoma or neoplasia
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Exclusion criteria patients with haematochezia, recent change in bpwel habits, personal history of colorectal neoplasia, undergone colonoscopy within the 2 years before the episode of diverticulitis
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Specific population? No (anyone with Hx diverticulitis)
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Other (define) ...
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Note/Comment about Design (or overall study)
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Country France
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Comparison of colonoscopy vs. no colonoscopy? No
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Comparison of diverticulitis vs health control? Yes
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Baseline Characteristics
Question Acute diverticulitis Control group Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Participant race/ethnicity characteristics Male 41 Male 41 Male 41
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Participant age, continuous 60.9 60.7
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12.6 13.4
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Age >=50, % No data entered.
Participants with Un/Complicated Diverticulitis Complicated diverticulitis 10
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Note/Comment about baseline characteristics No data entered.
Alarm symptoms No data entered.



Results & Comparisons


Results Data
Outcome: Adenoma >=10 mm      Population: All Participants
Time Point Measure Acute diverticulitis Control group


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N Analyzed 404 404
Counts 9 23
Percentage 2.2 5.7
Outcome: Adenoma, high grade dysplasia      Population: All Participants
Time Point Measure Acute diverticulitis Control group


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N Analyzed 404 404
Counts 2 6
Percentage 0.5 1.4
Outcome: Adenoma, villous      Population: All Participants
Time Point Measure Acute diverticulitis Control group


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N Analyzed 404 404
Counts 3 3
Percentage 0.7 0.7
Outcome: Colorectal cancer      Population: All Participants
Time Point Measure Acute diverticulitis Control group


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N Analyzed 404 404
Counts 1 1
Percentage 0.25 0.25
P-Value
Outcome: Advance Adenoma      Population: All Participants Between-Arm Comparisons
Time Point Measure Acute diverticulitis Control group Comparison Measure Acute diverticulitis vs. Control group


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N Analyzed 404 404 0.01
Counts 11 27
Percentage 2.7 6.7


Quality Dimensions
Dimension Value Notes Comments
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? Yes
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Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? Yes
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If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? No
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Quality Rating
No quality rating data was found.