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Study Title and Description

Is colonoscopy still mandatory after a CT diagnosis of left-sided diverticulitis: can colorectal cancer be confidently excluded?



Key Questions Addressed
3 KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors?
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Primary Publication Information
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TitleData
Title Is colonoscopy still mandatory after a CT diagnosis of left-sided diverticulitis: can colorectal cancer be confidently excluded?
Author Lau KC., Spilsbury K., Farooque Y., Kariyawasam SB., Owen RG., Wallace MH., Makin GB.
Country Department of Surgery, Fremantle Hospital, Fremantle, Western Australia, Australia.
Year 2011
Numbers Pubmed ID: 21904141

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: KQ 3: Colonoscopy
Arms
Number Title Description Comments
1 Colonoscopy
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2 No Colonoscopy colonoscopy not reported
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Design Details
Question... Follow Up Answer Follow-up Answer
Study design NRCS (scopy vs. no scopy)
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NRCS (scopy vs. no scopy)
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NRCS (scopy vs. no scopy)
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NRCS (scopy vs. no scopy)
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if not an RCT, what was the directionality? Retrospective
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Funder Not reported (or unclear)
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Start and end years of the study 2003
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2009
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Inclusion criteria diverticulitis confirmed by CT, colonoscopy patients only included who had a follow up colonoscopy within 1 year from the date of CT scan
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Exclusion criteria colonoscopy >1 year from the date of CT scan
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Specific population? No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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Note/Comment about Design (or overall study) No colonoscopy arm means the data for colonoscopy not available.
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Country Australia
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Comparison of colonoscopy vs. no colonoscopy? Yes
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Comparison of diverticulitis vs health control? No
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Baseline Characteristics
Question Colonoscopy No Colonoscopy Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Participant race/ethnicity characteristics Male 53 Male 47.6 Male 49.2
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Participant age, continuous 15-39y: 7.2%, 40-64y: 55.5%, 65+: 37.3% 15-39y: 8.5%, 40-64y: 54.2%, 65+: 37.3% 15-39y: 8.1%, 40-64y: 54.6%, 65+: 37.3%
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Age >=50, % No data entered.
Participants with Un/Complicated Diverticulitis No data entered.
Note/Comment about baseline characteristics No data entered.
Alarm symptoms No data entered.



Results & Comparisons


Results Data
Outcome: Colorectal cancer      Population: All Participants
Time Point Measure Colonoscopy No Colonoscopy


Enter a numeric value or title (required) years

 N Analyzed 319 769
Counts 9 14
Percentage 2.8 1.8
Outcome: Adenoma >=10 mm      Population: All Participants
Time Point Measure Colonoscopy No Colonoscopy


Enter a numeric value or title (required) years

 N Analyzed 319
Counts 9
Percentage 2.6
Outcome: Adenoma, high grade dysplasia      Population: All Participants
Time Point Measure Colonoscopy No Colonoscopy


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 N Analyzed 319
Counts 0
Percentage 0
Outcome: moderately differentiated adenocarcinoma      Population: All Participants
Time Point Measure Colonoscopy No Colonoscopy


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 N Analyzed 319
Counts 1
Percentage 0.3
Outcome: AE: Perforation      Population: All Participants
Time Point Measure Colonoscopy No Colonoscopy


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 N Analyzed 319
Counts 0
Percentage 0


Quality Dimensions
Dimension Value Notes Comments
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? Yes
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Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? Yes
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If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? No
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Quality Rating
No quality rating data was found.