Study Preview
Study Title and Description
Do we need colonoscopy following acute diverticulitis detected on computed tomography to exclude colorectal malignancy?
Key Questions Addressed
3 | KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors? |
Primary Publication Information
Title | Do we need colonoscopy following acute diverticulitis detected on computed tomography to exclude colorectal malignancy? |
Author | Choi YH., Koh SJ., Kim JW., Kim BG., Lee KL., Im JP., Kim JS., Jung HC. |
Country | Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro Jongno-gu, Seoul, 110-744, Korea, crzyzs@naver.com. |
Year | 2014 |
Numbers |
Pubmed ID: 24723071 |
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: KQ 3: Colonoscopy
Arms
Number | Title | Description | Comments |
---|---|---|---|
1 | Diverticulitis with colonoscopy | ||
2 | Healthy controls | For each diverticulitis case, two age- (±5 years) and sex matched control individuals were identified from among healthy individuals who underwent screening colonoscopy | |
3 | Diverticulitis without colonoscopy |
Question... Follow Up | Answer | Follow-up Answer | |
---|---|---|---|
Study design | NRCS (diverticulitis vs. healthy) | ||
NRCS (diverticulitis vs. healthy) | |||
NRCS (diverticulitis vs. healthy) | |||
NRCS (diverticulitis vs. healthy) | |||
if not an RCT, what was the directionality? | Retrospective | ||
Funder | Not reported (or unclear) | ||
Start and end years of the study | 2001 | ||
2013 | |||
Inclusion criteria | underwent CT, followed by colonoscopy within a year and diagnosed with acute diverticulitis. For each diverticulitis case, two age- (±5 years) and sex matched control individuals were identified from among healthy individuals who underwent screening colonoscopy. | ||
Exclusion criteria | colorectal cancer, colorectal surgery, underwent colonoscopy 1 year prior to the diagnosis of diverticulitis. | ||
Specific population? | No (anyone with Hx diverticulitis) | ||
No (anyone with Hx diverticulitis) | |||
No (anyone with Hx diverticulitis) | |||
No (anyone with Hx diverticulitis) | |||
Note/Comment about Design (or overall study) | |||
Country | S Korea | ||
Comparison of colonoscopy vs. no colonoscopy? | Yes | ||
Comparison of diverticulitis vs health control? | Yes | ||
Subgroup analyses? | R vs L sided | ||
R vs L sided |
Baseline Characteristics
Question | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy | Total | Comments | ||||
---|---|---|---|---|---|---|---|---|---|
Answer | Follow-up | Answer | Follow-up | Answer | Follow-up | Answer | Follow-up | ||
Participant race/ethnicity characteristics | Male | 59.7 | Male | 59.9 | |||||
Participant age, continuous | 48.6 | 46.6 | |||||||
16.5 | 16.6 | ||||||||
Age >=50, % | No data entered. | ||||||||
Participants with Un/Complicated Diverticulitis | Complicated diverticulitis | 14.1 | Complicated diverticulitis | 8.2 | |||||
Uncomplicated diverticulitis | 85.9 | Uncomplicated diverticulitis | 91.8 | ||||||
Note/Comment about baseline characteristics | No data entered. | ||||||||
Alarm symptoms | No data entered. |
Results & Comparisons
Results Data
Outcome: Colorectal cancer Population: All Participants | Between-Arm Comparisons | |||||
---|---|---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy | Comparison Measure | Diverticulitis with colonoscopy vs. Healthy controls |
Enter a numeric value or title (required) years |
N Analyzed | 149 | 298 | 11.80 | ||
Counts | 11 | 2 | 2.58 | |||
Percentage | 7.4 | 0.7 | 53.95 | |||
0.001 |
Outcome: Colorectal cancer Population: Diverticulitis on the left side colon | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 23 | ||
Counts | 3 | |||
Percentage | 13 [1] | |||
P between subgroups | 0.679 (left vs right) | |||
Footnotes | ||||
1. p- value for the different between left and right diverticulitis is 0.679 |
Outcome: Colorectal cancer Population: Diverticulitis on the right side colon | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 126 | ||
Counts | 9 | |||
Percentage | 7.1 |
Outcome: Advanced Colonic Neoplasia Population: All Participants | Between-Arm Comparisons | |||||
---|---|---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy | Comparison Measure | Diverticulitis with colonoscopy vs. Healthy controls |
Enter a numeric value or title (required) years |
N Analyzed | 149 | 298 | 8.84 | ||
Counts | 16 | 4 | 2.90 | |||
Percentage | 10.7 | 1.3 | 26.96 | |||
<0.001 |
Outcome: Advanced Colonic Neoplasia Population: Diverticulitis on the left side of colon | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 23 | ||
Counts | 3 | |||
Percentage | 13 [1] | |||
P between subgroups | 0.715 (left vs right) | |||
Footnotes | ||||
1. p value for the difference between left and right diverticulitis is 0.715 |
Outcome: Advanced Colonic Neoplasia Population: Diverticulitis on the right side of colon | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 126 | ||
Counts | 13 | |||
Percentage | 10.3 |
Outcome: Advance Adenoma Population: All Participants | Between-Arm Comparisons | |||||
---|---|---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy | Comparison Measure | Diverticulitis with colonoscopy vs. Healthy controls |
Enter a numeric value or title (required) years |
N Analyzed | 149 | 298 | 5.14 | ||
Counts | 5 | 2 | 0.99 | |||
Percentage | 3.4 | 0.7 | 26.81 | |||
0.052 |
Outcome: Advance Adenoma Population: Diverticulitis on the left side of colon | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 23 | ||
Counts | 1 | |||
Percentage | 4.3 [1] | |||
P between subgroups | 0.052 (left vs right) | |||
Footnotes | ||||
1. p-value for the difference between left and right diverticulitis is 0.052 |
Outcome: Advance Adenoma Population: Diverticulitis on the right side of colon | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis with colonoscopy | Healthy controls | Diverticulitis without colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 126 | ||
Counts | 4 | |||
Percentage | 3.2 |
Quality Dimensions
Dimension | Value | Notes | Comments |
---|---|---|---|
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? | Yes | ||
Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? | Yes | ||
If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? | Yes |
Quality Rating
No quality rating data was found.