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Study Title and Description

The feasibility and risk of early colonoscopy in acute diverticulitis: a prospective controlled study.



Key Questions Addressed
3 KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors?
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Primary Publication Information
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TitleData
Title The feasibility and risk of early colonoscopy in acute diverticulitis: a prospective controlled study.
Author Lahat A., Yanai H., Menachem Y., Avidan B., Bar-Meir S.
Country Department of Gastroenterology, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Year 2007
Numbers Pubmed ID: 17554647

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: KQ 3: Colonoscopy
Arms
Number Title Description Comments
1 Colonoscopy (early) in-hospital colonoscopy
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2 Colonoscopy (late) late ambulatory colonoscopy at 6 weeks later
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Design Details
Question... Follow Up Answer Follow-up Answer
Study design RCT
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RCT
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Funder Not reported (or unclear)
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Start and end years of the study 2004
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2006
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Inclusion criteria All patients underwent abdominal CT, and only those with characteristic findings on CT compatible with the diagnosis of acute diverticulitis
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Exclusion criteria Patients with CT findings of pericolonic air or fluid adjacent to a diverticulum and, obviously, patients with free perforation; patients with a lesion seen on CT scan that was suspicious of colonic cancer; patients who had undergone a colonoscopy within the year prior to the current episode of acute diverticulitis
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Specific population? No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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Note/Comment about Design (or overall study)
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Country Israel
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Comparison of colonoscopy vs. no colonoscopy? No
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Comparison of diverticulitis vs health control? No
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Subgroup analyses? ... Other 1 ... early colonoscopy vs. late colonoscopy
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Baseline Characteristics
Question Colonoscopy (early) Colonoscopy (late) Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up
Participant race/ethnicity characteristics Male 31.1 Male 34.1 Male 32.6
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Participant age, continuous 60.5 60.3
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11.4 14.7
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Age >=50, % NR NR NR
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Participants with Un/Complicated Diverticulitis Not reported Not reported Not reported
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Note/Comment about baseline characteristics No data entered.
Alarm symptoms No data entered.



Results & Comparisons


Results Data
P-Value
Outcome: no show for the colonoscopy      Population: All Participants Between-Arm Comparisons
Time Point Measure Colonoscopy (early) Colonoscopy (late) Comparison Measure Colonoscopy (early) vs. Colonoscopy (late)


Enter a numeric value or title (required) years

N Analyzed 45 41 0.033
Counts 3 10
Percentage 6.7 24.4
P-Value
Outcome: Failed/incomplete procedure      Population: All Participants Between-Arm Comparisons
Time Point Measure Colonoscopy (early) Colonoscopy (late) Comparison Measure Colonoscopy (early) vs. Colonoscopy (late)


Enter a numeric value or title (required) years

N Analyzed 45 41 NS
Counts 8 3
Percentage 17.8 7.3
Outcome: Procedural complication      Population: All Participants
Time Point Measure Colonoscopy (early) Colonoscopy (late)


Enter a numeric value or title (required) years

N Analyzed 45 41
Counts 0 0
Percentage 0 0
Outcome: Adenoma >=10 mm      Population: All Participants
Time Point Measure Colonoscopy (early) Colonoscopy (late)


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N Analyzed 45 41
Counts 1 1
Percentage 2.2 2.4
Outcome: No show or incomplete exam      Population: All Participants
Time Point Measure Colonoscopy (early) Colonoscopy (late)


Enter a numeric value or title (required) years

N Analyzed 45 41
Counts 11 13
Percentage 24.4 31.7


Quality Dimensions
Dimension Value Notes Comments
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? Yes
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Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? Yes
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If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? No
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Quality Rating
No quality rating data was found.