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Study Title and Description

An 18-Year Nationwide Cohort Study on The Association Between Diverticulitis and Colon Cancer.



Key Questions Addressed
3 KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors?
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Primary Publication Information
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TitleData
Title An 18-Year Nationwide Cohort Study on The Association Between Diverticulitis and Colon Cancer.
Author Mortensen LQ., Burcharth J., Andresen K., Pommergaard HC., Rosenberg J.
Country Department of Surgery, Center for Perioperative Optimization, Herlev Hospital, University of Copenhagen, Denmark.
Year 2017
Numbers Pubmed ID: 27192351

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: KQ 3: Colonoscopy
Arms
Number Title Description Comments
1 Diverticulitis patients with colonoscopy
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2 Diverticulitis patients without colonoscopy
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3 Diverticulitis-free controls with colonoscopy
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Design Details
Question... Follow Up Answer Follow-up Answer
Study design NRCS (scopy vs. no scopy)
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NRCS (diverticulitis vs. healthy)
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NRCS (scopy vs. no scopy)
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NRCS (diverticulitis vs. healthy)
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NRCS (scopy vs. no scopy)
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NRCS (diverticulitis vs. healthy)
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NRCS (scopy vs. no scopy)
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NRCS (diverticulitis vs. healthy)
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if not an RCT, what was the directionality? Prospective
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Funder Non-industry (fully)
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Start and end years of the study 1995
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2012
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Inclusion criteria Patients hospitalized for symptomatic diverticulitis
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Exclusion criteria Patients whose diagnoses of diverticulitis were registered as non-primary or if the registrations of diverticulitis were from outpatient clinics
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Specific population? No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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No (anyone with Hx diverticulitis)
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Note/Comment about Design (or overall study) A population-based cohort study based on longitudinal Danish national registers
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Comparison of colonoscopy vs. no colonoscopy? Yes
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Comparison of diverticulitis vs health control? Yes
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Baseline Characteristics
Question Diverticulitis patients with colonoscopy Diverticulitis patients without colonoscopy Diverticulitis-free controls with colonoscopy Total Comments
AnswerFollow-up AnswerFollow-up AnswerFollow-up AnswerFollow-up
Participant race/ethnicity characteristics Male 39.4 Male 39.4 Male 39.4
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Participant age, continuous No data entered.
Age >=50, % NR NR NR
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Participants with Un/Complicated Diverticulitis Not reported Not reported Not reported
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Note/Comment about baseline characteristics We assume the same background information between 585 patients who had their first diagnosis of colon cancer before their first diagnosis of diverticulitis and the 39911 patients in otherwise. No specific background information was provided for these 39911 patients included for analyses. We assume the same background information between 22646 patients who underwent colonoscopy and 17265 patients without colonoscopy. No specific background information was provided for these two arms. Compared to the control arm, the diverticulitis patient arm have relatively higher rates of other diseases (2.3% vs. 0.8% for ulcerative colitis,1.1% vs. 0.3% for Crohn’s disease, 12.3% vs. 8.5% for diabetes mellitus).
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Alarm symptoms No data entered.



Results & Comparisons


Results Data
Outcome: Colorectal cancer      Population: All Participants
Time Point Measure Diverticulitis patients with colonoscopy Diverticulitis patients without colonoscopy Diverticulitis-free controls with colonoscopy


Enter a numeric value or title (required) years

N Analyzed 22646 17265 40777
Counts 542 596 3087
Percentage 2.4 3.5 7.6


Quality Dimensions
Dimension Value Notes Comments
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? Yes
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Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? Yes
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If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? Yes
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Quality Rating
No quality rating data was found.