Study Preview
Study Title and Description
An 18-Year Nationwide Cohort Study on The Association Between Diverticulitis and Colon Cancer.
Key Questions Addressed
3 | KQ 3: What are the benefits and harms of colonoscopy (or other colon imaging test) following an episode of acute diverticulitis? KQ 3a. What is the incidence of malignant and premalignant colon tumors found by colonoscopy, and what is the incidence of colon cancer mortality among patients undergoing screening? KQ 3b. What are the procedure-related and other harms of colonoscopy or CT colonography? KQ 3c. What is the frequency of inadequate imaging due to intolerance or technical feasibility? • Do the benefits and harms vary by patient characteristics, course of illness, or other factors? |
Primary Publication Information
Title | An 18-Year Nationwide Cohort Study on The Association Between Diverticulitis and Colon Cancer. |
Author | Mortensen LQ., Burcharth J., Andresen K., Pommergaard HC., Rosenberg J. |
Country | Department of Surgery, Center for Perioperative Optimization, Herlev Hospital, University of Copenhagen, Denmark. |
Year | 2017 |
Numbers |
Pubmed ID: 27192351 |
Secondary Publication Information
There are currently no secondary publications defined for this study.
Extraction Form: KQ 3: Colonoscopy
Arms
Number | Title | Description | Comments |
---|---|---|---|
1 | Diverticulitis patients with colonoscopy | ||
2 | Diverticulitis patients without colonoscopy | ||
3 | Diverticulitis-free controls with colonoscopy |
Question... Follow Up | Answer | Follow-up Answer | |
---|---|---|---|
Study design | NRCS (scopy vs. no scopy) | ||
NRCS (diverticulitis vs. healthy) | |||
NRCS (scopy vs. no scopy) | |||
NRCS (diverticulitis vs. healthy) | |||
NRCS (scopy vs. no scopy) | |||
NRCS (diverticulitis vs. healthy) | |||
NRCS (scopy vs. no scopy) | |||
NRCS (diverticulitis vs. healthy) | |||
if not an RCT, what was the directionality? | Prospective | ||
Funder | Non-industry (fully) | ||
Start and end years of the study | 1995 | ||
2012 | |||
Inclusion criteria | Patients hospitalized for symptomatic diverticulitis | ||
Exclusion criteria | Patients whose diagnoses of diverticulitis were registered as non-primary or if the registrations of diverticulitis were from outpatient clinics | ||
Specific population? | No (anyone with Hx diverticulitis) | ||
No (anyone with Hx diverticulitis) | |||
No (anyone with Hx diverticulitis) | |||
No (anyone with Hx diverticulitis) | |||
Note/Comment about Design (or overall study) | A population-based cohort study based on longitudinal Danish national registers | ||
Comparison of colonoscopy vs. no colonoscopy? | Yes | ||
Comparison of diverticulitis vs health control? | Yes |
Baseline Characteristics
Question | Diverticulitis patients with colonoscopy | Diverticulitis patients without colonoscopy | Diverticulitis-free controls with colonoscopy | Total | Comments | ||||
---|---|---|---|---|---|---|---|---|---|
Answer | Follow-up | Answer | Follow-up | Answer | Follow-up | Answer | Follow-up | ||
Participant race/ethnicity characteristics | Male | 39.4 | Male | 39.4 | Male | 39.4 | |||
Participant age, continuous | No data entered. | ||||||||
Age >=50, % | NR | NR | NR | ||||||
Participants with Un/Complicated Diverticulitis | Not reported | Not reported | Not reported | ||||||
Note/Comment about baseline characteristics | We assume the same background information between 585 patients who had their first diagnosis of colon cancer before their first diagnosis of diverticulitis and the 39911 patients in otherwise. No specific background information was provided for these 39911 patients included for analyses. | We assume the same background information between 22646 patients who underwent colonoscopy and 17265 patients without colonoscopy. No specific background information was provided for these two arms. | Compared to the control arm, the diverticulitis patient arm have relatively higher rates of other diseases (2.3% vs. 0.8% for ulcerative colitis,1.1% vs. 0.3% for Crohn’s disease, 12.3% vs. 8.5% for diabetes mellitus). | ||||||
Alarm symptoms | No data entered. |
Results & Comparisons
Results Data
Outcome: Colorectal cancer Population: All Participants | ||||
---|---|---|---|---|
Time Point | Measure | Diverticulitis patients with colonoscopy | Diverticulitis patients without colonoscopy | Diverticulitis-free controls with colonoscopy |
Enter a numeric value or title (required) years |
N Analyzed | 22646 | 17265 | 40777 |
Counts | 542 | 596 | 3087 | |
Percentage | 2.4 | 3.5 | 7.6 |
Quality Dimensions
Dimension | Value | Notes | Comments |
---|---|---|---|
Q23: NHLBI - Were eligibility/selection criteria for the study population prespecified and clearly described? | Yes | ||
Q25: NHLBI - Were the outcome measures prespecified, clearly defined, valid, reliable, and assessed consistently across all study participants? | Yes | ||
If this study was an NRCS or a single-group study, did the study report adjusted results that were for differences between groups (in the case of NRCSs) or differences between subgroups (in the case of single group studies)? | Yes |
Quality Rating
No quality rating data was found.