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Project: Management of Primary Headache During Pregnancy

Public Report Complete



Project Summary

Title and Description


Key Questions


Associated Extraction Forms

Title Created by Key Questions Addressed Form Notes
Extraction form for Direct Evidence (Primary Studies) Ian Saldanha 1, 2
Extraction Form for Indirect Evidence (Systematic Reviews) Ian Saldanha 3, 4


Associated Studies (each link opens a new tab)

Title Author Year
Metoclopramide and Diphenhydramine: A Randomized Controlled Trial of a Treatment for Headache in Pregnancy when Acetaminophen Alone Is Ineffective (MAD Headache Study). Childress KMS., Dothager C., Gavard JA., Lebovitz S., Laska C., Mostello DJ. 2018
Final results from the 16-year sumatriptan, naratriptan, and treximet pregnancy registry. Ephross SA., Sinclair SM. 2014
Delivery outcome after maternal use of drugs for migraine: a register study in Sweden. Källén B., Nilsson E., Otterblad Olausson P. 2011
Acupuncture for tension-type headache in pregnancy: A prospective, randomized, controlled study J.B. Guerreiro da Silva a, M.U. Nakamurab, J.A. Cordeiro a, L. Kulay b 2012
Nonpharmacological management of headaches during pregnancy. Marcus DA., Scharff L., Turk DC. 1995
Nonpharmacological management of headaches during pregnancy. Marcus DA., Scharff L., Turk DC. 1995
Peripheral nerve blocks in the treatment of migraine in pregnancy. Govindappagari S., Grossman TB., Dayal AK., Grosberg BM., Vollbracht S., Robbins MS. 2014
Topiramate monotherapy use in women with and without epilepsy: pregnancy and neonatal outcomes. Castilla-Puentes R., Ford L., Manera L., Kwarta RF., Ascher S., Li Q. 2014
A non-pharmacological treatment of vascular headache during pregnancy. Hickling EJ., Silverman DJ., Loos W. 1990
Pregnancy outcome after anti-migraine triptan use: A prospective observational cohort study. Spielmann K., Kayser A., Beck E., Meister R., Schaefer C. 2018
Pregnancy and perinatal outcomes in migraineurs using sumatriptan: a prospective study. O'Quinn S., Ephross SA., Williams V., Davis RL., Gutterman DL., Fox AW. 1999
Pregnancy outcome following prescription for sumatriptan. Olesen C., Steffensen FH., Sorensen HT., Nielsen GL., Olsen J. 2000
Pregnancy outcome following first trimester exposure to sumatriptan. Shuhaiber S., Pastuszak A., Schick B., Matsui D., Spivey G., Brochu J., Koren G. 1998
Triptan safety during pregnancy: a Norwegian population registry study. Nezvalová-Henriksen K., Spigset O., Nordeng H. 2013
Triptan exposure during pregnancy and the risk of major congenital malformations and adverse pregnancy outcomes: results from the Norwegian Mother and Child Cohort Study. Nezvalová-Henriksen K., Spigset O., Nordeng H. 2010
Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. Bhola R., Kinsella E., Giffin N., Lipscombe S., Ahmed F., Weatherall M., Goadsby PJ. 2015
Depression drug treatment outcomes in pregnancy and the postpartum period: a systematic review and meta-analysis. McDonagh MS., Matthews A., Phillipi C., Romm J., Peterson K., Thakurta S., Guise JM. 2014
Depression drug treatment outcomes in pregnancy and the postpartum period: a systematic review and meta-analysis. McDonagh MS., Matthews A., Phillipi C., Romm J., Peterson K., Thakurta S., Guise JM. 2014
The risk of congenital malformations associated with exposure to β-blockers early in pregnancy: a meta-analysis. Yakoob MY., Bateman BT., Ho E., Hernandez-Diaz S., Franklin JM., Goodman JE., Hoban RA. 2013
Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Abalos E., Duley L., Steyn DW., Gialdini C. 2018
Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Abalos E., Duley L., Steyn DW., Gialdini C. 2018
Comparative efficacy and safety of oral antihypertensive agents in pregnant women with chronic hypertension: a network metaanalysis. Bellos I., Pergialiotis V., Papapanagiotou A., Loutradis D., Daskalakis G. 2020
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. Veroniki AA., Cogo E., Rios P., Straus SE., Finkelstein Y., Kealey R., Reynen E., Soobiah C., Thavorn K., Hutton B., Hemmelgarn BR., Yazdi F., D'Souza J., MacDonald H., Tricco AC. 2017
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. Veroniki AA., Cogo E., Rios P., Straus SE., Finkelstein Y., Kealey R., Reynen E., Soobiah C., Thavorn K., Hutton B., Hemmelgarn BR., Yazdi F., D'Souza J., MacDonald H., Tricco AC. 2017
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. Veroniki AA., Cogo E., Rios P., Straus SE., Finkelstein Y., Kealey R., Reynen E., Soobiah C., Thavorn K., Hutton B., Hemmelgarn BR., Yazdi F., D'Souza J., MacDonald H., Tricco AC. 2017
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. Veroniki AA., Cogo E., Rios P., Straus SE., Finkelstein Y., Kealey R., Reynen E., Soobiah C., Thavorn K., Hutton B., Hemmelgarn BR., Yazdi F., D'Souza J., MacDonald H., Tricco AC. 2017
Comparative safety of anti-epileptic drugs during pregnancy: a systematic review and network meta-analysis of congenital malformations and prenatal outcomes. Veroniki AA., Cogo E., Rios P., Straus SE., Finkelstein Y., Kealey R., Reynen E., Soobiah C., Thavorn K., Hutton B., Hemmelgarn BR., Yazdi F., D'Souza J., MacDonald H., Tricco AC. 2017
Safety of non-steroidal anti-inflammatory drugs in the postpartum period among women with hypertensive disorders of pregnancy: a meta-analysis. Bellos I., Pergialiotis V., Antsaklis A., Loutradis D., Daskalakis G. 2020
Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: a systematic evidence review for the U.S. Preventive Services Task Force. Henderson JT., Whitlock EP., O'Connor E., Senger CA., Thompson JH., Rowland MG. 2014
Aspirin for prevention of preeclampsia in women with historical risk factors: a systematic review. Coomarasamy A., Honest H., Papaioannou S., Gee H., Khan KS. 2003
Antiplatelet agents for preventing pre-eclampsia and its complications. Duley L., Henderson-Smart DJ., Meher S., King JF. 2007
Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss. Hamulyák EN., Scheres LJ., Marijnen MC., Goddijn M., Middeldorp S. 2020
Association of Treatments for Myeloproliferative Neoplasms During Pregnancy With Birth Rates and Maternal Outcomes: A Systematic Review and Meta-analysis. Maze D., Kazi S., Gupta V., Malinowski AK., Fazelzad R., Shah PS., Shehata N. 2019
Maternal adverse effects of different antenatal magnesium sulphate regimens for improving maternal and infant outcomes: a systematic review. Bain ES., Middleton PF., Crowther CA. 2013
Magnesium supplementation in pregnancy. Makrides M., Crosby DD., Bain E., Crowther CA. 2014
The fetal safety of benzodiazepines: an updated meta-analysis. Enato E., Moretti M., Koren G. 2011
Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Park-Wyllie L., Mazzotta P., Pastuszak A., Moretti ME., Beique L., Hunnisett L., Friesen MH., Jacobson S., Kasapinovic S., Chang D., Diav-Citrin O., Chitayat D., Nulman I., Einarson TR., Koren G. 2000
The Risk of Adverse Pregnancy Outcome After First Trimester Exposure to H1 Antihistamines: A Systematic Review and Meta-Analysis. Etwel F., Faught LH., Rieder MJ., Koren G. 2017
Systematic review with meta-analysis: the risks of proton pump inhibitors during pregnancy. Li CM., Zhernakova A., Engstrand L., Wijmenga C., Brusselaers N. 2020
Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies. Masarwa R., Levine H., Gorelik E., Reif S., Perlman A., Matok I. 2018
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. Hammers AL., Sanchez-Ramos L., Kaunitz AM. 2015
Does low-dose aspirin initiated before 11 weeks' gestation reduce the rate of preeclampsia? Chaemsaithong P., Cuenca-Gomez D., Plana MN., Gil MM., Poon LC. 2020
Use of ondansetron during pregnancy and the risk of major congenital malformations: A systematic review and meta-analysis. Kaplan YC., Richardson JL., Keskin-Arslan E., Erol-Coskun H., Kennedy D. 2019
Risk of malformation after ondansetron in pregnancy: An updated systematic review and meta-analysis. Picot C., Berard A., Grenet G., Ripoche E., Cucherat M., Cottin J. 2020
Pregnancy outcome following prenatal exposure to triptan medications: a meta-analysis. Marchenko A., Etwel F., Olutunfese O., Nickel C., Koren G., Nulman I. 2015
Obstetric and neonatal outcomes after antipsychotic medication exposure in pregnancy. Coughlin CG., Blackwell KA., Bartley C., Hay M., Yonkers KA., Bloch MH. 2015
Pregnancy Outcomes Following In Utero Exposure to Second-Generation Antipsychotics: A Systematic Review and Meta-Analysis. Terrana N., Koren G., Pivovarov J., Etwel F., Nulman I. 2015
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Weston J., Bromley R., Jackson CF., Adab N., Clayton-Smith J., Greenhalgh J., Hounsome J., McKay AJ., Tudur Smith C., Marson AG. 2016
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Weston J., Bromley R., Jackson CF., Adab N., Clayton-Smith J., Greenhalgh J., Hounsome J., McKay AJ., Tudur Smith C., Marson AG. 2016
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Weston J., Bromley R., Jackson CF., Adab N., Clayton-Smith J., Greenhalgh J., Hounsome J., McKay AJ., Tudur Smith C., Marson AG. 2016
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Weston J., Bromley R., Jackson CF., Adab N., Clayton-Smith J., Greenhalgh J., Hounsome J., McKay AJ., Tudur Smith C., Marson AG. 2016
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Weston J., Bromley R., Jackson CF., Adab N., Clayton-Smith J., Greenhalgh J., Hounsome J., McKay AJ., Tudur Smith C., Marson AG. 2016




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