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Study Title and Description

Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.



Key Questions Addressed
4 Indirect Evidence (Systematic Reviews): KQ 2 - What are the (comparative) benefits and harms of interventions to treat acute attacks of primary headache in women who are pregnant (or attempting to become pregnant), postpartum, or breastfeeding?
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Primary Publication Information
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TitleData
Title Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis.
Author Hammers AL., Sanchez-Ramos L., Kaunitz AM.
Country Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL. Electronic address: amy.hammers@jax.ufl.edu.
Year 2015
Numbers Pubmed ID: 25448524

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Extraction Form for Indirect Evidence (Systematic Reviews)
Arms
No arms have been defined in this extraction form.

Design Details
Question... Follow Up Answer Follow-up Answer
How many DATABASES did the authors search? 2
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What was the YEAR of the last search? 2014
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How many STUDIES were included in the review? 27
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What INTERVENTIONS were addressed? NSAIDs
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Indomethacin
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Were MATERNAL adverse events reported? No
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Were FETAL/CHILD adverse events reported? Yes
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AMSTAR Item 1 - Did the authors specify the research questions and inclusion criteria for the SR? Yes
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AMSTAR Item 4 - Did the SR authors use a comprehensive literature search strategy? Yes
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AMSTAR Item 5 - Did the SR authors perform study selection in duplicate? Yes
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AMSTAR Item 6 - Did the SR authors perform data extraction in duplicate, either independently or through verification? Yes
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AMSTAR Item 8 - Did the SR authors describe the included studies in adequate detail? Yes
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AMSTAR Item 9 - Did the SR authors use a satisfactory technique for assessing the risk of bias in individual studies that were included in the SR? Yes
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AMSTAR Item 12 - Did the SR authors assess the potential impact of risk of bias in individual studies on the summary results, interpretation, discussion? Yes
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AMSTAR Item 11 - If meta-analysis (MA) was performed did the SR authors use appropriate methods for statistical combination of results? Yes
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AMSTAR Item 14 - Did the SR authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the SR? Yes
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AMSTAR Item 16 - Did the SR authors report the lack of significant potential of conflict of interest (COI) regarding conducting the SR? Yes
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What was the OVERALL QUALITY OF THE SYSTEMATIC REVIEW High
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MATERNAL Adverse Events - ANTEPARTUM
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MATERNAL Adverse Events - POSTPARTUM
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MATERNAL Adverse Events - DELIVERY
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MATERNAL Adverse Events - TIMING NOT REPORTED
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FETAL/CHILD Adverse Events - IN UTERO
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FETAL/CHILD Adverse Events - PERINATAL
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FETAL/CHILD Adverse Events - NEONATAL
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7
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RR
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1.12
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0.79
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1.59
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NS
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  • Comments Comments (
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11
  • Comments Comments (
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RR
  • Comments Comments (
    0
    ) |
1.17
  • Comments Comments (
    0
    ) |
0.89
  • Comments Comments (
    0
    ) |
1.56
  • Comments Comments (
    0
    ) |
NS
  • Comments Comments (
    0
    ) |
16
  • Comments Comments (
    0
    ) |
RR
  • Comments Comments (
    0
    ) |
1.29
  • Comments Comments (
    0
    ) |
1.06
  • Comments Comments (
    0
    ) |
1.56
  • Comments Comments (
    0
    ) |
Intervention worse
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    0
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18
  • Comments Comments (
    0
    ) |
RR
  • Comments Comments (
    0
    ) |
1.36
  • Comments Comments (
    0
    ) |
1.08
  • Comments Comments (
    0
    ) |
1.71
  • Comments Comments (
    0
    ) |
Intervention worse
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15
  • Comments Comments (
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RR
  • Comments Comments (
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1.04
  • Comments Comments (
    0
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0.77
  • Comments Comments (
    0
    ) |
1.41
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    0
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NS
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17
  • Comments Comments (
    0
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RR
  • Comments Comments (
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1.14
  • Comments Comments (
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    ) |
0.97
  • Comments Comments (
    0
    ) |
1.35
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    0
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NS
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9
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RR
  • Comments Comments (
    0
    ) |
1.59
  • Comments Comments (
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    ) |
1.17
  • Comments Comments (
    0
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2.17
  • Comments Comments (
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Intervention worse
  • Comments Comments (
    0
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12
  • Comments Comments (
    0
    ) |
RR
  • Comments Comments (
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0.92
  • Comments Comments (
    0
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0.77
  • Comments Comments (
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1.08
  • Comments Comments (
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NS
  • Comments Comments (
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12
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RR
  • Comments Comments (
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1.12
  • Comments Comments (
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0.94
  • Comments Comments (
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1.34
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NS
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FETAL/CHILD Adverse Events - CHILD
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Baseline Characteristics
No baseline characteristics have been defined for this extraction form.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
No quality dimensions were specified.

Quality Rating
No quality rating data was found.