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Study Title and Description

Pregnancy Outcomes Following In Utero Exposure to Second-Generation Antipsychotics: A Systematic Review and Meta-Analysis.



Key Questions Addressed
4 Indirect Evidence (Systematic Reviews): KQ 2 - What are the (comparative) benefits and harms of interventions to treat acute attacks of primary headache in women who are pregnant (or attempting to become pregnant), postpartum, or breastfeeding?
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Primary Publication Information
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TitleData
Title Pregnancy Outcomes Following In Utero Exposure to Second-Generation Antipsychotics: A Systematic Review and Meta-Analysis.
Author Terrana N., Koren G., Pivovarov J., Etwel F., Nulman I.
Country From the *Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto; and †Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
Year 2015
Numbers Pubmed ID: 26274044

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Extraction Form for Indirect Evidence (Systematic Reviews)
Arms
No arms have been defined in this extraction form.

Design Details
Question... Follow Up Answer Follow-up Answer
How many DATABASES did the authors search? 2
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What was the YEAR of the last search? 2014
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How many STUDIES were included in the review? 12
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What INTERVENTIONS were addressed? Antipsychotics
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Any
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Were MATERNAL adverse events reported? No
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Were FETAL/CHILD adverse events reported? Yes
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AMSTAR Item 1 - Did the authors specify the research questions and inclusion criteria for the SR? Yes
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AMSTAR Item 4 - Did the SR authors use a comprehensive literature search strategy? Yes
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AMSTAR Item 5 - Did the SR authors perform study selection in duplicate? Unclear
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AMSTAR Item 6 - Did the SR authors perform data extraction in duplicate, either independently or through verification? Unclear
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AMSTAR Item 8 - Did the SR authors describe the included studies in adequate detail? Unclear
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AMSTAR Item 9 - Did the SR authors use a satisfactory technique for assessing the risk of bias in individual studies that were included in the SR? Yes
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AMSTAR Item 12 - Did the SR authors assess the potential impact of risk of bias in individual studies on the summary results, interpretation, discussion? Yes
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AMSTAR Item 11 - If meta-analysis (MA) was performed did the SR authors use appropriate methods for statistical combination of results? Yes
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AMSTAR Item 14 - Did the SR authors provide a satisfactory explanation for, and discussion of, any heterogeneity observed in the results of the SR? Yes
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AMSTAR Item 16 - Did the SR authors report the lack of significant potential of conflict of interest (COI) regarding conducting the SR? Yes
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What was the OVERALL QUALITY OF THE SYSTEMATIC REVIEW Moderate
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MATERNAL Adverse Events - ANTEPARTUM
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MATERNAL Adverse Events - POSTPARTUM
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MATERNAL Adverse Events - DELIVERY
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MATERNAL Adverse Events - TIMING NOT REPORTED
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FETAL/CHILD Adverse Events - IN UTERO
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NR
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OR
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1.10
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0.74
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1.64
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NS
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FETAL/CHILD Adverse Events - PERINATAL
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NR
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OR
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2.68
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0.56
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12.85
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NS
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OR
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1.58
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0.91
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2.74
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NS
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OR
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0.79
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0.22
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2.82
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NS
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FETAL/CHILD Adverse Events - NEONATAL
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FETAL/CHILD Adverse Events - CHILD
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Baseline Characteristics
No baseline characteristics have been defined for this extraction form.



Results & Comparisons

No Results found.
Adverse Events
Arm or Total Title Description Comments

Quality Dimensions
No quality dimensions were specified.

Quality Rating
No quality rating data was found.