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Study Title and Description

Comparison of pharmacological treatments for opioid-dependent adolescents: a randomized controlled trial.



Key Questions Addressed
1 Evidence map
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Primary Publication Information
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TitleData
Title Comparison of pharmacological treatments for opioid-dependent adolescents: a randomized controlled trial.
Author Marsch LA., Bickel WK., Badger GJ., Stothart ME., Quesnel KJ., Stanger C., Brooklyn J.
Country Department of Psychiatry, University of Vermont, Burlington, USA. marsch@ndri.org
Year 2005
Numbers Pubmed ID: 16203961

Secondary Publication Information
UI Title Author Country Year
Improvement in psychopathology among opioid-dependent adolescents during behavioral-pharmacological treatment. Moore SK., Marsch LA., Badger GJ., Solhkhah R., Hofstein Y. National Development and Research Institutes, Inc, New York, NY 10010, USA. Moore@ndri.org 2011
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Extraction Form: Evidence Map
Arms
Number Title Description Comments
1 Buprenorphine_CBT_CM buprenorphine
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2 Clonidine_CBT_CM clonidine
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Design Details
Question... Follow Up Answer Follow-up Answer
Should this citation be included? Yes
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Does this paper originate from a primary study of interest? No
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Ages eligible (in years) 13
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18
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Total sample size (in all arms) 36
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Age distribution of enrolled population (in years) 17.4
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Substance used Opioid
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Interventions studied? Combined behavioral and pharmacologic
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Outcome? Objective measurement of use/abstinence and/or intensity
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Self report of use/abstinence and/or intensity
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Substance-related problems or symptoms scale
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School or Educational
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Physical health
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Adverse effects
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Age variation of enrolled population (in years) 0.7
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Study type RCT
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Is any arm a brief intervention (or single session)? No
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Income level of country(ies) of origin Upper income
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Results & Comparisons

No Results found.

Quality Dimensions
Dimension Value Notes Comments
Intention-to-treat-analysis: Bias due to incomplete reporting and analysis according to group allocation Yes
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Group similarity at baseline (selection bias): Selection bias due to dissimilarity at baseline for the most important prognostic indicators Yes
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Co-interventions (performance bias): Performance bias because co-interventions were different across groups Yes
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Compliance (performance bias): Performance bias due to inappropriate compliance with interventions across groups No 72% (buprenorphine) vs. 39% (clonidine)
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Timing of outcome assessments (detection bias): Detection bias because important outcomes were not measured at the same time across groups Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. If yes, describe them in the Notes. No
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Random sequence generation (selection bias): Selection bias (biased allocation to interventions) due to inadequate generation of a randomized sequence Unclear
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Allocation concealment (selection bias): Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment Unclear
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Blinding of participants (performance bias): Performance bias due to knowledge of the allocated interventions by participants during the study Low
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Blinding of personnel/ care providers (performance bias): Performance bias due to knowledge of the allocated interventions by personnel/care providers during the study. Low
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Blinding of outcome assessor (detection bias): Detection bias due to knowledge of the allocated interventions by outcome assessors. Low
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Incomplete outcome data (attrition bias): Attrition bias due to amount, nature or handling of incomplete outcome data Unclear No data
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Selective Reporting (reporting bias): Reporting bias due to selective outcome reporting
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Quality Rating
No quality rating data was found.