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Study Title and Description

Treating adolescent drug abuse: a randomized trial comparing multidimensional family therapy and cognitive behavior therapy.



Key Questions Addressed
1 Evidence map
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Primary Publication Information
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TitleData
Title Treating adolescent drug abuse: a randomized trial comparing multidimensional family therapy and cognitive behavior therapy.
Author Liddle HA., Dakof GA., Turner RM., Henderson CE., Greenbaum PE.
Country Center for Treatment Research on Adolescent Drug Abuse, Department of Epidemiology and Public Health, 1120 NW 14th Street, Miami, 33136, University of Miami Miller School of Medicine, Miami, FL 33136, USA. hliddle@med.miami.edu
Year 2008
Numbers Pubmed ID: 18705691

Secondary Publication Information
UI Title Author Country Year
Gender and ethnicity as moderators: Integrative data analysis of multidimensional family therapy randomized clinical trials. Greenbaum PE., Wang W., Henderson CE., Kan L., Hall K., Dakof GA., Liddle HA. Department of Child and Family Studies, College of Behavioral and Community Science, University of South Florida. 2015
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Effectiveness of multidimensional family therapy with higher severity substance-abusing adolescents: report from two randomized controlled trials. Henderson CE., Dakof GA., Greenbaum PE., Liddle HA. Department of Psychology, Sam Houston State University, Huntsville, TX 77341, USA. chenderson@shsu.edu 2010
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LINKING SESSION FOCUS TO TREATMENT OUTCOME IN EVIDENCE-BASED TREATMENTS FOR ADOLESCENT SUBSTANCE ABUSE. Hogue A., Dauber S., Liddle HA., Samuolis J. National Center on Addiction and Substance Abuse at Columbia University. 2004
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Treatment adherence, competence, and outcome in individual and family therapy for adolescent behavior problems. Hogue A., Henderson CE., Dauber S., Barajas PC., Fried A., Liddle HA. Health and Treatment Research, National Center on Addiction and Substance Abuse at Columbia University, 633 Third Avenue, 19th floor, New York, NY 10017, USA. ahogue@casacolumbia.org 2008
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Extraction Form: Evidence Map
Arms
Number Title Description Comments
1 Fam MFT
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2 CBT
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Design Details
Question... Follow Up Answer Follow-up Answer
Should this citation be included? Yes
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Does this paper originate from a primary study of interest? No
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Ages eligible (in years) 12
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17.5
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Total sample size (in all arms) 224
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Age distribution of enrolled population (in years) 15.3
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Substance used Alcohol
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Cannabis
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Interventions studied? Behavioral
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Outcome? Objective measurement of use/abstinence and/or intensity
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Self report of use/abstinence and/or intensity
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Age variation of enrolled population (in years) 1.25
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Study type RCT
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Is any arm a brief intervention (or single session)? No
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Income level of country(ies) of origin ... Country(ies) name(s) Unclear ... United States
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Results & Comparisons


Results Data
Outcome: alcohol use days      Population: All Participants
Time Point Measure Fam CBT


0 months

Mean 28.47 27.41
SD 17.36 15.65
N Analyzed 112 112


5 months

Mean 19.75 27.39
SD 18.18 19.71
N Analyzed 112 112


6 months

Mean 18.88 20.35
SD 17.86 18.73
N Analyzed 112 112


12 months

Mean 11.66 19.43
SD 17.67 20.3
N Analyzed 112 112
Outcome: cannabis use days      Population: All Participants
Time Point Measure Fam CBT


0 months

Mean 10.41 11.89
SD 11.38 12.71
N Analyzed 112 112


5 months

Mean 5.12 9.83
SD 8.3 15.56
N Analyzed 112 112


6 months

Mean 5.77 6.74
SD 8.58 11.95
N Analyzed 112 112


12 months

Mean 4.3 6.41
SD 10.15 11.23
N Analyzed 112 112
Outcome: PEI      Population: All Participants
Time Point Measure Fam CBT


0 months

Mean 28.47 27.41
SD 17.36 15.65
N Analyzed 112 113


5 months

Mean 19.75 27.39
SD 18.18 19.71
N Analyzed 112 113


6 months

Mean 18.88 20.35
SD 17.86 18.73
N Analyzed 112 113


12 months

Mean 11.66 19.43
SD 17.67 20.3
N Analyzed 112 113
Outcome: nos use days      Population: All Participants
Time Point Measure Fam CBT


0 months

Mean 1.63 0.52
SD 5.07 1.41
N Analyzed 112 112


5 months

Mean 0.55 1.43
SD 2.31 5.97
N Analyzed 65 59


6 months

Mean 0.37 0.32
SD 1.56 1.54
N Analyzed 67 53


12 months

Mean 0.14 1.0
SD 0.65 4.0
N Analyzed 73 63


Quality Dimensions
Dimension Value Notes Comments
Intention-to-treat-analysis: Bias due to incomplete reporting and analysis according to group allocation Yes
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Group similarity at baseline (selection bias): Selection bias due to dissimilarity at baseline for the most important prognostic indicators Yes
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Co-interventions (performance bias): Performance bias because co-interventions were different across groups Yes
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Compliance (performance bias): Performance bias due to inappropriate compliance with interventions across groups Unsure Assessed only on a random subset of patients
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Timing of outcome assessments (detection bias): Detection bias because important outcomes were not measured at the same time across groups Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. If yes, describe them in the Notes. No
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Random sequence generation (selection bias): Selection bias (biased allocation to interventions) due to inadequate generation of a randomized sequence Unclear
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Allocation concealment (selection bias): Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment Low
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Blinding of participants (performance bias): Performance bias due to knowledge of the allocated interventions by participants during the study High
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Blinding of personnel/ care providers (performance bias): Performance bias due to knowledge of the allocated interventions by personnel/care providers during the study. High
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Blinding of outcome assessor (detection bias): Detection bias due to knowledge of the allocated interventions by outcome assessors. Low
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Incomplete outcome data (attrition bias): Attrition bias due to amount, nature or handling of incomplete outcome data High
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Selective Reporting (reporting bias): Reporting bias due to selective outcome reporting
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Quality Rating
No quality rating data was found.