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Study Title and Description

Multidimensional Family Therapy as a community-based alternative to residential treatment for adolescents with substance use and co-occurring mental health disorders.



Key Questions Addressed
1 Evidence map
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Primary Publication Information
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TitleData
Title Multidimensional Family Therapy as a community-based alternative to residential treatment for adolescents with substance use and co-occurring mental health disorders.
Author Liddle HA., Dakof GA., Rowe CL., Henderson C., Greenbaum P., Wang W., Alberga L.
Country University of Miami Miller School of Medicine, Miami, FL, USA.
Year 2018
Numbers Pubmed ID: 29866383

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Evidence Map
Arms
Number Title Description Comments
1 TAU RT
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2 Fam MDFT
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Design Details
Question... Follow Up Answer Follow-up Answer
Should this citation be included? Yes
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Does this paper originate from a primary study of interest? No
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Ages eligible (in years) 13
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18
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Total sample size (in all arms) 113
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Age distribution of enrolled population (in years) 15.38
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Substance used Alcohol
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Cannabis
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Opioid
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Stimulant
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Interventions studied? Behavioral
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Outcome? Objective measurement of use/abstinence and/or intensity
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Self report of use/abstinence and/or intensity
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Other ... delinquent behaviors
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Age variation of enrolled population (in years) 1.12
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Study type RCT
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Is any arm a brief intervention (or single session)? No
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Income level of country(ies) of origin ... Country(ies) name(s) Unclear ... United States
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Results & Comparisons


Results Data
Outcome: PEI      Population: All Participants
Time Point Measure TAU Fam


0 months

N Analyzed 56 57
Mean 63.95 61.25
SD 24.24 20.94


2 months

N Analyzed 55 57
Mean 35.44 40.96
SD 10.24 12.81


4 months

N Analyzed 53 55
Mean 38.10 39.57
SD 14.83 12.02


12 months

N Analyzed 50 54
Mean 41.82 39.20
SD 17.59 14.74


18 months

N Analyzed 49 54
Mean 41.43 39.21
SD 14.66 12.69
Outcome: YSR      Population: 122310
Time Point Measure TAU Fam


0 months

N Analyzed 56 57
Mean 59.18 60.17
SD 14.73 13.40


2 months

N Analyzed 55 57
Mean 53.20 51.26
SD 12.09 9.23


4 months

N Analyzed 53 55
Mean 52.28 53.10
SD 10.80 11.25


12 months

N Analyzed 50 54
Mean 49.90 49.26
SD 9.34 11.28


18 months

N Analyzed 49 54
Mean 51.04 49.03
SD 8.77 10.92
Outcome: YSR      Population: 122311
Time Point Measure TAU Fam


0 months

N Analyzed 56 57
Mean 50.63 51.59
SD 13.17 11.82


2 months

N Analyzed 55 57
Mean 49.63 46.13
SD 10.95 8.28


4 months

N Analyzed 53 55
Mean 49.14 48.07
SD 12.84 10.98


12 months

N Analyzed 50 54
Mean 48.45 45.72
SD 10.67 8.87


18 months

N Analyzed 49 54
Mean 47.04 45.96
SD 9.57 9.79
Outcome: nos use days      Population: All Participants
Time Point Measure TAU Fam


0 months

N Analyzed 56 57
Mean 27.57 33.40
SD 18.01 19.05


2 months

N Analyzed 55 57
Mean 3.04 6.75
SD 6.69 10.39


4 months

N Analyzed 53 55
Mean 5.07 5.31
SD 10.70 7.74


12 months

N Analyzed 50 54
Mean 9.77 8.75
SD 13.98 13.83


18 months

N Analyzed 49 54
Mean 9.51 8.89
SD 14.10 12.24
Outcome: SRD      Population: All Participants
Time Point Measure TAU Fam


0 months

N Analyzed 56 57
SD 1.28 1.40
Log Mean 1.65 1.15


2 months

N Analyzed 55 57
SD 1.25 1.10
Log Mean 0.99 0.99


4 months

N Analyzed 53 55
SD 0.98 1.22
Log Mean 0.66 1.08


12 months

N Analyzed 50 54
SD 1.12 0.97
Log Mean 0.69 0.60


18 months

N Analyzed 49 54
SD 1.10 1.00
Log Mean 0.75 0.55


Quality Dimensions
Dimension Value Notes Comments
Intention-to-treat-analysis: Bias due to incomplete reporting and analysis according to group allocation Yes
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Group similarity at baseline (selection bias): Selection bias due to dissimilarity at baseline for the most important prognostic indicators Yes
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Co-interventions (performance bias): Performance bias because co-interventions were different across groups Yes
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Compliance (performance bias): Performance bias due to inappropriate compliance with interventions across groups No High rate in ATP arm of low attendance.
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Timing of outcome assessments (detection bias): Detection bias because important outcomes were not measured at the same time across groups Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. If yes, describe them in the Notes. No
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Random sequence generation (selection bias): Selection bias (biased allocation to interventions) due to inadequate generation of a randomized sequence Low Urn, N>100
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Allocation concealment (selection bias): Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment Unclear
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Blinding of participants (performance bias): Performance bias due to knowledge of the allocated interventions by participants during the study High
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Blinding of personnel/ care providers (performance bias): Performance bias due to knowledge of the allocated interventions by personnel/care providers during the study. High
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Blinding of outcome assessor (detection bias): Detection bias due to knowledge of the allocated interventions by outcome assessors. High Very unlikely (residential vs. nonresidential interventions)
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Incomplete outcome data (attrition bias): Attrition bias due to amount, nature or handling of incomplete outcome data Low
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Selective Reporting (reporting bias): Reporting bias due to selective outcome reporting
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Quality Rating
Guideline Used Overall Rating