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Study Title and Description

Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings.



Key Questions Addressed
1 Evidence map
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Primary Publication Information
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TitleData
Title Multidimensional family therapy lowers the rate of cannabis dependence in adolescents: a randomised controlled trial in Western European outpatient settings.
Author Rigter H., Henderson CE., Pelc I., Tossmann P., Phan O., Hendriks V., Schaub M., Rowe CL.
Country Department of Public Health, Erasmus MC, 3000 CA Rotterdam, The Netherlands. rigter.h@kpnmail.nl
Year 2013
Numbers Pubmed ID: 23140805

Secondary Publication Information
UI Title Author Country Year
Multidimensional family therapy in adolescents with a cannabis use disorder: long-term effects on delinquency in a randomized controlled trial. van der Pol TM., Hendriks V., Rigter H., Cohn MD., Doreleijers TAH., van Domburgh L., Vermeiren RRJM. 1Department of Child and Adolescent Psychiatry, Curium-Leiden University Medical Center, Leiden, The Netherlands. 2018
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Treatment of adolescents with a cannabis use disorder: main findings of a randomized controlled trial comparing multidimensional family therapy and cognitive behavioral therapy in The Netherlands. Hendriks V., van der Schee E., Blanken P. Parnassia Addiction Research Centre (PARC), Brijder Addiction Treatment, Parnassia Bavo Group, The Hague, The Netherlands. vincent.hendriks@brijder.nl 2011
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Matching adolescents with a cannabis use disorder to multidimensional family therapy or cognitive behavioral therapy: treatment effect moderators in a randomized controlled trial. Hendriks V., van der Schee E., Blanken P. Parnassia Addiction Research Centre, Brijder Addiction Treatment, Parnassia Bavo Group, PO-Box 53002, 2505 AA, The Hague, The Netherlands. vincent.hendriks@brijder.nl 2012
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Multidimensional family therapy and cognitive behavioral therapy in adolescents with a cannabis use disorder: a randomised controlled study. Hendriks VM., van der Schee E., Blanken P. -- Not Found -- 2013
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Effectiveness of formalised therapy for adolescents with cannabis dependence: A randomised trial Lascaux 2016
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Multidimensional family therapy decreases the rate of externalising behavioural disorder symptoms in cannabis abusing adolescents: outcomes of the INCANT trial. Schaub MP., Henderson CE., Pelc I., Tossmann P., Phan O., Hendriks V., Rowe C., Rigter H. Swiss Research Institute for Public Health and Addiction, associated to University of Zurich, Zurich, Switzerland. michael.schaub@isgf.uzh.ch. 2014
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Multidimensionale Familientherapie (MDFT) bei cannabisbezogenen Störungen. = Treating adolescents with cannabis use disorder with multidimensional family therapy (MDFT): Main results of a randomized controlled trial (RCT) Tossmann 2012
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Extraction Form: Evidence Map
Arms
Number Title Description Comments
1 TAU Individual psychotherapy
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2 Fam Multidimensional family therapy
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Design Details
Question... Follow Up Answer Follow-up Answer
Should this citation be included? Yes
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Does this paper originate from a primary study of interest? No
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Ages eligible (in years) 13
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18
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Total sample size (in all arms) 450
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Age distribution of enrolled population (in years) 16.3
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Substance used Cannabis
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Interventions studied? Behavioral
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Outcome? Objective measurement of use/abstinence and/or intensity
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Self report of use/abstinence and/or intensity
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Age variation of enrolled population (in years) NA
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Study type RCT
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Is any arm a brief intervention (or single session)? No
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Income level of country(ies) of origin ... Country(ies) name(s) Unclear ... Netherlands
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Results & Comparisons


Results Data
Outcome: cannabis dep sxs      Population: All Participants
Time Point Measure TAU Fam


0 months

N Analyzed 238 212
Counts 195 173


12 months

N Analyzed 211 190
Counts 124 81
Outcome: cannabis use days      Population: All Participants
Time Point Measure TAU Fam


0 months

Mean 59.8 61.5
SD 25.3 25.4
N Analyzed 238 212


3 months

Mean 39.4 45.2
SD 32.5 30.2
N Analyzed 238 212


6 months

Mean 33.9 41.8
SD 31.9 31.6
N Analyzed 238 212


9 months

Mean 35 40.8
SD 33.5 32
N Analyzed 238 212


12 months

Mean 34 42.3
SD 32.6 33.8
N Analyzed 211 190


Quality Dimensions
Dimension Value Notes Comments
Intention-to-treat-analysis: Bias due to incomplete reporting and analysis according to group allocation Yes
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Group similarity at baseline (selection bias): Selection bias due to dissimilarity at baseline for the most important prognostic indicators Yes Per Schaub-2014-24485347
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Co-interventions (performance bias): Performance bias because co-interventions were different across groups Yes
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Compliance (performance bias): Performance bias due to inappropriate compliance with interventions across groups No MDFT 90%; IP 48%
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Timing of outcome assessments (detection bias): Detection bias because important outcomes were not measured at the same time across groups Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. If yes, describe them in the Notes. No
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Random sequence generation (selection bias): Selection bias (biased allocation to interventions) due to inadequate generation of a randomized sequence Unclear
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Allocation concealment (selection bias): Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment Low
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Blinding of participants (performance bias): Performance bias due to knowledge of the allocated interventions by participants during the study High
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Blinding of personnel/ care providers (performance bias): Performance bias due to knowledge of the allocated interventions by personnel/care providers during the study. High
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Blinding of outcome assessor (detection bias): Detection bias due to knowledge of the allocated interventions by outcome assessors. Low Research staff blinded
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Incomplete outcome data (attrition bias): Attrition bias due to amount, nature or handling of incomplete outcome data Low 11%
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Selective Reporting (reporting bias): Reporting bias due to selective outcome reporting need to check Per Protocol (Rigter-2010-20380718): Cannabis use, other SUD (ADI-Light, TLFB); Personal Experiences Inventory; Urine analysis, Youth Self Report (internalizing, externalizing, and psychotic symptoms); Child Behavior Checklist; Family Environment Scale; Satisfaction Scale
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Quality Rating
No quality rating data was found.