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Study Title and Description

The efficacy of two adolescent substance abuse treatments and the impact of comorbid depression: results of a small randomized controlled trial.



Key Questions Addressed
1 Evidence map
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Primary Publication Information
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TitleData
Title The efficacy of two adolescent substance abuse treatments and the impact of comorbid depression: results of a small randomized controlled trial.
Author Santisteban DA., Mena MP., Muir J., McCabe BE., Abalo C., Cummings AM.
Country Department of Educational and Psychological Studies, School of Education and Human Development, University of Miami.
Year 2015
Numbers Pubmed ID: 25799306

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Evidence Map
Arms
Number Title Description Comments
1 CBT_Fam Integrative borderline personality disorder-oriented Adolescent Family Therapy (I-BAFT)
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2 TAU Individual Drug Counseling (IDC)
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Design Details
Question... Follow Up Answer Follow-up Answer
Should this citation be included? Yes
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Does this paper originate from a primary study of interest? No
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Ages eligible (in years) 14
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17
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Total sample size (in all arms) 40
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Age distribution of enrolled population (in years) 16
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Substance used Alcohol
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Cannabis
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Opioid
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Stimulant
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Interventions studied? Behavioral
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Outcome? Objective measurement of use/abstinence and/or intensity
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Self report of use/abstinence and/or intensity
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Other ... Depressive symptoms, borderline personality disorder behaviors
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Age variation of enrolled population (in years) 0.8
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Study type RCT
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Is any arm a brief intervention (or single session)? No
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Income level of country(ies) of origin ... Country(ies) name(s) Unclear ... United States
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Results & Comparisons


Results Data
Outcome: pct abstinent for nos      Population: All Participants
Time Point Measure CBT_Fam TAU


12 months

N Analyzed
Counts
Percentage
Outcome: pct abstinent for nos      Population: without comorbid depression
Time Point Measure CBT_Fam TAU


12 months

N Analyzed 13 12
Counts
Percentage 10 21
Outcome: pct abstinent for nos      Population: with comorbid depression
Time Point Measure CBT_Fam TAU


12 months

N Analyzed 7 8
Counts
Percentage 60 11
Outcome: Psychiatric outcome      Population: without comorbid depression
Time Point Measure CBT_Fam TAU


12 months

N Analyzed 13 12
Counts
Percentage 56 53
Outcome: Psychiatric outcome      Population: with comorbid depression
Time Point Measure CBT_Fam TAU


12 months

N Analyzed 7 8
Counts
Percentage 48 70


Quality Dimensions
Dimension Value Notes Comments
Intention-to-treat-analysis: Bias due to incomplete reporting and analysis according to group allocation No
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Group similarity at baseline (selection bias): Selection bias due to dissimilarity at baseline for the most important prognostic indicators Yes
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Co-interventions (performance bias): Performance bias because co-interventions were different across groups Yes
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Compliance (performance bias): Performance bias due to inappropriate compliance with interventions across groups No Data
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Timing of outcome assessments (detection bias): Detection bias because important outcomes were not measured at the same time across groups Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. If yes, describe them in the Notes. No
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Random sequence generation (selection bias): Selection bias (biased allocation to interventions) due to inadequate generation of a randomized sequence Unclear
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Allocation concealment (selection bias): Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment Unclear
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Blinding of participants (performance bias): Performance bias due to knowledge of the allocated interventions by participants during the study High
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Blinding of personnel/ care providers (performance bias): Performance bias due to knowledge of the allocated interventions by personnel/care providers during the study. High
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Blinding of outcome assessor (detection bias): Detection bias due to knowledge of the allocated interventions by outcome assessors. High
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Incomplete outcome data (attrition bias): Attrition bias due to amount, nature or handling of incomplete outcome data Low Used multiple imputation to account for missing data.
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Selective Reporting (reporting bias): Reporting bias due to selective outcome reporting
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Quality Rating
No quality rating data was found.