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Study Title and Description

Early intervention for adolescent substance abuse: pretreatment to posttreatment outcomes of a randomized clinical trial comparing multidimensional family therapy and peer group treatment.



Key Questions Addressed
1 Evidence map
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Primary Publication Information
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TitleData
Title Early intervention for adolescent substance abuse: pretreatment to posttreatment outcomes of a randomized clinical trial comparing multidimensional family therapy and peer group treatment.
Author Liddle HA., Rowe CL., Dakof GA., Ungaro RA., Henderson CE.
Country Center for Treatment Research on Adolescent Drug Abuse, Department of Epidemiology and Public Health, University of Miami School of Medicine, Miami, Florida 33101, USA. hliddle@med.miami.edu
Year 2004
Numbers Pubmed ID: 15152709

Secondary Publication Information
UI Title Author Country Year
Parenting practices as mediators of treatment effects in an early-intervention trial of multidimensional family therapy. Henderson CE., Rowe CL., Dakof GA., Hawes SW., Liddle HA. Department of Psychology, Sam Houston State University, Huntsville, Texas 77341-2247, USA. 2009
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Multidimensional family therapy for young adolescent substance abuse: twelve-month outcomes of a randomized controlled trial. Liddle HA., Rowe CL., Dakof GA., Henderson CE., Greenbaum PE. Center for Treatment Research on Adolescent Drug Abuse, Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, 1120 NW 14th Street, Miami, FL 33136, USA. HLiddle@med.miami.edu 2009
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Extraction Form: Evidence Map
Arms
Number Title Description Comments
1 Fam Multidimensional family therapy
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2 CBT Peer group
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Design Details
Question... Follow Up Answer Follow-up Answer
Should this citation be included? Yes
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Does this paper originate from a primary study of interest? No
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Ages eligible (in years) 11
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15
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Total sample size (in all arms) 80
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Age distribution of enrolled population (in years) 14
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Substance used SUD (not further described, except maybe excluding nicotine)
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Interventions studied? Behavioral
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Outcome? Objective measurement of use/abstinence and/or intensity
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Self report of use/abstinence and/or intensity
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Substance-related problems or symptoms scale
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School or Educational
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Family functioning
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Peer functioning
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Age variation of enrolled population (in years) 1.1
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Study type RCT
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Is any arm a brief intervention (or single session)? No
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Income level of country(ies) of origin ... Country(ies) name(s) Unclear ... United States
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Results & Comparisons


Results Data
Outcome: pct abstinent for cannabis      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Counts 22 12
Percentage 55 28


1.5 months

N Analyzed 40 43
Counts 31 21
Percentage 78 51


3.5 months

N Analyzed 40 43
Counts 36 21
Percentage 90 51


6 months

N Analyzed 40 43
Counts 33 16
Percentage 83 39


12 months

N Analyzed 40 43
Counts 34 19
Percentage 85 45
Outcome: cannabis abuse sxs      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Counts 20 22
Percentage 50 51


1.5 months

N Analyzed 40 43
Counts 5 17
Percentage 12 40


3.5 months

N Analyzed 40 43
Counts 6 12
Percentage 15 28


6 months

N Analyzed 40 43
Counts 4 14
Percentage 10 33


12 months

N Analyzed 40 43
Counts 7 15
Percentage 18 35
Outcome: Illegal behavior      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Counts 19 22
Percentage 48 51


1.5 months

N Analyzed 40 43
Counts 4 14
Percentage 10 33


3.5 months

N Analyzed 40 43
Counts 6 14
Percentage 15 33


6 months

N Analyzed 40 43
Counts 11 13
Percentage 28 30


12 months

N Analyzed 40 43
Counts 9 14
Percentage 23 33
Outcome: cannabis use days      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Mean 3.05 4.21
SD 5.65 4.84
SE


1.5 months

N Analyzed 40 43
Mean 0.62 2.95
SD 1.80 5.62
SE


3.5 months

N Analyzed 40 43
Mean 0.68 4.31
SD 3.64 7.11
SE


6 months

N Analyzed 40 43
Mean 0.87 2.66
SD 3.72 3.64
SE


12 months

N Analyzed 40 43
Mean 0.23 2.55
SD 0.74 3.22
SE
Outcome: Family      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Mean 13.83 13.75
SD 2.07 2.23
SE


1.5 months

N Analyzed 40 43
Mean 14.36 15.03
SD 2.34 2.04
SE


3.5 months

N Analyzed 40 43
Mean 14.26 15.17
SD 2.18 2.02
SE


6 months

N Analyzed 40 43
Mean 14.85 15.07
SD 2.36 2.28
SE


12 months

N Analyzed 40 43
Mean 15.16 14.88
SD 2.01 2.31
SE
Outcome: Family      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Mean 7.33 7.15
SD 1.15 0.90
SE


1.5 months

N Analyzed 40 43
Mean 7.46 7.30
SD 0.75 0.88
SE


3.5 months

N Analyzed 40 43
Mean 7.38 7.60
SD 0.74 0.65
SE


6 months

N Analyzed 40 43
Mean 7.43 7.61
SD 0.78 0.60
SE


12 months

N Analyzed 40 43
Mean 7.53 7.69
SD 0.72 0.52
SE
Outcome: Peer      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 40 43
Mean 99.07 100.26
SD 15.90 15.45
SE


1.5 months

N Analyzed 40 43
Mean 112.28 114.67
SD 12.38 14.11
SE


3.5 months

N Analyzed 40 43
Mean 113.11 105.23
SD 4.80 14.52
SE


6 months

N Analyzed 40 43
Mean 113.50 109.52
SD 3.47 9.57
SE


12 months

N Analyzed 40 43
Mean 112.56 106.27
SD 8.13 20.14
SE
Outcome: cannabis abuse sxs      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 41 39
Mean 56.61 54.67
SD 12.65 13.39
SE


1.5 months

N Analyzed 41 39
Mean 47.90 50.98
SD 9.57 11.40
SE


3.5 months

N Analyzed 41 39
Mean 44.72 48.90
SD 7.35 9.21
SE


6 months

N Analyzed
Mean
SD
SE


12 months

N Analyzed
Mean
SD
SE
Outcome: cannabis abuse sxs      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 41 39
Mean 52.15 50.18
SD 14.62 13.21
SE


1.5 months

N Analyzed 41 39
Mean 44.57 47.68
SD 7.08 12.00
SE


3.5 months

N Analyzed 41 39
Mean 42.70 45.65
SD 8.71 8.64
SE


6 months

N Analyzed
Mean
SD
SE


12 months

N Analyzed
Mean
SD
SE
Outcome: Family      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 41 39
Mean 11.89 11.24
SD 2.39 1.67
SE


1.5 months

N Analyzed 41 39
Mean 11.02 11.17
SD 2.11 2.02
SE


3.5 months

N Analyzed 41 39
Mean 10.94 11.54
SD 1.91 2.15
SE


6 months

N Analyzed
Mean
SD
SE


12 months

N Analyzed
Mean
SD
SE
Outcome: Family      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 41 39
Mean 14.53 11.24
SD 2.01 1.67
SE


1.5 months

N Analyzed 41 39
Mean 15.26 11.17
SD 2.05 2.02
SE


3.5 months

N Analyzed 41 39
Mean 15.20 11.54
SD 2.24 2.15
SE


6 months

N Analyzed
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SD
SE


12 months

N Analyzed
Mean
SD
SE
Outcome: School      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 41 39
Mean 5.71 5.38
SD 1.31 1.19
SE


1.5 months

N Analyzed 41 39
Mean 5.18 5.33
SD 1.13 1.25
SE


3.5 months

N Analyzed 41 39
Mean 4.86 4.78
SD 1.03 1.07
SE


6 months

N Analyzed
Mean
SD
SE


12 months

N Analyzed
Mean
SD
SE
Outcome: School      Population: All Participants
Time Point Measure Fam CBT


0 months

N Analyzed 41 39
Mean 8.37 8.18
SD 1.81 1.87
SE


1.5 months

N Analyzed 41 39
Mean 7.33 7.53
SD 1.53 1.37
SE


3.5 months

N Analyzed 41 39
Mean 7.09 7.58
SD 1.29 1.55
SE


6 months

N Analyzed
Mean
SD
SE


12 months

N Analyzed
Mean
SD
SE


Quality Dimensions
Dimension Value Notes Comments
Intention-to-treat-analysis: Bias due to incomplete reporting and analysis according to group allocation Yes
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Group similarity at baseline (selection bias): Selection bias due to dissimilarity at baseline for the most important prognostic indicators Yes
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Co-interventions (performance bias): Performance bias because co-interventions were different across groups Yes
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Compliance (performance bias): Performance bias due to inappropriate compliance with interventions across groups No MDFT clients completed treatment at a higher rate than group clients
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Timing of outcome assessments (detection bias): Detection bias because important outcomes were not measured at the same time across groups Yes
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Additional Bias: Bias due to problems not covered elsewhere in the table. If yes, describe them in the Notes. No
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Random sequence generation (selection bias): Selection bias (biased allocation to interventions) due to inadequate generation of a randomized sequence Low Urn (Liddle-2009-19170450)
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Allocation concealment (selection bias): Selection bias (biased allocation to interventions) due to inadequate concealment of allocations prior to assignment Unclear
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Blinding of participants (performance bias): Performance bias due to knowledge of the allocated interventions by participants during the study High
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Blinding of personnel/ care providers (performance bias): Performance bias due to knowledge of the allocated interventions by personnel/care providers during the study. High
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Blinding of outcome assessor (detection bias): Detection bias due to knowledge of the allocated interventions by outcome assessors. Low
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Incomplete outcome data (attrition bias): Attrition bias due to amount, nature or handling of incomplete outcome data Low 97% complete (Liddle-2009-19170450)
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Selective Reporting (reporting bias): Reporting bias due to selective outcome reporting
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Quality Rating
Guideline Used Overall Rating