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Project: Skin Substitutes for Treating Chronic Wounds

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Title Created by Key Questions Addressed Form Notes
Design and data David Snyder 1


Associated Studies (each link opens a new tab)

Title Author Year
Diabetic Foot Ulcers Treated With Porcine Urinary Bladder Extracellular Matrix and Total Contact Cast: Interim Analysis of a Randomized, Controlled Trial. Alvarez OM., Smith T., Gilbert TW., Onumah NJ., Wendelken ME., Parker R., Markowitz L. 2017
Venous Ulcers Treated With a Hyaluronic Acid Extracellular Matrix and Compression Therapy: Interim Analysis of a Randomized Controlled Trial. Alvarez OM., Makowitz L., Patel M. 2017
A multicenter, randomized, single-blind trial comparing the efficacy of viable cryopreserved placental membrane to human fibroblast-derived dermal substitute for the treatment of chronic diabetic foot ulcers. Ananian CE., Dhillon YS., Van Gils CC., Lindsey DC., Otto RJ., Dove CR., Pierce JT., Saunders MC. 2018
A multicentre randomised controlled trial evaluating the efficacy of dehydrated human amnion/chorion membrane (EpiFix Bianchi C., Cazzell S., Vayser D., Reyzelman AM., Dosluoglu H., Tovmassian G. 2018
An extracellular matrix graft (Oasis wound matrix) for treating full-thickness pressure ulcers: a randomized clinical trial. Brown-Etris M., Milne CT., Hodde JP. 2019
A Randomized Controlled Trial Comparing a Human Acellular Dermal Matrix Versus Conventional Care for the Treatment of Venous Leg Ulcers. Cazzell S. 2019
A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator. Cazzell S., Vayser D., Pham H., Walters J., Reyzelman A., Samsell B., Dorsch K., Moore M. 2017
Use of an aseptically processed, dehydrated human amnion and chorion membrane improves likelihood and rate of healing in chronic diabetic foot ulcers: A prospective, randomised, multi-centre clinical trial in 80 patients. DiDomenico LA., Orgill DP., Galiano RD., Serena TE., Carter MJ., Kaufman JP., Young NJ., Jacobs AM., Zelen CM. 2018
A clinical trial of Integra Template for diabetic foot ulcer treatment. Driver VR., Lavery LA., Reyzelman AM., Dutra TG., Dove CR., Kotsis SV., Kim HM., Chung KC. -- Not Found --
Evaluation of tissue engineering products for the management of neuropathic diabetic foot ulcers: an interim analysis. Frykberg RG., Cazzell SM., Arroyo-Rivera J., Tallis A., Reyzelman AM., Saba F., Warren L., Stouch BC., Gilbert TW. 2016
A prospective, multicentre, randomised controlled study of human fibroblast-derived dermal substitute (Dermagraft) in patients with venous leg ulcers. Harding K., Sumner M., Cardinal M. 2013
The efficacy and safety of Grafix(®) for the treatment of chronic diabetic foot ulcers: results of a multi-centre, controlled, randomised, blinded, clinical trial. Lavery LA., Fulmer J., Shebetka KA., Regulski M., Vayser D., Fried D., Kashefsky H., Owings TM., Nadarajah J. 2014
A prospective, multicenter, randomized, controlled clinical trial comparing a bioengineered skin substitute to a human skin allograft. Sanders L., Landsman AS., Landsman A., Keller N., Cook J., Cook E., Hopson M. 2014
A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment of venous leg ulcers. Serena TE., Carter MJ., Le LT., Sabo MJ., DiMarco DT. 2014
A prospective multicenter randomized controlled clinical trial of a hypothermically stored amniotic membrane for the management of diabetic foot ulcers [manuscript]. Serena TE, Yaakov R, Moore S, et al. 2019
A Prospective, Randomized, Multicenter, Controlled Evaluation of the Use of Dehydrated Amniotic Membrane Allograft Compared to Standard of Care for the Closure of Chronic Diabetic Foot Ulcer. Snyder RJ., Shimozaki K., Tallis A., Kerzner M., Reyzelman A., Lintzeris D., Bell D., Rutan RL., Rosenblum B. 2016
A confirmatory study on the efficacy of dehydrated human amnion/chorion membrane dHACM allograft in the management of diabetic foot ulcers: A prospective, multicentre, randomised, controlled study of 110 patients from 14 wound clinics. Tettelbach W., Cazzell S., Reyzelman AM., Sigal F., Caporusso JM., Agnew PS. 2019
A multicentre prospective randomised controlled comparative parallel study of dehydrated human umbilical cord (EpiCord) allograft for the treatment of diabetic foot ulcers. Tettelbach W., Cazzell S., Sigal F., Caporusso JM., Agnew PS., Hanft J., Dove C. 2019
Randomized, Prospective, Blinded-Enrollment, Head-To-Head Venous Leg Ulcer Healing Trial Comparing Living, Bioengineered Skin Graft Substitute (Apligraf) with Living, Cryopreserved, Human Skin Allograft (TheraSkin). Towler MA., Rush EW., Richardson MK., Williams CL. 2018
A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers. Zelen CM., Serena TE., Denoziere G., Fetterolf DE. 2013
Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost. Zelen CM., Serena TE., Gould L., Le L., Carter MJ., Keller J., Li WW. 2016
An aseptically processed, acellular, reticular, allogenic human dermis improves healing in diabetic foot ulcers: A prospective, randomised, controlled, multicentre follow-up trial. Zelen CM., Orgill DP., Serena TE., Galiano RE., Carter MJ., DiDomenico LA., Keller J., Kaufman JP., Li WW. 2018




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The data contained in this project are distributed under the terms of the Creative Commons Attribution-NonCommerical license, which permits the use, dissemination, and reproduction in any medium, provided the original work is properly cited, and that the use is non-commercial and otherwise in compliance with the license. See: https://creativecommons.org/licenses/by-nc/3.0/