Project: Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery
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Project: Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery
Project Summary
Title and Description
Title | Screening for Bacterial Vaginosis in Pregnant Adolescents and Women to Prevent Preterm Delivery | |
Description | A review of the evidence about screening for bacterial vaginosis during pregnancy to prevent preterm delivery. | |
Contributor(s) | The authors gratefully acknowledge the following individuals for their contributions to this project: Tina Fan, MD, MPH, AHRQ Medical Officer; Tracy Wolff, MD, MPH, AHRQ Associate Scientific Director; Quyen Ngo-Metzger, MD, MPH, Professor at Kaiser Permanente School of Medicine; current members of the U.S. Preventive Services Task Force; expert peer reviewers Mark Klebanoff, MD, MPH; John Thorp, MD; Valerie J. King, MD, MPH; and Julie van Schalkwyk, MD; two Federal partner reviewers; and RTI International–University of North Carolina EPC staff: Carol Woodell, BSPH; B. Lynn Whitener, DrPH; Sharon Barrell, MA; and Loraine Monroe. | |
Methodology | We conducted a systematic review to evaluate the benefits and harms of screening and treatment for bacterial vaginosis during pregnancy to prevent preterm delivery and the diagnostic accuracy of tests used to screen for bacterial vaginosis. We searched 3 databases from January 1, 2006, through May 29, 2019, building on the literature included in the prior 2008 evidence review for the USPSTF. Because the previous reviews on this topic for the USPSTF did not include a systematic search for KQ 2 (diagnostic test accuracy), we conducted a separate PubMed search from inception through December 31, 2005, to supplement our main search for this update. Two investigators screened each abstract and full-text article for inclusion; abstracted data; and performed quality ratings, applicability ratings, and evidence grading. Where appropriate, we performed a quantitative synthesis by fitting the bivariate model to generate a summary receiver operating characteristics curve (SROC) and a pooled summary point estimate of sensitivity and specificity. | |
DOI | ||
Funding Source | AHRQ | |
Notes | Evidence tables and study quality ratings can be accessed at this link: https://srdr.s3.amazonaws.com/uploads/02-16-2021/BV+Tables+for+SRDR.docx |
Key Questions
1 | Does screening for bacterial vaginosis in asymptomatic pregnant adolescents and women reduce preterm delivery and related morbidity and mortality? a) Does the effect of screening vary by baseline risk (e.g., low- vs. high-risk) for preterm delivery? b) Does the effect of screening vary by race/ethnicity? c) Does the effect of screening vary by maternal age? d) Does the effect of screening vary by gestational age? e) Does the effect of screening vary by other risks for preterm delivery (e.g., coinfection with STIs, HIV status)? | |
2 | What is the diagnostic accuracy of tests used to screen for bacterial vaginosis? a) Does diagnostic accuracy vary based on whether an individual is pregnant? | |
3 | What are the harms of screening for bacterial vaginosis in asymptomatic pregnant adolescents and women? | |
4 | Does treatment of bacterial vaginosis during pregnancy reduce preterm delivery and related morbidity and mortality? a) Does the effect of treatment vary by baseline risk (e.g., low- vs. high-risk) for preterm delivery? b) Does the effect of treatment vary by race/ethnicity? c) Does the effect of treatment vary by maternal age? d) Does the effect of treatment vary by gestational age? e) Does the effect of treatment vary by other risks for preterm delivery (e.g., coinfection with STIs, HIV status)? | |
5 | What are the harms of treatment of bacterial vaginosis in pregnant adolescents and women? a) What are harms to pregnant adolescents and women? b) What are harms to the fetus or newborn? |
Associated Extraction Forms
Title | Created by | Key Questions Addressed | Form Notes |
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Study Data for this published project can be accessed from the SRDR Published Projects page, under the link in the Study Notes section of this project | Robyn Fortman | 1, 2, 3, 4, 5 |
Associated Studies (each link opens a new tab)
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The data contained in this project are distributed under the terms of the Creative Commons Attribution-NonCommerical license, which permits the use, dissemination, and reproduction in any medium, provided the original work is properly cited, and that the use is non-commercial and otherwise in compliance with the license. See: https://creativecommons.org/licenses/by-nc/3.0/ |