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Project: The diagnostic accuracy of digital PCR, ARMS and NGS for detecting KRAS mutation in cell-free DNA of patients with colorectal cancer: a systematic review and meta-analysis

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KRAS mutation detection in cfDNA Peng Ye 1


Associated Studies (each link opens a new tab)

Title Author Year
Detection of RAS/BRAF mutations in the ctDNA of mCRC patients by NGS technique WANG Lei, WANG Mei*, ZHAO Chengshuai, WANG Wei, LI Yongmei 2017
Circulating Tumor Cells and Circulating Tumor DNA Detection in Potentially Resectable Metastatic Colorectal Cancer: A Prospective Ancillary Study to the Unicancer Prodige-14 Trial. Bidard FC., Kiavue N., Ychou M., Cabel L., Stern MH., Madic J., Saliou A., Rampanou A., Decraene C., Bouché O., Rivoire M., Ghiringhelli F., Francois E., Guimbaud R., Mineur L., Khemissa-Akouz F., Mazard T., Moussata D., Proudhon C., Pierga JY., Stanbury T., Thézenas S., Mariani P. 2019
KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer. Sclafani F., Chau I., Cunningham D., Hahne JC., Vlachogiannis G., Eltahir Z., Lampis A., Braconi C., Kalaitzaki E., De Castro DG., Wotherspoon A., Capdevila J., Glimelius B., Tarazona N., Begum R., Lote H., Hulkki Wilson S., Mentrasti G., Brown G., Tait D., Oates J., Valeri N. 2018
Liquid biopsy-based tumor profiling for metastatic colorectal cancer patients with ultra-deep targeted sequencing. Kang JK., Heo S., Kim HP., Song SH., Yun H., Han SW., Kang GH., Bang D., Kim TY. 2020
Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival. Kato S., Schwaederlé MC., Fanta PT., Okamura R., Leichman L., Lippman SM., Lanman RB., Raymond VM., Talasaz A., Kurzrock R. 2019
Correlation of genomic alterations between tumor tissue and circulating tumor DNA by next-generation sequencing. Chang YS., Fang HY., Hung YC., Ke TW., Chang CM., Liu TY., Chen YC., Chao DS., Huang HY., Chang JG. 2018
Cross-platform comparison for the detection of RAS mutations in cfDNA (ddPCR Biorad detection assay, BEAMing assay, and NGS strategy). Garcia J., Forestier J., Dusserre E., Wozny AS., Geiguer F., Merle P., Tissot C., Ferraro-Peyret C., Jones FS., Edelstein DL., Cheynet V., Bardel C., Vilchez G., Xu Z., Bringuier PP., Barritault M., Brengle-Pesce K., Guillet M., Chauvenet M., Manship B., Brevet M., Rodriguez-Lafrasse C., Hervieu V., Couraud S., Walter T., Payen L. 2018
Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancer. Kidess-Sigal E., Liu HE., Triboulet MM., Che J., Ramani VC., Visser BC., Poultsides GA., Longacre TA., Marziali A., Vysotskaia V., Wiggin M., Heirich K., Hanft V., Keilholz U., Tinhofer I., Norton JA., Lee M., Sollier-Christen E., Jeffrey SS. 2016
Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients. Kim ST., Lee WS., Lanman RB., Mortimer S., Zill OA., Kim KM., Jang KT., Kim SH., Park SH., Park JO., Park YS., Lim HY., Eltoukhy H., Kang WK., Lee WY., Kim HC., Park K., Lee J., Talasaz A. 2015
Performance of four platforms for KRAS mutation detection in plasma cell-free DNA: ddPCR, Idylla, COBAS z480 and BEAMing. Vessies DCL., Greuter MJE., van Rooijen KL., Linders TC., Lanfermeijer M., Ramkisoensing KL., Meijer GA., Koopman M., Coupé VMH., Vink GR., Fijneman RJA., van den Broek D. 2020
Circulating Tumor DNA Is Capable of Monitoring the Therapeutic Response and Resistance in Advanced Colorectal Cancer Patients Undergoing Combined Target and Chemotherapy. Cao H., Liu X., Chen Y., Yang P., Huang T., Song L., Xu R. 2020
Guardant360 Circulating Tumor DNA Assay Is Concordant with FoundationOne Next-Generation Sequencing in Detecting Actionable Driver Mutations in Anti-EGFR Naive Metastatic Colorectal Cancer. Gupta R., Othman T., Chen C., Sandhu J., Ouyang C., Fakih M. 2020
Enrichment technique to allow early detection and monitor emergence of KRAS mutation in response to treatment. Kitagawa Y., Okumura K., Watanabe T., Tsukamoto K., Kitano S., Nankinzan R., Suzuki T., Hara T., Soda H., Denda T., Yamaguchi T., Nagase H. 2019
Microarray Approach Combined with ddPCR: An Useful Pipeline for the Detection and Quantification of Circulating Tumour dna Mutations. Galbiati S., Damin F., Ferraro L., Soriani N., Burgio V., Ronzoni M., Gianni L., Ferrari M., Chiari M. 2019
Genomic Profiling of Blood-Derived Circulating Tumor DNA from Patients with Colorectal Cancer: Implications for Response and Resistance to Targeted Therapeutics. Choi IS., Kato S., Fanta PT., Leichman L., Okamura R., Raymond VM., Lanman RB., Lippman SM., Kurzrock R. 2019
Detection of mutations in circulating cell-free DNA in relation to disease stage in colorectal cancer. Liebs S., Keilholz U., Kehler I., Schweiger C., Haybäck J., Nonnenmacher A. 2019
Clinical relevance of circulating tumor DNA assessed through deep sequencing in patients with metastatic colorectal cancer. Osumi H., Shinozaki E., Takeda Y., Wakatsuki T., Ichimura T., Saiura A., Yamaguchi K., Takahashi S., Noda T., Zembutsu H. 2019
Evaluation of three advanced methodologies, COLD-PCR, microarray and ddPCR, for identifying the mutational status by liquid biopsies in metastatic colorectal cancer patients. Galbiati S., Damin F., Burgio V., Brisci A., Soriani N., Belcastro B., Di Resta C., Gianni L., Chiari M., Ronzoni M., Ferrari M. 2019
Monitoring circulating tumor DNA revealed dynamic changes in Takayama Y., Suzuki K., Muto Y., Ichida K., Fukui T., Kakizawa N., Ishikawa H., Watanabe F., Hasegawa F., Saito M., Tsujinaka S., Futsuhara K., Miyakura Y., Noda H., Konishi F., Rikiyama T. 2018
RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients. Yao J., Zang W., Ge Y., Weygant N., Yu P., Li L., Rao G., Jiang Z., Yan R., He L., Yu Y., Jin M., Cheng G., An G. 2018
Monitoring colorectal cancer following surgery using plasma circulating tumor DNA. Sun X., Huang T., Cheng F., Huang K., Liu M., He W., Li M., Zhang X., Xu M., Chen S., Xia L. 2018
RAS testing of liquid biopsy correlates with the outcome of metastatic colorectal cancer patients treated with first-line FOLFIRI plus cetuximab in the CAPRI-GOIM trial. Normanno N., Esposito Abate R., Lambiase M., Forgione L., Cardone C., Iannaccone A., Sacco A., Rachiglio AM., Martinelli E., Rizzi D., Pisconti S., Biglietto M., Bordonaro R., Troiani T., Latiano TP., Giuliani F., Leo S., Rinaldi A., Maiello E., Ciardiello F. 2018
Prospective multicenter real-world RAS mutation comparison between OncoBEAM-based liquid biopsy and tissue analysis in metastatic colorectal cancer. García-Foncillas J., Tabernero J., Élez E., Aranda E., Benavides M., Camps C., Jantus-Lewintre E., López R., Muinelo-Romay L., Montagut C., Antón A., López G., Díaz-Rubio E., Rojo F., Vivancos A. 2018
Somatic mutation detection using various targeted detection assays in paired samples of circulating tumor DNA, primary tumor and metastases from patients undergoing resection of colorectal liver metastases. Beije N., Helmijr JC., Weerts MJA., Beaufort CM., Wiggin M., Marziali A., Verhoef C., Sleijfer S., Jansen MPHM., Martens JWM. 2016
Comparison of the quantification of KRAS mutations by digital PCR and E-ice-COLD-PCR in circulating-cell-free DNA from metastatic colorectal cancer patients. Sefrioui D., Mauger F., Leclere L., Beaussire L., Di Fiore F., Deleuze JF., Sarafan-Vasseur N., Tost J. 2017
Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer. Grasselli J., Elez E., Caratù G., Matito J., Santos C., Macarulla T., Vidal J., Garcia M., Viéitez JM., Paéz D., Falcó E., Lopez Lopez C., Aranda E., Jones F., Sikri V., Nuciforo P., Fasani R., Tabernero J., Montagut C., Azuara D., Dienstmann R., Salazar R., Vivancos A. 2017
Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing. Schmiegel W., Scott RJ., Dooley S., Lewis W., Meldrum CJ., Pockney P., Draganic B., Smith S., Hewitt C., Philimore H., Lucas A., Shi E., Namdarian K., Chan T., Acosta D., Ping-Chang S., Tannapfel A., Reinacher-Schick A., Uhl W., Teschendorf C., Wolters H., Stern J., Viebahn R., Friess H., Janssen KP., Nitsche U., Slotta-Huspenina J., Pohl M., Vangala D., Baraniskin A., Dockhorn-Dworniczak B., Hegewisch-Becker S., Ronga P., Edelstein DL., Jones FS., Hahn S., Fox SB. 2017
Plasma ctDNA RAS mutation analysis for the diagnosis and treatment monitoring of metastatic colorectal cancer patients. Vidal J., Muinelo L., Dalmases A., Jones F., Edelstein D., Iglesias M., Orrillo M., Abalo A., Rodríguez C., Brozos E., Vidal Y., Candamio S., Vázquez F., Ruiz J., Guix M., Visa L., Sikri V., Albanell J., Bellosillo B., López R., Montagut C. 2017
Carrier molecules and extraction of circulating tumor DNA for next generation sequencing in colorectal cancer. Beránek M., Sirák I., Vošmik M., Petera J., Drastíková M., Palička V. -- Not Found --
Limits and potential of targeted sequencing analysis of liquid biopsy in patients with lung and colon carcinoma. Rachiglio AM., Esposito Abate R., Sacco A., Pasquale R., Fenizia F., Lambiase M., Morabito A., Montanino A., Rocco G., Romano C., Nappi A., Iaffaioli RV., Tatangelo F., Botti G., Ciardiello F., Maiello MR., De Luca A., Normanno N. 2016
Utility of KRAS mutation detection using circulating cell-free DNA from patients with colorectal cancer. Yamada T., Iwai T., Takahashi G., Kan H., Koizumi M., Matsuda A., Shinji S., Yamagishi A., Yokoyama Y., Tatsuguchi A., Kawagoe T., Kitano S., Nakayama M., Matsumoto S., Uchida E. 2016
Circulating free DNA as biomarker and source for mutation detection in metastatic colorectal cancer. Spindler KL., Pallisgaard N., Andersen RF., Brandslund I., Jakobsen A. 2015
Multiplex picodroplet digital PCR to detect KRAS mutations in circulating DNA from the plasma of colorectal cancer patients. Taly V., Pekin D., Benhaim L., Kotsopoulos SK., Le Corre D., Li X., Atochin I., Link DR., Griffiths AD., Pallier K., Blons H., Bouché O., Landi B., Hutchison JB., Laurent-Puig P. 2013




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