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Study Title and Description

LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine.



Key Questions Addressed
2 KQ2a. What is the comparative effectiveness of nonopioid pharmacologic therapy (e.g. acetaminophen, NSAIDs, triptans, ergots alkaloids, combination analgesics, muscle relaxants, anti-nausea medications, and cannabis) versus: 1) other nonopioid pharmacologic treatments, such as those in a different medication class; or 2) nonpharmacologic therapy for outcomes related to pain, function, pain relief satisfaction, and quality of life after followup at the following intervals: < 1 day; 1 day to <1 week; 1 week to <2 weeks; 2 weeks to 4 weeks? KQ2b. How does effectiveness of nonopioid pharmacologic therapy vary depending on: (1) patient demographics (e.g. age, race, ethnicity, gender); (2) patient medical comorbidities; (3) the type of nonopioid medication; (4) dose of medication; (5) duration of treatment? KQ2c. What are the harms of nonopioid pharmacologic therapy versus other nonopioid pharmacologic therapy, or nonpharmacologic therapy with respect to: (1) misuse, (2) overdose; (3) MOH, (4) other harms including gastrointestinal-related harms, cardiovascular-related harms, kidney-related harms, falls, fractures, motor vehicle accidents, endocrinological harms, infections, cognitive harms, and psychological harms (e.g. depression)? KQ2d. How do harms vary depending on: (1) patient demographics (e.g. age, gender); (2) patient medical comorbidities; (3) the type of nonopioid medication; (4) dose of medication; (5) the duration of therapy?
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Primary Publication Information
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TitleData
Title LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine.
Author Sang CN., Ramadan NM., Wallihan RG., Chappell AS., Freitag FG., Smith TR., Silberstein SD., Johnson KW., Phebus LA., Bleakman D., Ornstein PL., Arnold B., Tepper SJ., Vandenhende F.
Country Massachusetts General Hospital, Boston, USA.
Year 2004
Numbers Pubmed ID: 15196302

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Question 2
Design Details
Question... Follow Up Answer Follow-up Answer




Results & Comparisons

No Results found.