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Study Title and Description

A 24-week, parallel-group, open-label, randomized clinical trial comparing the early antiviral efficacy of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive chronic hepatitis B virus infection in adult Chinese patients.



Key Questions Addressed
4 Key Question 4. How effective is antiviral treatment in improving intermediate outcomes among nonpregnant adolescents and adults with chronic HBV infection, including virologic or histologic improvement, clearance of hepatitis B e-antigen (HBeAg) (as indicated by loss of HBeAg or acquisition of the antibody to HBeAg [anti-HBe]), or clearance of hepatitis B surface antigen (HBsAg) (as indicated by loss of HBsAg or acquisition of hepatitis B surface antibody [anti-HBs])?
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5 Key Question 5. How effective is antiviral treatment in improving health outcomes among nonpregnant adolescents and adults with chronic HBV infection?
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6 Key Question 6. What are the harms associated with antiviral treatment in nonpregnant adolescents and adults with chronic HBV infection?
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Primary Publication Information
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TitleData
Title A 24-week, parallel-group, open-label, randomized clinical trial comparing the early antiviral efficacy of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive chronic hepatitis B virus infection in adult Chinese patients.
Author Zheng MH., Shi KQ., Dai ZJ., Ye C., Chen YP.
Country Department of Infection and Liver Diseases, Liver Research Center, First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China. blueman1320@163.com
Year 2010
Numbers Pubmed ID: 20435234

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Key Questions 1-7


Results & Comparisons

No Results found.