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Study Title and Description

Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial.



Key Questions Addressed
1 Key Question 1. For patients with an acute respiratory tract infection and no clear indication for antibiotic treatment, what is the comparative effectiveness of particular strategies in improving the appropriate prescription or use of antibiotics compared with other strategies or standard care? a) Does the comparative effectiveness of strategies differ according to how appropriateness is defined? b) Does the comparative effectiveness of strategies differ according to the intended target of the strategy (i.e., clinicians, patients, and both)? c) Does the comparative effectiveness of strategies differ according to patient characteristics, such as type of respiratory tract infection, signs and symptoms (nature and duration), when counting began for duration of symptoms, previous medical history (e.g., frailty, comorbidity), prior respiratory tract infections, prior use of antibiotics, age, ethnicity, socioeconomic status, and educational level attained? d) Does the comparative effectiveness of strategies differ according to clinician characteristics, such as specialty, number of years in practice, type of clinic organization, geographic region, and population served? e) Does the comparative effectiveness differ according to the diagnostic method or definition used, the clinician’s perception of the patient’s illness severity, or the clinician’s diagnostic certainty? f) Does the comparative effectiveness differ according to various background contextual factors, such as the time of year, known patterns of disease activity (e.g., an influenza epidemic, a pertussis outbreak), system level characteristics, or whether the intervention was locally tailored?
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3 Key Question 3. For patients with an acute respiratory tract infection and no clear indication for antibiotic treatment, what is the comparative effect of particular strategies on medical complications (including mortality, hospitalization and adverse effects of receiving or not receiving antibiotics) compared with other strategies or standard care? a) Does the comparative effect of strategies differ according to the intended target of the strategy (i.e., clinicians, patients, and both)? b) Does the comparative effect of strategies differ according to patient characteristics, such as type of respiratory tract infection, signs and symptoms (nature and duration), when counting began for duration of symptoms, previous medical history (e.g., frailty, comorbidity), prior respiratory tract infections, prior use of antibiotics, age, ethnicity, socioeconomic status, and educational level attained? c) Does the comparative effect of strategies differ according to clinician characteristics, such as specialty, number of years in practice, type of clinic organization, geographic region, and population served? d) Does the comparative effectiveness differ according to the diagnostic method or definition used, the clinician’s perception of the patient’s illness severity, or the clinician’s diagnostic certainty? e) Does the comparative effect differ according to various background contextual factors, such as the time of year, known patterns of disease activity (e.g., an influenza epidemic, a pertussis outbreak), whether the intervention was locally tailored or system-level characteristics?
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Primary Publication Information
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TitleData
Title Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial.
Author Schuetz P., Christ-Crain M., Thomann R., Falconnier C., Wolbers M., Widmer I., Neidert S., Fricker T., Blum C., Schild U., Regez K., Schoenenberger R., Henzen C., Bregenzer T., Hoess C., Krause M., Bucher HC., Zimmerli W., Mueller B.
Country Department of Internal Medicine, Kantonsspital Aarau, Tellstrasse, CH-5001 Aarau, Switzerland.
Year 2009
Numbers Pubmed ID: 19738090

Secondary Publication Information
There are currently no secondary publications defined for this study.


Extraction Form: Interventions to Reduce Antibiotic Prescribing for Uncomplicated Acute Respiratory Tract Infections Extraction Form


Results & Comparisons

No Results found.